<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32769

Description Uncharacterized protein
SequenceMASSMVPIPLEGHQTPVALQSHCIGGNNSGSISLSVLVDFLLQRTYHELSVLSELLPRKTDMERKIEIVSFASRTRQLFVRLLALVKWANSASKVDKCSAIMQFLDKQSMLFIETADMLARMARETLVHARLPNFHLPCAVEVLTTGTYLRLPTCIRDRIVPADPITPLEKRSTLLRLNQIIQYRLVTSADLPAQMRSIKIEYGQVTFQVEHEFEVSLTVMSDSLTDPWRLIDINVLVEDKETGDGKPLVHPLQVHFIHQLIQSRLLDNPKPLHDLYSVLHSFCLSLQLEVLHSQVMRLRTERLTGYIAVEYSPGVSLTIFYWSNLLNRYELPDIGYKLTLQIHSYDSSKPLQIIHVPRLGSKECQQADHAFKSDQLSIEKLLVHTIYIRTKQRLHELKEEIKPKLGSVEFNIVGSPAVLHIPILQPCLRSEQLLVSIDTHKGIFLAHVPQYEPPMIQEIQQTLNGDKSKLEALIMELRYWIVLRRCEKTLQYLPVITTESLPLVDSGELTVSLSQMSKHKLFIKLCRHSNCYVIVELKEASKNPYEVHLEYHLLVTKLVPLEDEPAADTDAQRSFLSISSLVQFDAFTITHGPFTIVDVDQIDKGYGKRRLPLKMNEPPVKRSKPPAYFLPDLAHIIAMCDERLPFSSFMEELNRRNVCNQGVQVEANGACLCIKLVKMPDCDGVDKNVLENLRHSLLGCSIRMQSKGTRAWLVEYIFCHCPLVSLNSREQGARRLVYFLYDLLSADKVGKTVDDFLADWNAIAYMYQAVISYVDALSQDSGHMLSNMAEVKTYSYRRLILGYGPNKANTVTILWRSLEKKFHLVFGVVGNTESATNPHSLVALQLKQLFNQHKSLPHLIKLLHETYTPLLSINKLTTIPILAGFNSRSPQSVLDFAIVPHSPTHIRISFRNLYCLDVHFRAEGLVAIRDGAYSLFDKSKAIEEFTPIPSLKAFLNKFVDDSACQIRRRSQSEDDNPPSPVSAMDSLDSFMSGHQKPNSPADRSQEGGLRFHHPVTPPSGSNPHTPASPHMGVLSNTYSSSPAAASFPLASPPSLQGNINPSPSMHHMGTPSPGTLLTANSPSNPLHVPSPGSFLPIASPSPQVHLPSPAGAFMGHPEGGSPYPSSGLSMPSPATQQWPRSPSMPRPSPGGRNLGTVQSPGSHPALHSPQGEHKGMVMSQTLTHLSRILPQRSWAAATPTLLTHGAFDVLCTPAPILNVPPIPGMSVCSPLERFMSCVYLRRSLQRLIQNEDNLQSIPCNEPGVVIFKVENFHCRVSQNSNHLQTLYLKITPTPEHKDHWSPEEFQILERFFDNRVVCNPYKPSAMLAFVRMLTSPPRILKDFIQIMRFELFPDRNYKWQVHWCLTIPPAASAIGPVGSVGFVVAKTKFLFFLQLTRQMYAGAEPLTLVLPLVHDIMNNTTQLAERPDVTPPPPNPVIAAALKRFSEFNQNPSECTIATSVRELLSNLVIPH
Length1473
PositionTail
OrganismStrigamia maritima (European centipede) (Geophilus maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Myriapoda> Chilopoda> Pleurostigmophora> Geophilomorpha> Linotaeniidae> Strigamia.
Aromaticity0.07
Grand average of hydropathy-0.131
Instability index55.31
Isoelectric point8.34
Molecular weight165059.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32769
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     239.10|      32|      77|    1062|    1093|       1
---------------------------------------------------------------------------
  998- 1030 (27.69/ 9.60)	PnSPAdrsqegglrFH.......HPV...........TPPSG.................SNP..HTPaS.P..
 1031- 1054 (30.27/11.30)	.......................HMG...........VLSNT..YSSS......PAAA.SFP.L..A.S.P.P
 1062- 1093 (71.95/38.75)	P.SPS.........MH.......HMG...........TPSPG..TLLT......ANSP.SNP.LHVP.S.P.G
 1101- 1135 (46.63/22.07)	P.SPQ.........VHlpspagaFMG...........HPEGG..S..........PYP.SSG.LSMP.S.P.A
