<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32776

Description Uncharacterized protein
SequenceMASSEMSVGDRKIEDGKSEIILERLRNKASHMKPWTETIKAYRLALLDKRYTVDNADRLQMQKCLDTLQKSIKVTSLQAMVERLESITRQLRKRNFDDCSLKFTAGPNGTDCFISSDMFYVEVLLEMNGSVKDVKIAHHGDPVSCSELTQVLRAGDFTEFTSHLEGLTSIYQLNADKKQKSKAYLALQALETDLSMLAQLQSSINEPSNLVHKSPVGILQLRKGGHPMKLTYFISPYDLLDMETKSSIPLTVDTVVERQLGQYVTVCIESSTSHKLQTQSLMSITRTNDGKSLPSFAAPSNLNSTTLPANFVLKLASPMPIATALVKKIQAVTCIECADMSSSQPLLSLITQLASKGEMDCNNNKGLFVVLPDQHHCYFLNGAADLQGAMVSSIPFTHPTHVPQILVFLRQQMLFNVLISSCIRTGSKQDLETALMFEVTALSWLHVSVSFEHPLEESMATAEFDLSDITNVKCKLCTMGSDASICSDEYASKVVQRCLSIPVTMRAVIRKAQGQQKKANQSNEDIYVTMVTGNSGKFLSNAQNSTHNEGSNNQGGNNNAKFVSDFDVKLCRSGNRTSDSQSISKLDVLNTNVGSSSSSSYNMPSPDIATTPLGMDGQGYNESSPAHGDLFPLNSERASALILSGNHFGPPNSSQPSNLGKSGNSVTVTNTNQRQLVTLVSNAMGGHVKPRKERVKRKAVSEGNSPRSQTGRSPKQKHSEDDLVKDLSQSDVEVGNSSSMTTIPLGVDMELSVRQNIDPGLVKSTLEGMVKYEPMGSRAEINQHLMHRGSTSMHNESNAMDSDFFNSGNQNRSNEAEFNYKSEPMDFENEVYSNQNSTYDDGLMESGDEFNLEQLGINSSVLAAKIEKNKEAKKLKKLKLEIATKLGDKEQSGDGDAKSTPPPVIFDIISSQLKVVEPTKNACAVDLTEKRPNVEIIPIGNTSGSSSASLLTQGGLKIGLKSGESKLKQRDFRRGLVGDRSDKKSKGEGKRERKRKHLESLNSSDDKSGNKLLAVSITPVPLMTGSGVNVDKGMSIVSKSNEPTLPKSITLSVKSISASSSMSTSTAAITSKTVTTSCKKPQLPLSTTVSPTKSVSILKTPQSNKAKQGSIKPLGMVKSGQLGDSKTLSPSANKVTISPLKVHSGKAKSSSSKSLVSGSKPTTVRLKHLNIPSSTTVTPIIKASPTSTATTTLPSPTVTSPPVTFTALTAAASGVSTPTTPTSTAAMKMPALSVTTSVGFTNPTVTSTSATDSSSNGSGNATSGESGGGGNATKLSKSANRSRKGSLSAVIDKLRNSNRQSGSCDGQPAPSERKESKDGGGGSGGGGGEKKEAMKKESSHKDVGGAAKTGDKPKVGSGAEQKLSEKKPEFTVKQSSQGIKLTVTKTRSTESGGSKLSSSLKNSSSKLNASSNKSGTATTGGSSGGSVPKMTPSGGATGSKPGVGPASSKKLSGVSTSSKSPGGAVSAASGSSNSAVKPTVSKTPPLTSAGATFVSSATTKPISSATVKQSGGQKHGSADGKSVTSLSGTKMSERVQKSLSSTGHENSKAGGVLKLEKSSSLPNSMPPPPPPPIATDMGGQSRKSDDANRQRQSPKQSGSDETEAERQFRLLLAQTKMESNSGSTTTLTNSNLITKPTVTNSQPPLSSASGICSTAEKPEGSRTPKQELSDRSPKNNDGRSTPKTSTSGEKLFNFITNITNITSSMSSKTTPVVTMTTAVSEAKTMAAPVKASESGALKSTEVVNKCPGPASPPESASKVPNIFDHLKAVVKRQQNSPSNDDVSSPEDSLIIDYPGTPHHKSPEKKLKNVNVEQVVATGQTKSPTSPMVTTARSPAQPSPGIKSPMVIGTPHSDHSNPSSVARSSPCVIDDDLMDEALMGVGK
Length1882
PositionMiddle
OrganismStrigamia maritima (European centipede) (Geophilus maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Myriapoda> Chilopoda> Pleurostigmophora> Geophilomorpha> Linotaeniidae> Strigamia.
