<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32795

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMGFLGTNKKFDKNDKERQNQKSTNKSVNPFHRRPMFFEELDISTVQENCNNNNNSSSGEKSSSLGNNATITQPPSVQQPKTPSYLYKSPGMSGLPSIQSNATTPGGTAIDSPRSCAPFSDGPASALPLDANLSSISPHPVRDDGNIYQQDPCSNDPKDTNKNNIDGMSPHPGSVKGAGTGTGSPAVSSANPRTPMNGGQQAKTNDSDTNLQQNVPQNSSDKQETGANGPNSLKRPMLPGDMNENDIGQCKKLLYDFSVVDTVTNIWDIPTPKNRRVIKGLNRPEILRDINDHLLDMSCLKPRDPYEFNDEEFSDFKVEPTEEEVRVECSSDITTRPAEVIAPSAVQLSSANQEDQIVSKEGPKSNAPAGVEDSSIASPKTQKKFTREEELKVSYDDLNYLFSSSSDEESSSEFSTPNAPKVNKSQIGIPQINGNTNLLSGLEDVSKTNNRSNSSTLAELTMIFPTPPSMEINTAPSPCNTLGGIDMTLIDDNAREKLDAYPNSPTSLDSAKDWSYVYKPPIQCKFLTSSKYAPLTDVASLTQYKPRPDCVYKQQEPSLPFQTVKSQSKTQHHPSQQNQQQPHPSHSHHHYQQPNHLYSDKHAHHPSQQNPSLSHHGPSTGLISPSQSNQTNRSSGYLHQFGNSQQQNAMVQPHHTHPGMIPSSHQMNSHYSSQQSPHHHINHHPGQNQNMILNRSGPFSSNSQVHQNPPIMGSGVRMMRPTNNIRGNYPPNHQVPPFIQGHQQAPNMYMNPQFPNSYGPGDRMISPGHPCFSPIMDSNGPQTPFANVNHPPYHHQIPGNNSSHPGHHPPSSIGNISGPLGSLPYDVHSHQAPLISGRPPLPATSPALPTIPDAHCLLINLVLSDSMLNLFKDHNFESCTLCACNGNIKGSDVGIYLPESLVPSDSDEPQYKCTCGFSAVANRHRSYFAGLFYEDEIEITGVVYDPLERLEKKPMIKSEISIKQEQNIDGKEMVTPSTNLYENDQLDASLVNLLRSQCSTLFSSSSLLAKAAIFESLRNKDDSDMVNINSSISIPVLLNSMKVVTKKAFLLRSNALQRSDGCEIAYTALVAPKQVMNGQLSKMALQQLNTPERLNRKASCLHEWSFNNGSTAPNNLDVVRLLRNLTPLLQKSVTKKPQAMWEVTYTVSGPLTWRQFHRLAGRSEDQCEPQPIPSLLVGHDNDWVALSPFALKYWEKLMLEPYSVTRDVAYLVLAPDDTYVLSRVKTYFKELSTTYEMLRLGRHCPIAKVMRDGIMRVGKTVAKNIANEPIDDWFNQIGDGSVASKIKLYARACRYYVAPYLSSQTLDKSLFDNSSPKPDFNSNLNNANRVPTASPHHPPDLSNTNDSKMNDEMNEGASQGSGYTASHLQDTSELDDDPNKQPVIVIYIVEPFTFANMDEEVYRLSCLGLLRCYAQMLNFLPEHLHNSINLQLVSLDSILGVGEDFRGSKRQDQLKALAFSVFNQCRKVLIHHSVSKSLTGFGPAASLDVFLKSKDPNLSITRVYTPPYILAPLKDKQTELGEMFGDGREKSQILYCAYCLTEDQKWLVVTCSNDKGDLLESTLINIEIPNRTRRKKASAKKFGLLKILEFIFSVMTETVQPWRLVIGRLGRVGHGELREWNSLLSKKSLQRYSRLLRDKCRQCSMMTPYEIPSILSACLVSLEADTALRVFPDHFTPDDKYNSSSSTCHLSTPEEASCTHILVFPTSAASSSSQAGFGIGDGGIGGINEDDLLQALGADGGTEDLPVDDELDLFQWTESPTGSPGSRDQGLNHSDDPRQSGFDMNMKSSFGGDLGDDPTNLLQQPLALGYYVSTAQTGPLPKWFWSSCPHLADMNPAFLKSALLIHTPSVQQNNDDFCMNNRNCHPLDSNLTTDVLRYVLEGYNSLSWISLDPATHDRLSCLPIHIQILMQLYHTVQALV
Length1919
PositionMiddle
OrganismTetranychus urticae (Two-spotted spider mite)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Acariformes> Trombidiformes> Prostigmata> Eleutherengona> Raphignathae> Tetranychoidea> Tetranychidae> Tetranychus.
