<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32772

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMADQSDQSWRSQGFRQKVIAQIEEAIWQSGSQTPKTSSEMENHVFEKAHSKDEYLGLVARLILHLRELSSKNKQGPPTHPGHGGMPPSGVGVPDPINALQNLARQKGNNPQMGGGMAGPNQMPMMVGMNPQNNAMQGPGMQHMVISGGMAGNMQLQQMQRGMRQPQQQQPNPQQLQHPGKPSTPQMQMQQGQLNEALLHQVPGGAPHARQDNNSNQYLGQSPNPVPISNHMAANPSPVHQPTNTIAMSPAGYAPSPSPQIVPSPLGGGGSQSANRTPGPMSSAPSPNSNLSTPMGAAASPAGRSINDDQVYLDKVKQLSKYIDPLRRMITRYDKDEGKVAEKKREMSKMKNLLDILSDPTKRVPMDTLLKCEQVLEKLDFKNKPSDASIGIPLFPPGHTKEQSICLPLLEAITAHIKSPMLNHTLQRTFGPAMASLHGPPIKCPSPPAYKKRKTDDDANDIPDALQGEIARLDQRFKVSLDPIQHGGSRTVHLICQLDDKNLPCVPPITITVPENYPQQTPQCDTSSEEYDSTPFLQAVQVALSARIMKMPEKFSVTSLLDTWEMSVRQACAPRPLQNCMDECENDNSQDCCPPAPPPCVCPPCPAHDEPCPAHGYGGDEACSVCHEPTCCCVGSSGTCDDDFGISLHDTGCPVIQYRCPCECTCDCSTDPDPYYLREPSEIAIEEEPPAVQQTLQNVWQSMVSLLSPEKGEIKPICPEEKLNVIIDTDCGVDDALAILMALKSPQIQLLAITCVYGNVPVNEVLQNVLRVLRMVDATGVAVYVGAKFPLIEEYIRPECSPHGPDGFGGAAWEFPPAENVVVGPYCAWKALQRLANQMPGQLTVVALGPLTNLALAQKTDSSFSSKLKEVFIAAKGTVKFTAEQNFSNDPEAAFIVLREFACPKTVLPYETCVRAAPSFEWYDTQLASNTYELGQFIRRLTERYVMAHRDVRKSAGFVARDLFTMATALRPSIVRCVKPFYVSCELWGTLTRGQMVMEQRPWVPTEPNAHVILSMDVAAMANFIEEIPVYVGCERPLVNPLMADTDFHGADGLGNVELPRDEKLKPKSCLAAVALVDYVIECPDQLTLVALGPLTNLVIAQRLNQKFSSKLKTLVFMGGNLRGSGNITATAEFNVYVDPEAAQVVLNEFVCPILCVPWDPCFDNPISQETYRMLTSMETKRSNFMRDITAYSVNWAANICKDMGYFPCDLYAMACVLFPEVIRRSEKWFAAVELAGLSTRVIDTDCGVDDALAILLAVVHPGVKVKAITCCFGNTNLANVWGNVFRVLKICNRTDIPVYVGCDRNILGSDIIDAGGFHGDDGFGNIASTIPITGCQHESEHASLALLRLVNENPGQVTLVALGPLTNLALAQRLDPKFSTKLNRLVYMGGNIEGQGNVSTAAEFNFYSDPEAAAVVLNEFQCPMLCIPWETCLKYHLSWDDYNQLMSIVTEKAIFVKNLTKNSIPLLHKRKRAGYHSCDLLAMAIVVDEKVATEIVNCHATVELVGTRTRGQMVTDHRRWSGSKPNIHFVKEVDNDAFLQLFRGMIS
Length1547
PositionTail
OrganismStrigamia maritima (European centipede) (Geophilus maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Myriapoda> Chilopoda> Pleurostigmophora> Geophilomorpha> Linotaeniidae> Strigamia.
Aromaticity0.06
Grand average of hydropathy-0.235
Instability index48.48
Isoelectric point5.67
Molecular weight169577.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32772
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     226.21|      36|      66|    1082|    1117|       1
---------------------------------------------------------------------------
  839-  871 (52.49/31.92)	.PGQLTVVALGPLTNLALAQKTDSSFSS.KLKE.VF.
 1082- 1117 (69.31/44.81)	CPDQLTLVALGPLTNLVIAQRLNQKFSS.KLKTLVFM
 1151- 1181 (42.24/24.07)	CP..ILCVPWDPCFDNPISQETYRMLTSmETKR....
 1354- 1388 (62.16/39.33)	.PGQVTLVALGPLTNLALAQRLDPKFST.KLNRLVYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     625.63|     147|     268|    1026|    1240|       2
---------------------------------------------------------------------------
  780-  992 (182.75/92.62)	.VAVYVGAKFPLIEEYIrPEC.SPHGPDGFGGAawEFPPAENvvVGP.YC.AWKAL...............................................qrlanqmpgqltvvalgpltnlalaqktdssfssklkevfiaAKGTVKFTAEQNFSNDPEAAFIVLREFacpktvlpyetcvraapsfewydtqlasntyelGQ..................................FIRRLTERYVMAHRDVRKSAGFVARDLFTMATALRPSIVRCVKPFYVSCELWGTLTR
 1026- 1240 (233.68/121.40)	EIPVYVGCERPLVNPLM.ADT.DFHGADGLGNV..ELPRDEK..LKPKSCLAAVALVDYVIEcpdqltlvalgpltnlviaqrlnqkfssklktlvfmGGNLR..........................................GSGNITATAEFNVYVDPEAAQVVLNEF.vcpilcvpwdpcfdnpisqetyrmltsmetkrSN..................................FMRDITAYSVNWAANICKDMGYFPCDLYAMACVLFPEVIRRSEKWFAAVELAGLSTR
 1295- 1510 (209.19/107.02)	DIPVYVGCDRNILGSDI.IDAgGFHGDDGFGNIasTIP.ITG..CQHESEHASLALLRLVNEnpgqvtlvalgpltnlalaqrldpkfstklnrlvymGGNIE..........................................GQGNVSTAAEFNFYSDPEAAAVVLNEF...................................qcpmlcipwetclkyhlswddynqlmsivtekaiFVKNLTKNSIPLLHK.RKRAGYHSCDLLAMAIVVDEKVATEIVNCHATVELVGTRTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     202.82|      54|     515|     725|     778|       3
