<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32758

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHPNFQTNGASLEDCHTNFFALTDLCGIKWRRLSVENVLCVDPLDDPVLLSFSKCLNADILSVWRRIQCTKNSCLLEPDQHHHLNHHHQQPHLHPHPNHTFYNKELWIFWYGEEPDLTNIICPELTEVEQGSWDSGLSYECRSLLFKALHNLIERCLVSRDFIRLGKWFVQPFDIQEKPAKSPSPHLSFSFSFFVHGESTVCATVDVRQHPAVFRLSPCHIQTAQGSHSGIQVILGPYGLCGILTGQTYKDNTHSTQKLLDEWRQFYPIDPKFGARDCLNERHYLPSLVEVVVGGVKMRYPSCYVIVVEGEDVQPTNSSSSLIMPLPSHHPTATKNTNVPPNSAMSWISMTPPTSPCDTSVFALGLNRKHSAGNSNRILSSGAGQMTSLSCSSSSADSNRLSRKVLGHVWQHSTLHVGTNTTTHSNAVENSNDADSIGHWDYMDPSQKLSCNCSKCRKSKQSTNQVKGNSLNGVASNQPSCSGKKGDRIDKQQPRHSRGNMPFHRRSPVNDDLASVDPDYMSQRVPVTTGNSSYQFKGIEMEFSRLLFVDFKGIFDVGCNPVATGGLPQLRTSILDPIASTASPHSSAPSPLVASHSQPASVTQTDPTMPTLSPHPPASKENDVSAEDIADKDNQSLPSNSNANTSPLELNKDGPKSVSDQGFSPFPNSLDQNKTYEILNWTQNQGQTCPALESGQGLKRPSLPFKVYEDQMEEELLSDGLYDYSALNAWLNHPVKKFKPEQKAEIKSTSRPGSVSENQASPMKEPLTPQSQLANDLLPAKAADPYEFEDEMPPVFSMSGFKSKNETSKEDEAPQSAPAANEASFPPSKDNKGLASNEAVASPPTPVNSSSKSKMLTSQDLRATYNDLDQLFDTSDDECSDDPFQAPTPTGSLKTIGSTTDEVTSKNKSSDIVGLHGPTDISRMFPTPPSLEHNPTPSPGIAPGSTDMTLMESDGIIMAKERSDIFPNCGSPSDENIMDWTYVFKPATQAKFVGSSKFAPLTNLPSQVSPPIFLPSQCVYKPSWQYPLPIIDKHAPSSHLVSVPSVEPIERIHSVASNRSMEPSPATFPTSLDHRMASSNYELASPASNASSYLNKNLNSIDNSLQTSQIPEAHSVLANVLLSDSMLNLFKDHNFNSCTMCVCQMDVYGADAGLYLSDASGANREALYKCTCGFSAVVNRKYAFRAGLFYEDEVEITGIREDLPDRRKPLHVLLGKEANDANVALDHVPQILLEILRNQCTTLAFSCSLSRKTGKAYQNVMASCYQNTLEISNGCESVMSALEQGRQMLDSISTCRLDDALKATCLHKWPHSPAKVPASSQDVMRLLRCLQPLLQDAIQKKRTAGLWETTYSVSGPLTWRQFHRLVGRAGTEDQCEPQPIPSLLVGYDKDWLALSPFAIKYWEKLLLEPYSSMRDVAYIVVAPDNDYVLSNVRTFFRELSSAYEVCRLGRHCPITKVLRDGIMRVGKTAAKKLADEPVDEWFNLLGDSSIANKLKLYAQVCRYRLAPHLSMQPMDRTLLESPVVASKPADKTVPVASPMPPPTPESQDRVPTPKSDTNEGSDSSQTAGPKEVPYSSSGGSAQEPWEQDDESQVPAVVVYMVDPFTYWSDHPEVHRLATLGLVRCYLQVIRCLPENIQNNIHLQIVPLESILEHTQNEGSGKQLDHLKALAFSVFSQCRRILIHQAAVKSLTGFGSAATAEAFLKTKDEKNVAAYRMYSPPFILAPMKDKQAELGESFGERKEKCTVLYTSYCLSEDQRWLLATCTDDRGEIMESIVINIEIPNRNRRKKASARKVALQKLMDWVLGVMSTGNMPWRLVIGRLGRLGHGWSSLLGRKFLLRASKHLKDICKQCLFLNAQDTPCVLSACLISTESDPILRIMHDQYTPDERFGSSCNSCDLSTPQDASCTHLLVFPTSATTQSTQATFLPDPGLADDDILDVLKEDLQEVDAIFDWADSPVASPVGSPRKDPVSLPGSPGLGVSGHQSPYQTNGAGRSSDGLSSDPQEENPQLLQQQPLALGYCVSTAKTGPLPKCFWTTCTQLEDTCPSFLKSALHIHSPSIQQSSDDPLQQHSHQHNYHPLDSSLTTDVLRYVLEGYNALSWLSIDPVSHDRRSCLPVHIQSLMQLYYALAPLV
Length2135
PositionMiddle
OrganismStrigamia maritima (European centipede) (Geophilus maritimus)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Myriapoda> Chilopoda> Pleurostigmophora> Geophilomorpha> Linotaeniidae> Strigamia.