Aromaticity0.03
Grand average of hydropathy-0.527
Instability index47.98
Isoelectric point9.38
Molecular weight198810.49
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32776
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.13|      16|      16|     631|     646|       1
---------------------------------------------------------------------------
  631-  646 (29.15/15.76)	F.PLNSERASALILSGN
  648-  664 (27.98/14.80)	FgPPNSSQPSNLGKSGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     743.99|     146|     151|    1003|    1153|       2
---------------------------------------------------------------------------
  935- 1109 (182.22/69.12)	EIIPIG..NTSG.......SSS....ASLLTQ.........................GGLKIglKSGESK.....lkqrdfrrglvgdrsdkkskgegkrerkrkhleslnSSDDKSGNKllavSITP....VPLM........TGSG........VN..VDKGMSIVSKSNEPTLPKSITLSVKSISASSSMSTSTAAI.T.SKTVTTSCKKPQLPL..STTVS..PT..........KSVSI.LKTPQSNK.....AKQG
 1110- 1226 (155.03/56.34)	SIKPLGmVKSGQLGDSKTLSPS....ANKVTI.........................SPLKV..HSGKAKSSSSK.................................slvS.....GSK.......P....TTV..................................RLKHLNIPSSTT..VTPIIKASPTSTATTTL.P.SPTVTS....PPVTF..TALTA..AA..........SGVST.PTTPTSTA.....A...
 1227- 1350 (127.14/42.64)	.......MKMPALSVTTSVGFT....NPTVT.................................STSATDSSS.......................................................................NGSG.........N..ATSGES.GGGGNATKLSKSANRSRK.....GSLSAVIDKLrN.SNRQSGSCDGQPAPS..ERKES..KDggggsgggggEKKEA.MKKESSHKdvggaAKTG
 1351- 1516 (153.61/53.24)	D.KP....KVGS.GAEQKLSEK....KPEFTVkqssqgikltvtktrstesggsklsSSLKN..SSSKLNASSNK....................................SGTATTGGS....SGGS....VPKM........TPSGgatgskpgVGpaSSKKLSGVSTSSKS..PGG......AVSAASGSSNSAVKP.TvSKT.......PPLTSagATFVSsaTT..........KPISS.ATVKQSGG.....QKHG
 1622- 1740 (125.99/42.19)	.............GSTTTLTNSnlitKPTVT..............................N..SQPPLSSASGI....................................CSTAE...K.......PegsrTPKQelsdrspkNNDG.........R..STPKTS...TSGE.KLFNFIT.NITNI..TSSMS.........SKT.T.....PVVTM..TTAVS..EA..........KTMAApVKASESGA.....LKST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.48|      38|     180|    1563|    1605|       3
---------------------------------------------------------------------------
  573-  609 (43.97/16.84)	...SG.NRTSD.....SQSISKLDVLNTNVG.............SSSSSsynmPSPDIA
 1524- 1574 (58.35/26.28)	TSLSG.TKMSE...RVQKSLSSTGHENSKAGgvlklekssslpnSMPPP....PPPPIA
 1575- 1605 (27.16/16.85)	TDMGGqSRKSDdanRQRQSPKQSGSDETEAE............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     390.41|     128|     152|     232|     383|       4
---------------------------------------------------------------------------