---------------------------------------------------------------------------
  725-  778 (99.16/53.24)	IIDTDCGVDDALAILMALKSPQIQLLAITCVYGNVPVNEVLQNVLRVLRMVDAT
 1241- 1294 (103.66/55.95)	VIDTDCGVDDALAILLAVVHPGVKVKAITCCFGNTNLANVWGNVFRVLKICNRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      74.36|      18|      18|     601|     618|       4
---------------------------------------------------------------------------
  601-  613 (23.46/ 7.36)	........CP...PCPAHDEPCPA
  614-  632 (29.12/11.01)	HGYGGdeaCS...VC..HEPTCCC
  633-  654 (21.77/ 6.27)	VGSSG..tCDddfGISLHDTGCPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.59|      19|      19|     110|     128|       5
---------------------------------------------------------------------------
  110-  128 (40.79/18.70)	PQM.........GGGMAGPNQMPMMVGM
  165-  192 (25.97/ 9.11)	PQQqqpnpqqlqHPGKPSTPQMQMQQGQ
  215-  231 (26.82/ 9.65)	NQY.........LG..QSPNPVPISNHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.14|      25|      27|     249|     275|       6
---------------------------------------------------------------------------
  249-  275 (40.69/23.63)	PAGYAPSPSPQIvPSPLGGGGSqSANR
  279-  303 (46.45/19.82)	PMSSAPSPNSNL.STPMGAAAS.PAGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.20|      17|      22|     560|     579|       7
---------------------------------------------------------------------------
  560-  579 (30.83/19.69)	LDTWEMSVRQAC...APRPlqnC
  580-  599 (32.37/13.89)	MDECENDNSQDCcppAPPP...C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.64|      26|     517|     902|     928|       8
---------------------------------------------------------------------------
  902-  928 (47.75/36.47)	CPKTVLPYETCVRAAPSFEWYDtQLAS
 1422- 1447 (56.89/39.00)	CPMLCIPWETCLKYHLSWDDYN.QLMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.41|      13|      22|     129|     142|      10
---------------------------------------------------------------------------
  129-  142 (24.93/17.86)	NPQNNAMQgPGMQH
  152-  164 (24.48/12.37)	NMQLQQMQ.RGMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.79|      22|      28|     392|     419|      11
---------------------------------------------------------------------------
  397-  419 (34.35/27.18)	GHTKEQSIClPLLEAI.TAHIKSP
  422-  444 (37.44/13.57)	NHTLQRTFG.PAMASLhGPPIKCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.86|      15|      28|     469|     483|      15
---------------------------------------------------------------------------
  469-  483 (25.37/16.22)	IARLDQRFKVSLDPI
  494-  508 (29.49/20.31)	ICQLDDKNLPCVPPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.28|      28|     516|     993|    1020|      16
---------------------------------------------------------------------------
  993- 1020 (53.62/34.06)	GQMVMEQRPWVPTEPNAHVILSMDVAAM
 1511- 1538 (53.67/34.10)	GQMVTDHRRWSGSKPNIHFVKEVDNDAF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32772 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQIEEAIWQSGSQTPKTSSEMENHVFEKAH
2) LRELSSKNKQGPPTHPGHGGMPPSGVGVPDPINALQNLARQKGNNPQMGGGMAGPNQMPMMVGMNPQNNAMQGPGMQHMVISGGMAGNMQLQQMQRGMRQPQQQQPNPQQLQHPGKPSTPQMQMQQGQLNEALLHQVPGGAPHARQDNNSNQYLGQSPNPVPISNHMAANPSPVHQPTNTIAMSPAGYAPSPSPQIVPSPLGGGGSQSANRTPGPMSSAPSPNSNLSTPMGAAASPAGRSINDDQV
20
65
49
310










Molecular Recognition Features






MoRF SequenceStartStop




1) QGFRQKVIAQIEEAIW
12
27