<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32782

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAMPVSVSVEVAIENHIQEISYDGQEVFVQPLSMSENLSKLAQKIDFKTDDDNNKASELAEGAKEDDESKEIVPFQQPIWPNSLTEVSVLLDVLNVAKEKRYLVLDPVTPDVSVEPKPLAQLYAKKKSLAGAANILLNGAERLRTCQMEMSRNRNVPDFHLELLRLRQNWRLKKVGTTILGDLSYKTAGSRFWQNGVFEVTKSEESNASPPPSPNNYGVGAPRLESALKVTVPSELEGISYIQVTIQKDQENLCSARLTIPNPQSGVNNSEGYWQQKLEAAQNVLFCKELFAQLAREAVQLQAPIPHMVVSNQITASLFPGIQLIVGLCHSSSQEKKKPDHNHVLEHSLHQLLREVHHNTMHHPMPHPATAMLGVSKRRRLAGPEAFDRHALLEMTKSETLLEQIIKQAQHVVLRLRTMYVIDTLAREIKDPLIVAHWNCLNSPTQSCVKINIVTHGYETVCRTSLIVHVREKTLKAICRDGKVMQMSYEPQELRDLILCQISQHQVTAVQALSKLMGWQILASSNNLGIGPVEPLGNASSVVMASPSGDRVIILRCGPNTSFQVFIQSSPRKDFYPSQLVKDMRWENLGGNSREIRWDKMEGRNFLNRVEMLMASLTSC
Length620
PositionHead
OrganismStrigamia maritima (European centipede) (Geophilus maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Myriapoda> Chilopoda> Pleurostigmophora> Geophilomorpha> Linotaeniidae> Strigamia.
Aromaticity0.05
Grand average of hydropathy-0.297
Instability index47.89
Isoelectric point7.29
Molecular weight69524.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32782
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      16|     328|     342|       1
---------------------------------------------------------------------------
  328-  342 (28.29/16.17)	LCHSSSQEKKKPDHN
  345-  359 (27.15/15.26)	LEHSLHQLLREVHHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.10|      13|      42|     257|     269|       2
---------------------------------------------------------------------------
  257-  269 (23.79/13.16)	RLTIPNPQSGVNN
  300-  312 (23.31/12.76)	QLQAPIPHMVVSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.48|      33|      42|      67|     101|       3
---------------------------------------------------------------------------
   67-  101 (51.86/35.67)	DESKEIVPFQQ.PIWPNSLTEVSVLLdvLNVAKEKR
  111-  144 (49.62/28.31)	DVSVEPKPLAQlYAKKKSLAGAANIL..LNGAERLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      14|      17|     364|     377|       6
---------------------------------------------------------------------------
  364-  377 (26.07/15.42)	PMPHPATAMLGVSK
  384-  397 (24.43/14.05)	PEAFDRHALLEMTK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32782 with Med17 domain of Kingdom Metazoa
Unable to open file!