  241-  383 (208.93/142.16)	DMETKSSIPLTVDTVVE......RQ...LGQYVTVCIESSTSHKLQTQSLMSITRTNDGKSLPSFAAPsnLNSTTLPANFVLKlaspmpiatalvkKIQAVTCIEC...ADMS.SS........QPLLSL.ITQLA....SKGEMDCNN..NKGLFVVLPDQHHCYFLNGA
  387-  542 (181.48/89.67)	QGAMVSSIPFTHPTHVPqilvflRQqmlFNVLISSCIRTGSKQDLETALMFEVTALSWLHVSVSFEHP..LEESMATAEFDLS.............DITNVKCKLCtmgSDASiCSdeyaskvvQRCLSIpVTMRAvirkAQGQQKKANqsNEDIYVTMVTGNSGKFLSNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.45|      29|      79|     744|     776|       5
---------------------------------------------------------------------------
  746-  776 (45.32/39.64)	GVDMELSVRQN..IDPGLVKSTLEgmVKYEPMG
  826-  856 (45.14/24.59)	DFENEVYSNQNstYDDGLMESGDE..FNLEQLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     332.63|     109|     118|       5|     119|       6
---------------------------------------------------------------------------
    5-  119 (164.02/119.52)	EM..SVGDRKIEDGKSEIILERLrNKASHMKPWTETIKayRLALLDKRYTVdNADRLQMQKCLDTLQkSIKvTSLQAMVERLESI...TRQLRKRNFDDCSLKFTAGPNGTDCFISS.DMF
  126-  240 (168.61/100.96)	EMngSVKDVKIAHHGDPVSCSEL.TQVLRAGDFTEFTS..HLEGLTSIYQL.NADKKQKSKAYLALQ.ALE.TDLSMLAQLQSSInepSNLVHKSPVGILQLRKGGHPMKLTYFISPyDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.64|      15|      17|    1822|    1838|       7
---------------------------------------------------------------------------
 1824- 1838 (28.19/15.41)	TSPMV..TTARSPAQPS
 1842- 1858 (25.45/ 7.01)	KSPMVigTPHSDHSNPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32776 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KAKSSSSKSLVSGSKPTTVRLKHLNIPSSTTVTPIIKASPTSTATTTLPSPTVTSPPVTFTALTAAASGVSTPTTPTSTAAMKMPALSVTTSVGFTNPTVTSTSATDSSSNGSGNATSGESGGGGNATKLSKSANRSRKGSLSAVIDKLRNSNRQSGSCDGQPAPSERKESKDGGGGSGGGGGEKKEAMKKESSHKDVGGAAKTGDKPKVGSGAEQKLSEKKPEFTVKQSSQGIKLTVTKTRSTESGGSKLSSSLKNSSSKLNASSNKSGTATTGGSSGGSVPKMTPSGGATGSKPGVGPASSKKLSGVSTSSKSPGGAVSAASGSSNSAVKPTVSKTPPLTSAGATFVSSATTKPISSATVKQSGGQKHGSADGKSVTSLSGTKMSERVQKSLSSTGHENSKAGGVLKLEKSSSLPNSMPPPPPPPIATDMGGQSRKSDDANRQRQSPKQSGSDETEAERQFRLLLAQTKMESNSGSTTTLTNSNLITKPTVTNSQPPLSSASGICSTAEKPEGSRTPKQELSDRSPKNNDGRSTPKTSTSGEKLF
2) QRDFRRGLVGDRSDKKSKGEGKRERKRKHLESLNSSD
3) SSMSSKTTPVVTMTTAVSEAKTMAAPVKASESGALKSTEVVNKCPGPASPPESASKVPNIFDHLKAVVKRQQNSPSNDDVSSPEDSLIIDYPGTPHHKSPEKKLKNVNVEQVVATGQTKSPTSPMVTTARSPAQPSPGIKSPMVIGTPHSDHSNPSSVARSSPCVIDDDLMDEALMGVGK
4) VGSSSSSSYNMPSPDIATTPLGMDGQGYNESSPAHGDLFPLNSERASALILSGNHFGPPNSSQPSNLGKSGNSVTVTNTNQRQLVTLVSNAMGGHVKPRKERVKRKAVSEGNSPRSQTGRSPKQKHSEDDLVKDLSQSDVEVGNSSSMTTIPLGVDMELSVRQNIDPG
5) VKSTLEGMVKYEPMGSRAEINQHLMHRGSTSMHNESNAMDSDFFNSGNQNRSNEAEFNYKSEPMDF
6) VSPTKSVSILKTPQSNKAKQGSIKPLGMVKSGQLGDSKTLSPSANKVTISPLKVHS
1146
969
1703
593
762
1089
1692
1005
1882
760
827
1144










Molecular Recognition Features






MoRF SequenceStartStop




1) AERQFRLLLAQTK
2) EKKEAMKKESSHKDV
3) IFDHLKAV
4) KKLKKLKLEIATKL
5) KLSEKKPEFT
1604
1329
1762
873
1362
1616
1343
1769
886
1371