<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32837

Description Isoform 2 of Transcription elongation factor A protein 1
SequenceMEDEVVRFAKKMDKMVQKKNAAGALDLLKELKNIPMTLELLQSTRIGMSVNAIRKQSTDEEVTSLAKSLIKSWKKLLDGPSTEKDLDEKKKEPAITSQNSPEAREESTSSGNVSNRKDETNARDTYVSSFPRAPSTSDSVRLKCREMLAAALRTGDDYIAIGADEEELGSQIEEAIYQEIRNTDMKYKNRVRSRISNLKDAKNPNLRKNVLCGNIPPDLFARMTAEEMASDELKEMRKNLTKEAIREHQMAKTGGTQTDLFTCGKCKKKNCTYTQVQTRSADEPMTTFVVCNECGNRWKFC
Length280
PositionUnknown
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.04
Grand average of hydropathy-0.806
Instability index44.02
Isoelectric point8.65
Molecular weight33969.30
Publications
PubMed=1708494
PubMed=1378807
PubMed=8112616
PubMed=14702039
PubMed=16421571
PubMed=15489334
PubMed=10029085
PubMed=17081983
PubMed=19367720
PubMed=18669648
PubMed=19413330
PubMed=20068231
PubMed=21269460
PubMed=21127351
PubMed=21406692
PubMed=22814378
PubMed=23186163
PubMed=24275569
PubMed=7626141

Function

Annotated function Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. 
GO - Cellular Component
nucleolus	GO:0005730	IDA:HPA
nucleoplasm	GO:0005654	IDA:HPA
transcription factor TFIID complex	GO:0005669	IDA:UniProtKB

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
positive regulation of exoribonuclease activity	GO:1901919	IEA:Ensembl
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central
transcription by RNA polymerase II	GO:0006366	TAS:Reactome
transcription elongation from RNA polymerase II promoter	GO:0006368	TAS:Reactome
transcription-coupled nucleotide-excision repair	GO:0006283	TAS:Reactome









Interaction





Binary Interactions
[P23193<-->Q92917: GPKOW]	NbExp=3	EBI-2608271,EBI-746309
[P23193<-->Q8WVC0: LEO1]	NbExp=4	EBI-2608271,EBI-932432
[P23193<-->Q8N7H5: PAF1]	NbExp=4	EBI-2608271,EBI-2607770
[P23193<-->P24928: POLR2A]	NbExp=5	EBI-2608271,EBI-295301












Repeat regions





Repeats

>MDP32837
No repeats found











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32837 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PSTEKDLDEKKKEPAITSQNSPEAREESTSSGNVSNRKDETNARDTYVSSFPR
80
132










Molecular Recognition Features






MoRF SequenceStartStop




1) LIKSWKKLL
69
77