<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32834
| Description |
F-box-like/WD repeat-containing protein TBL1X |
| Sequence | MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSKPMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK |
| Length | 527 |
| Position | Tail |
| Organism | Mus musculus (Mouse) |
| Kingdom | Metazoa |
| Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae>
Murinae> Mus> Mus.
|
| Aromaticity | 0.07 |
| Grand average of hydropathy | -0.276 |
| Instability index | 38.46 |
| Isoelectric point | 5.40 |
| Molecular weight | 56801.64 |
| Publications | PubMed=16141072
PubMed=15489334
PubMed=10330347
PubMed=21183079
PubMed=26070566
PubMed=28348241
|
Function
| Annotated function |
F-box-like protein involved in the recruitment of the
ubiquitin/19S proteasome complex to nuclear receptor-regulated
transcription units. Plays an essential role in transcription
activation mediated by nuclear receptors. Probably acts as integral
component of corepressor complexes that mediates the recruitment of the
19S proteasome complex, leading to the subsequent proteasomal
degradation of transcription repressor complexes, thereby allowing
cofactor exchange (By similarity).
ECO:0000250 UniProtKB:O60907
|
| GO - Cellular Component | histone deacetylase complex GO:0000118 ISO:MGI
mitotic spindle GO:0072686 ISO:MGI
nucleoplasm GO:0005654 TAS:Reactome
nucleus GO:0005634 ISO:MGI
transcription regulator complex GO:0005667 IDA:MGI
transcription repressor complex GO:0017053 ISO:MGI
|
| GO - Biological Function | beta-catenin binding GO:0008013 ISO:MGI
chromatin binding GO:0003682 IDA:MGI
DNA binding GO:0003677 IDA:MGI
histone binding GO:0042393 ISO:MGI
identical protein binding GO:0042802 ISO:MGI
protein C-terminus binding GO:0008022 ISO:MGI
protein domain specific binding GO:0019904 ISO:MGI
transcription corepressor activity GO:0003714 IMP:MGI
transcription factor binding GO:0008134 ISO:MGI
transcription regulatory region sequence-specific DNA binding GO:0000976 IDA:BHF-UCL
|
| GO - Biological Process | F:transcription corepressor activity GO:0003714 IMMGI
fat cell differentiation GO:0045444 IMMGI
histone deacetylation GO:0016575 IBA:GO_Central
negative regulation of transcription by RNA polymerase II GO:0000122 ISO:MGI
negative regulation of transcription, DNA-templated GO:0045892 IMMGI
positive regulation of canonical Wnt signaling pathway GO:0090263 ISO:MGI
positive regulation of transcription by RNA polymerase II GO:0045944 IMBHF-UCL
positive regulation of transcription, DNA-templated GO:0045893 ISO:MGI
proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IMMGI
protein stabilization GO:0050821 IDA:UniProtKB
proteolysis GO:0006508 ISO:MGI
regulation of transcription by RNA polymerase II GO:0006357 IGI:MGI
response to estrogen GO:0043627 IMMGI
response to steroid hormone GO:0048545 IMMGI
sensory perception of sound GO:0007605 ISO:MGI
|
Interaction
| Binary Interactions | [Q9QXE7<-->P51608: MECP2] Xeno NbExp=3,
|
Repeat regions
| Repeats |
>MDP32834
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
8| 359.54| 40| 40| 335| 374| 1
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171- 211 (45.94/24.01) PPSKatVLRGHESE...........VFICAWNPVS.........dlL.ASGS.GDSTAR...IWNL...
235- 269 (43.02/22.02) VP....S....NKD...........VTSLDWNSDG.........tlL.ATGS.YDGFAR...I.WTEDG
270- 300 (37.96/18.59) NLAS..TLGQHKGP...........IFALKWNKKG..........nY...............ILSAGVD
301- 352 (48.96/26.06) KTTI..IWDAHTGEakqqfpfhsapALDVDWQNNT..........tF.ASCS.TDMCIH...VCRLGCD
353- 394 (62.60/35.32) RPVK..TFQGHTNE...........VNAIKWDPSG.........mlL.ASCS.DDMTLK...IWSMKQD
395- 447 (42.63/21.76) ACVH..DLQAHSKE...........IYTIKWSPTGpatsnpnsnimL.ASAS.FDSTVRlwdVERGVC.
448- 487 (47.81/25.28) ..IH..TLTKHQEP...........VYSVAFSPDG..........kYlASGS.FDKCVH...IWNTQSG
488- 522 (30.62/13.60) SLVH..SYRG.TGG...........IFEVCWNARG........dkvG.ASASdGSVCV...........
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|