 1140- 1172 (33.89/13.68)	PrSPS.........MP.......R..............PSPGgrNLGT......VQSPgSHPaLH...S.PqG
 1179- 1225 (28.67/10.25)	M.SQT.........LT.......HLSrilpqrswaaaTP.....TLLThgafdvLCTP.API.LNVP.PiP.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     405.42|     163|     273|      53|     325|       2
---------------------------------------------------------------------------
  132-  165 ( 8.71/127.70)	.................................................................................................................................................................................................LPNFHLP.CAVEVLTT.....GTYLRLPTCIRD.RIVPADP
  181-  318 (185.60/152.88)	IIQYRLVTSAD...LPAQMRSIK........IEYG.....QVTF...QVEHEFEVSLTVM..SDSLTDPWRLIDINVLvEDKETGDGKPL.......VHPLQVHFIHQLIQSRLLD.....NPKplhdLYSVlhSFCLSLQLEVLHSQVMR..LRTERLtgYIAVEYSPGVSL.............................................................
  335-  446 (119.54/53.74)	...............................IGY......KLTL...QI.HSYDSS...........KPLQIIHVPRL.GSKECQQADHAfksdqlsIEKLLVHTIYIRTKQRLHElkeeiKPK....LGSV..EFNIVGSPAVLHIPILQpcLRSEQL..LVSIDTHKGIFL.............................................................
  771-  904 (91.56/55.70)	VISYVDALSQDsghMLSNMAEVKtysyrrliLGYGpnkanTVTIlwrSLEKKFHLVFGVVgnTESATNPHSLV....................................................................................................alqlkqlfnqhkslphliklLHETYTPlLSINKLTTipilaGFNSRSPQSVLDfAIVPHSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.54|      28|      31|     929|     959|       5
---------------------------------------------------------------------------
  929-  956 (47.59/29.29)	IRDGAYSLFDKSKAIEEFTPIP.....SLKAFL
  960-  992 (44.95/19.95)	VDDSACQIRRRSQSEDDNPPSPvsamdSLDSFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.18|      54|     124|     555|     612|       8
---------------------------------------------------------------------------
  555-  612 (81.10/61.00)	LVTKLVPLEDEPAADTDA....QRSFLSISSLVQ.......FDAFTITHGPftIVDVDQIDKGygKRRL
  673-  737 (86.07/51.74)	LCIKLVKMPDCDGVDKNVlenlRHSLLGCSIRMQskgtrawLVEYIFCHCP..LVSLNSREQG..ARRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32769 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QIRRRSQSEDDNPPSPVSAMDSLDSFMSGHQKPNSPADRSQEGGLRFHHPVTPPSGSNPHTPASPHMGVLSNTYSSSPAAASFPLASPPSLQGNINPSPSMHHMGTPSPGTLLTANSPSNPLHVPSPGSFLPIASPSPQVHLPSPAGAFMGHPEGGSPYPSSGLSMPSPATQQWPRSPSMPRPSPGGRNLGTVQSPGSHPALHSPQGEHKGMVMSQTL
966
1183










Molecular Recognition Features






MoRF SequenceStartStop




NANANA