<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32763

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLIYSVSRKFSLKSQSNSDWMHEGNAVCVISSRNTIAFTSRTKVDDSVGKSWRCHVYVADLNLPWDVYRALSHNEEITCLEWDTSGSRLLVADKIGQIQIWMMKDYLLNDWFCFSTSQFPGEHILCAAWFHNGKKIVLNNEKKDSPHYTDKFLTVRFGPSIRHTGGRPREGCIAIGATGMICVVLLSMDGTTSTSCDSLGLLRTRLKVVDLCYGKNGDFLIAASDGSMCSAVHCYKVTLKIQQNDSRSAQSDGKSFQDKCVISSQSLPGFYPSCFNTNASERSADKKITHLRFVVREAADAVVVCASGNAGSIIELWELREKQIILNKMFLNTSTDNKLKTVSWQHHASQPSPTQVVALTTPRTSLYDSNPPPSYILAAYRDNSIKCFYRESLQFVFSITINPSLLHREEAGGIKHVRIGTTISDMQLTWTGSTLIALDSLSQIYLYRLSPITDPGGPVSVSYAVALFEYCLITGIDWWDILLGLRAQFIDQVCEKLTDSFNRQLPSQQQYLFFRFLTLKMSLYRCLNSGQNKAGDCSALLMLNAVATAFKSMLRPADLSSQDRGPAENLTVIMSGKPVDNITDVMIHLENKEFIVESATLQSMQQLIQWVADFSLYLLASLPQQTHSLIHFPGCGLINDLKALNTLRELLVIITMWGFIKQSCLPTFTKTSDSLDVLALLFRLLSKALQCGEPDDSLLDECCLLPSQVLIPALTLGVEAKGVTSPALFQNSLPLPFEYCSEPPFMNYRMEVNVVEGAITTNQFYDNVRHTYLGCKPSQYKQCARCSCVSMLKNMPKSTATKAWDQRWARTCPCGGHWKLANG
Length824
PositionTail
OrganismStrigamia maritima (European centipede) (Geophilus maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Myriapoda> Chilopoda> Pleurostigmophora> Geophilomorpha> Linotaeniidae> Strigamia.
Aromaticity0.09
Grand average of hydropathy-0.066
Instability index41.11
Isoelectric point7.83
Molecular weight92059.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32763
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.56|      15|      19|     340|     357|       1
---------------------------------------------------------------------------
  340-  354 (29.10/21.92)	LKTVSWQHHASQPSP
  360-  374 (28.46/12.48)	LTTPRTSLYDSNPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.25|      13|      19|     498|     510|       2
---------------------------------------------------------------------------
  498-  510 (23.84/17.61)	LTDSFNRQLPSQQ
  520-  532 (24.42/18.25)	LKMSLYRCLNSGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.83|      64|     241|     124|     200|       3
---------------------------------------------------------------------------
  124-  200 (92.85/95.77)	HILcAAWFHNGKKIVLnnekKDSPHYTdkfLTVRFGPSIRHtggRPREGCIA...IGATgmICVVLLSMDGTTSTSCDSL
  376-  442 (107.97/69.46)	YIL.AAYRDNSIKCFY....RESLQFV...FSITINPSLLH...REEAGGIKhvrIGTT..ISDMQLTWTGSTLIALDSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32763 with Med16 domain of Kingdom Metazoa
Unable to open file!