<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32787

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMALVETNSFQNRPMSMPTMSLSRLVDFTVQRTYHELLILTDLLPQKSDIERKIEIISFANRTRQLFIRLLALVKWAGSASKVEKCSTIVAFLNKQAMFFIETADSLAKMARENLVQARLPALQLPAAVEVLTLGSYTRLPTCIRDRIVPPDSITPAEKKATLQRLNQIIQQRLVISNLSPQMKNFKIDHGRVIFHVNHEFEMALTLMGDNPNLPWRVLSIDFLVEDKETGGGKDLVHPIQVRCILDIIQSRLNDNSKSLLDPYIVLHTFCLSLQLEVLHAQATRLSRERLGELVKVEEYFLGKKLCISYWRNQDDKSEKSDKSESKSPCKIIIEIDNQDQSKLLQVTHLPELDADTTLSNEPFKFDHLSLEKLLIHTTHERARQYLSSIQEQIKNNQIGKCSLSGCPPVLQISFVHDSLPHERIAVAVDTFSGQLLADIPMFDDPELKDELQTTIKKDPSNWSPLLDKLKILVYRDRFKRAAEYLSVSTHDSLLWHSSVNHPVISDTTTAKLYVQFCRYPKNFMLITFKPNLRNSEKEMDFRYYLLSIEPVPIEFFDDQSSSDDQDIPKLSAKLLSLFEIDVPSSLGSPKAAFEYFNLVNGAGKRKLICDDYNLKRSKICNSFTSEFMHLVNFCDEKLFFGVLSSELLKRRICHQVRDCDKAGYMHYIDITQYPPDSFESASRLRSNLISCTIRLQSRGIYKIWVVSLTFFNSPVLNQTPRDATQKKVVCMVYDFSTGFHSQLVQMINDLHNDWIAISKVYEIFADFIDQMNATNSPPVFEIKSFNYKKLTLGYGPNKGYIVSINWKPFEKRYHLSFAINGLSSSNINPHLIIAAQLQHEFNQHRSIAWLLQTLNSTFSPLLTLQNLTSTPLLGVVNSRPHVPVQTFCIVPQKSNHIRLIYRNTYCLDIILSVDGFVSIRDGAYSLFDKAKVLEELSPIQGLKAFLNKFVDKNAAQMRRLSQTEDDNPPSPMTHIEHVEPYLFQSNHNQTASPMTINSAQDSMMMNAGGPGARGMRQVMTPGSLSHPNTPASPHTSVLNQNAYASSPNPSFALASPPSHGYQTSQSGQIAPSPSIPVSHPEQSPGNIFGVNSPMNPLHAPSPSFLPIASPSAATNIHSPASNFMSTSHDHSVNSPFPGPGGSNISMQSPASVPWPNSPSMARPSPRPGPSPVGGGLGASPQTNVSPHYHNVPGHIAMSSTRFLPQRAWAAANPTLLTYQGFDNMCRPHAPLESPPAHHHNPVYASLSQLERFLGCVFMRKTLQRTLGAGDGFQVITSNPTPGIIQFKNETLQFKITVHPITMQSLQISIIPFPEHENSWLSEELDILKRFFESRVVCAPYKPNPFISYSRLLNVPHRVCKDCIQLMRLELFPDPSLKWTLQWLLTITPAQLDRPIGKPGMSAVFVFKGSTVVFFLQFTRVMHNLPMNVEPQTLVIPFMFEMERNILRVASDKSTGAQTQTYPVINEINTILARYNEYQMQSGEYSIFHAIREIMMSDLAAQPV
Length1503
PositionTail
OrganismTetranychus urticae (Two-spotted spider mite)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Chelicerata> Arachnida> Acari> Acariformes> Trombidiformes> Prostigmata> Eleutherengona> Raphignathae> Tetranychoidea> Tetranychidae> Tetranychus.
Aromaticity0.09
Grand average of hydropathy-0.227
Instability index51.76
Isoelectric point8.32
Molecular weight169514.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32787
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     300.31|      78|      93|     992|    1073|       1
---------------------------------------------------------------------------
  992- 1061 (110.28/56.62)	.....................SPMTINSAQDSMM.MNAGGPgarGMRQVMTPGSL.SHPNTPASPH.TSVLNQNAYASS...PNP...SFALASPPSHGY
 1062- 1154 (111.69/55.12)	QTSQSgQIAPSPsipvshpeqSPGNIFGVNSPMNpLHAPSP...SFLPIASPSAA.TNIHSPASNF.MSTSHDHSVNSP..fPGPggsNISMQSPASVPW
 1155- 1218 (78.34/34.23)	PNSPS.MARPSP.....rpgpSPVG...........................GGLgASPQTNVSPHyHNVPGHIAMSSTrflPQR...AWAAANPTLLTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.87|      51|      93|     330|     381|       2
---------------------------------------------------------------------------
  330-  381 (81.48/53.24)	KIIIEIDNQDQSKLLQVTHL..PEL..DADTTLSNEPFKFDHLsLEKLLIHTTHER
  423-  477 (77.39/46.21)	RIAVAVDTFSGQLLADIPMFddPELkdELQTTIKKDPSNWSPL.LDKLKILVYRDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.75|      14|      28|     132|     148|       5
---------------------------------------------------------------------------
  132-  148 (20.59/17.62)	TLgsyTRLPTCIRDRIV
  161-  174 (24.16/11.61)	TL...QRLNQIIQQRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.47|      29|      30|      39|      67|       7
---------------------------------------------------------------------------
   39-   67 (47.33/30.89)	LTDLLPQKSDIERKIEIISFANRTRQLFI
   72-  100 (49.13/32.34)	LVKWAGSASKVEKCSTIVAFLNKQAMFFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.37|      31|     523|     809|     860|       8
---------------------------------------------------------------------------
  829-  860 (52.66/61.08)	PHLII..AAQLQH.EFNQHRSIAWLLQTLnSTFSP
 1355- 1388 (52.71/21.42)	PHRVCkdCIQLMRlELFPDPSLKWTLQWL.LTITP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.17|      10|     522|     149|     158|      16
---------------------------------------------------------------------------
  149-  158 (19.71/ 8.89)	PPDSITPAEK
  674-  683 (19.46/ 8.69)	PPDSFESASR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32787 with Med14 domain of Kingdom Metazoa
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