Aromaticity0.07
Grand average of hydropathy-0.426
Instability index53.70
Isoelectric point5.85
Molecular weight235639.95
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32758
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.71|      29|      32|    1072|    1100|       1
---------------------------------------------------------------------------
  829-  858 (40.92/28.16)	SKDNKGLASNE.AVASPPTpvN...SSSK.S..KMLT
 1072- 1100 (49.76/36.37)	SLDHRMASSNY.ELASPAS..N...ASSYLN..KNLN
 1101- 1135 (33.03/20.84)	SIDNSLQTSQIpEAHSVLA..NvllSDSMLNlfKDHN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.07|      26|      28|     562|     589|       2
---------------------------------------------------------------------------
  562-  588 (41.16/21.51)	P.VATG.GLPQLRTSiLDPIASTASPHSS
  592-  618 (48.49/23.40)	PlVASH.SQPASVTQ.TDPTMPTLSPHPP
 1525- 1542 (30.00/12.26)	..VA...SKPA......DKTVPVASPMPP
 1959- 1978 (26.41/ 6.94)	P.VASPvGSPR.....KDPVSLPGSP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.32|      51|      52|     868|     919|       3
---------------------------------------------------------------------------
  868-  919 (85.27/47.36)	DLDQLFDTSDD.ECSDDPFQAPTPtGSLKTIGSTTDEVTSKNKSSDIVGLHG.P
  921-  973 (87.05/44.75)	DISRMFPTPPSlEHNPTPSPGIAP.GSTDMTLMESDGIIMAKERSDIFPNCGsP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.33|      11|      32|      31|      41|       4
---------------------------------------------------------------------------
   31-   41 (20.99/11.22)	WRRLSVENVLC
   65-   75 (23.34/13.26)	WRRIQCTKNSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.26|      25|    1280|     304|     329|       5
---------------------------------------------------------------------------
  299-  324 (40.37/25.70)	MRYPSCYVIVVEGEDVqPTNSSSSLI
  325-  349 (48.89/27.36)	MPLPSHHPTATKNTNV.PPNSAMSWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.67|      41|     347|     435|     480|       6
---------------------------------------------------------------------------
  390-  423 (36.73/13.48)	.............LSCSSSSAdsnRLSRKVLGHVWQHSTLHVGTNTT
  437-  480 (66.52/44.92)	SIGHwDYMdpSQKLSCNCSKC...RKSKQSTNQVKGNSLNGVASNQP
  516-  539 (32.42/ 9.25)	SVDP.DYM..SQRVPVT.........TGNSSYQFKG...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     191.93|      60|     341|    1544|    1610|       7
---------------------------------------------------------------------------
 1321- 1362 (49.69/17.93)	SQDvmrllRCLQPL..LQDAIQKKRTAGLWETTYSVSG...PLTWRQ.............................
 1547- 1608 (108.13/66.00)	SQD.....RVPTPKsdTNEGSDSSQTAGPKEVPYSSSGGSAQEPWEQDDE..SQVPAVVVYMVD.......PFTYW
 1997- 2037 (34.11/ 8.38)	...................................SSDGLSSDPQEENPQllQQQPLALGYCVStaktgplPKCFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.66|      30|     573|     162|     191|       8
---------------------------------------------------------------------------
  162-  191 (57.00/27.51)	DFIRLGKWFVQP...FDIQEK.PAKSPSPHLSFS
  724-  757 (45.65/20.67)	DYSALNAWLNHPvkkFKPEQKaEIKSTSRPGSVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.28|      48|     347|    1458|    1513|       9
---------------------------------------------------------------------------
 1458- 1513 (68.56/65.80)	VLRDGIM..R..VGKTAakKLAdepvDEWFNLLGDSSIANKLKLYAQVCRYRLapHLSMQ
 1808- 1859 (76.72/49.34)	VMSTGNMpwRlvIGRLG..RLG....HGWSSLLGRKFLLRASKHLKDICKQCL..FLNAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.62|      17|     399|      90|     107|      10
---------------------------------------------------------------------------
   90-  107 (32.33/25.04)	QQPHlHPHPNHTFY.....NKEL
  493-  514 (29.29/17.01)	QQPR.HSRGNMPFHrrspvNDDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.76|      27|     399|     630|     668|      11
---------------------------------------------------------------------------
  353-  381 (44.05/15.32)	PPTSPCDTSvfALGLNRKHSAGNSNRILS
  639-  665 (47.71/23.50)	PSNSNANTS..PLELNKDGPKSVSDQGFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.58|      18|      31|    1142|    1159|      17
---------------------------------------------------------------------------
 1142- 1159 (35.43/23.74)	CVCQMDV.....YGADAGLYLSD
 1171- 1193 (30.16/18.99)	CTCGFSAvvnrkYAFRAGLFYED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32758 with Med13 domain of Kingdom Metazoa
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