<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32833

Description Isoform 2 of F-box-like/WD repeat-containing protein TBL1X
SequenceMTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Length526
PositionTail
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.07
Grand average of hydropathy-0.334
Instability index40.37
Isoelectric point6.08
Molecular weight62494.98
Publications
PubMed=10330347
PubMed=14702039
PubMed=15772651
PubMed=15489334
PubMed=10809664
PubMed=10944117
PubMed=11389839
PubMed=11931768
PubMed=12628926
PubMed=14980219
PubMed=24943844
PubMed=27603907
PubMed=30591955
PubMed=21240272

Function

Annotated function F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). 
ECO:0000269	PubMed:14980219
ECO:0000269	PubMed:21240272
GO - Cellular Component
histone deacetylase complex	GO:0000118	IDA:UniProtKB
mitotic spindle	GO:0072686	IDA:UniProtKB
nucleoplasm	GO:0005654	TAS:Reactome
nucleus	GO:0005634	IDA:UniProtKB
transcription repressor complex	GO:0017053	IDA:UniProtKB
GO - Biological Function
beta-catenin binding	GO:0008013	IPI:UniProtKB
histone binding	GO:0042393	IDA:UniProtKB
identical protein binding	GO:0042802	IPI:IntAct
protein C-terminus binding	GO:0008022	IPI:UniProtKB
protein domain specific binding	GO:0019904	IPI:UniProtKB
transcription corepressor activity	GO:0003714	IDA:UniProtKB
transcription factor binding	GO:0008134	IPI:UniProtKB
transcription regulatory region sequence-specific DNA binding	GO:0000976	IDA:UniProtKB
GO - Biological Process
histone deacetylation	GO:0016575	IBA:GO_Central
intracellular receptor signaling pathway	GO:0030522	TAS:Reactome
negative regulation of transcription by RNA polymerase II	GO:0000122	IDA:UniProtKB
positive regulation of canonical Wnt signaling pathway	GO:0090263	IMUniProtKB
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:UniProtKB
positive regulation of transcription, DNA-templated	GO:0045893	IDA:UniProtKB
proteasome-mediated ubiquitin-dependent protein catabolic process	GO:0043161	ISS:UniProtKB
protein stabilization	GO:0050821	ISS:UniProtKB
proteolysis	GO:0006508	IMUniProtKB
regulation of lipid metabolic process	GO:0019216	TAS:Reactome
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
sensory perception of sound	GO:0007605	IMUniProtKB
transcription initiation from RNA polymerase II promoter	GO:0006367	TAS:Reactome

Interaction

Binary Interactions
[O60907<-->P36405: ARL3]	NbExp=3	EBI-3505105,EBI-712710
[O60907<-->Q9BSI4: TINF2]	NbExp=2	EBI-3505105,EBI-717399
[O60907-2<-->P25685: DNAJB1]	NbExp=3	EBI-15904933,EBI-357034
[O60907-2<-->Q13227: GPS2]	NbExp=6	EBI-15904933,EBI-713355
[O60907-2<-->O14901: KLF11]	NbExp=3	EBI-15904933,EBI-948266
[O60907-2<-->A0A024RBS3: NCOR2]	NbExp=7	EBI-15904933,EBI-15904969
[O60907-2<-->O60907-2: TBL1X]	NbExp=2	EBI-15904933,EBI-15904933

Repeat regions

Repeats

>MDP32833
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     374.37|      40|      40|     385|     424|       1
---------------------------------------------------------------------------
  228-  257 (34.19/18.98)	..............LRGHESE...........VFICAWNPVS.........dlL.ASGS.GDSTAR
  276-  313 (44.02/26.89)	HCirEGGHDVP..S....NKD...........VTSLDWNTNG.........tlL.ATGS.YDGFAR
  314-  343 (32.31/17.47)	I...WTEDGNLASTLGQHKGP...........IFALKWNRKG..........nY............
  344-  395 (45.89/28.40)	IL..SAGVDKTTIIWDAHTGEakqqfpfhsapALDVDWQNNT..........tF.ASCS.TDMCIH
  396-  437 (61.67/41.09)	VC..RLGCDRPVKTFQGHTNE...........VNAIKWDPSG.........mlL.ASCS.DDMTLK
  438-  488 (57.81/37.99)	IW..SMKQEVCIHDLQAHNKE...........IYTIKWSPTGpatsnpnsnimL.ASAS.FDSTVR
  492-  530 (51.65/33.04)	IE..RGVC...THTLTKHQEP...........VYSVAFSPDG..........kYlASGS.FDKCVH
  531-  572 (46.83/29.16)	IW..NTQSGNLVHSYRG.TGG...........IFEVCWNARG........dkvG.ASASdGSVCV.
---------------------------------------------------------------------------

Associated diseases

Disease
papillary thyroid cancer	PMID:32532820


Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP32833 with Med16 domain of Kingdom Metazoa



     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKA
174
225










Molecular Recognition Features






MoRF SequenceStartStop




NANANA