Aromaticity0.07
Grand average of hydropathy-0.586
Instability index50.65
Isoelectric point6.03
Molecular weight212224.27
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32795
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     297.17|      28|      29|     728|     755|       1
---------------------------------------------------------------------------
  135-  172 (27.84/ 9.26)	ISP....HpV.R.DD.........GN.I..YQQ.DPcsndpkdtnknNIDGM...SP..HPG
  585-  613 (26.69/ 8.51)	HSH....H.HyQ.QPnhlysdkhaHH..PS.QQ..................N...PS..L.S
  615-  672 (28.19/ 9.49)	HGP....H.H.T.HP.........GM.IPSSHQ.................MN...SH..YSS
  674-  700 (38.34/16.13)	QSP....H.H.H.IN.........HH..PGQNQ..............NMILNrsgP...FSS
  701-  723 (34.03/13.31)	NSQ....V.H.Q.NP.........P..IMG..S.GV...........RM.MR...PT...NN
  728-  755 (58.13/29.08)	YPP....N.H.Q.VP.........PF.IQGHQQ.AP...........NMYMN...PQ..FPN
  757-  786 (24.23/ 6.90)	YGP....G.D.RmIS.........P....GHPCfSP...........IMDSN..gPQtpFAN
  789-  805 (29.65/10.44)	HPP...yH.H.Q.IP..............GN....................N...SS..HPG
  807-  842 (30.05/10.71)	HPPssigN.I.S.GP.....lgslPYdVHSH.Q.AP...........LISGR...PP..LPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     182.05|      45|      48|     232|     276|       2
---------------------------------------------------------------------------
  191-  225 (38.87/17.40)	...PRTP..MNG.....GQQAK........TNDSDTNLqQNV.PqnsSDKQETG
  232-  276 (83.46/45.52)	LKRPMLPGDMNEN..DIGQCKKL..LYDFSVVDTVTNI.WDI.P...TPKNRRV
  280-  326 (59.72/30.55)	LNRPEILRDINDHllDM.SCLKPrdPYEFN..DEEFSD.FKVeP...TEEEVRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     393.86|     166|     465|     982|    1175|       3
---------------------------------------------------------------------------
  921-  961 (14.37/44.30)	NRHRSYFAGLFYEDEIEITGVVYDPLERLEKKPM..IKSEISI...................................................................................................................................................................................................................................................................................................................................................................
  991- 1175 (247.25/225.10)	NLLRSQCSTLFSSSSLLAKAAIFESLRNKDDSDMvnINSSISIPVLLNSMKVVTKKAFLLRSNALQRSdgceiAYTALVAPKQVMNGQLSKMALQQLNTPERLNRKAScLHEWS...................................................................................................................................................................................................................fnngSTAPNNLDVVRLLRNLTPLLQKSVTKkpqamwEVTYTVSG..PLTWRQFHRlAGRSEDQCEPQPIPSLL
 1563- 1632 (73.99/39.31)	....................................IN..IEIPNRTRRKKASAKKFGLLKILEFIFS.....VMTETVQPWRLVIGRLGRVGHGELREWNSLLSKKS.LQRYS............................................................................................................................................................................................................................................................................................
 1848- 1909 (58.26/24.80)	..................................................................................................................rllrdkcrqcsmmtpyeipsilsaclvsleadtalrvfpdhftpddkynsssstchlstpeeascthilvfptsaassssqagfgigdggiggineddllqalgadggtedlpvddeldlfqwtesptgspgsrdqglnhsddprqsgfdmnmkssfggdlgddptnllqqplalgyyvstaqtgplpkwfwsscphladmnpaflksallihtpSVQQNNDDFCMNNRNCHPLDSNLTTD......VLRYVLEGynSLSWISLDP.ATHDRLSCLPIHIQILM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.80|      17|      18|    1716|    1733|       4
---------------------------------------------------------------------------
 1716- 1733 (28.06/22.68)	FGiGDGGIGGI...NEDDLLQ
 1735- 1754 (25.73/15.14)	LG.ADGGTEDLpvdDELDLFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     177.44|      48|      49|     408|     455|       5
---------------------------------------------------------------------------
  327-  353 (27.96/10.03)	.......................................................ECSSDITTRPAEVIAPSAVQLSSANQE
  364-  434 (50.56/24.64)	SNAPAGVEDSSiaspKTQKK...........ftreeelkvsyddlnylfssssdeESSSEFSTPNAPKVNKSQIGIPQINGN
  435-  477 (62.94/32.64)	TNLLSGLEDVS....KTNNR......SNSST......................laELTMIFPTPPSMEINTA.......PSP
  478-  522 (35.98/15.21)	CNTLGGI.DMT..liDDNARekldayPNSPT......................slDSAKDWSYVYKPPIQ............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.94|      10|     526|      93|     102|       6
---------------------------------------------------------------------------
   72-   81 (18.81/ 8.88)	QPPSVQQPKT
   93-  102 (18.14/ 8.26)	GLPSIQSNAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.28|      21|      23|     537|     559|       8
---------------------------------------------------------------------------
  537-  557 (38.74/22.94)	VASLTQYKPRPDCVYKQQ.EPS
  563-  584 (34.54/13.48)	VKSQSKTQHHPSQQNQQQpHPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32795 with Med13 domain of Kingdom Metazoa
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