<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32753

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSGEEWRTPNFRQSVVIKIDEAIQRSGMATVKKGIEMESHVFAKAKTKEEYLGFVARLILHVRELNSKKGGTMAGNTVNNMQDPINALQNLARQGSGNQMMGGVLPPPIPQQSNPASEQERGGNIFGPRNSSPWFDFACWRKWNKVFRLPNLLRKTNVVIAELKYLQNRRNTLTCRLKLMMGGLGNTMGSSQMGGPQMAGTQLGGPQMGSGQMGTSQMGNAPIGTPQMGGPQMGTPMGGPQMGGGPQMGGPQMGAGQMGQRKPDGTPIMGQAGPGSFVGPRGVAPGQYLRQSPTPPTASPVQPPNMPTGNQMVPSPALVPSPNNPQLCGPQMRPIGMASSPSSGCLNTPGQPGASPCSLQEDAAYRDKIRQLSKYIEPLRRMIARVGNEDVEKLSKMKTLLDILTNPNKRMPLETLLKCEVVLEKVDLKRGDIVQPTREQHPLIEALRNHLQSPVINHTLQRTFGPCIEALFGSDIRNVPPTLKRRKIEEPPDDIPEVLQGEIARLDHRFKVSLDPMGNSGVGGGVQLVCWLDDKHLPCVPPVSVWVPEDYPASRPKCQLASHDHCATPFLTALSTALALRVASLPPHYTVSQLLDTWEMSVRQACSGTNSTSHTPTTALTAA
Length623
PositionTail
OrganismRhodnius prolixus (Triatomid bug)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Heteroptera> Panheteroptera> Cimicomorpha> Reduviidae> Triatominae> Rhodnius.
Aromaticity0.04
Grand average of hydropathy-0.440
Instability index57.03
Isoelectric point9.42
Molecular weight67347.87
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32753
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     294.25|      33|      33|     181|     213|       1
---------------------------------------------------------------------------
   70-  100 (31.27/ 7.30)	.G..G.TmaGNT.V...........NNMQDP...INALQNLA..RQGSGnQM
  101-  135 (43.65/12.94)	MG..GvL..PPP.I...........PQQSNPaseQERGGNIFGPRNSSP.WF
  181-  213 (71.49/25.61)	MG..G.L..GNT.MGS.........SQMGGP...QMAGTQLGGPQMGSG.QM
  215-  242 (44.07/13.13)	TS..Q.M..GNApIGT.........PQMGGP...QM.GTPMGGPQM......
  243-  258 (30.51/ 6.96)	..............G.............GGP...QM.....GGPQMGAG.QM
  269-  307 (30.63/ 7.01)	MGqaG.P..GSF.VGPrgvapgqylRQSPTP...PTA.SPVQPPNMP.....
  309-  337 (42.63/12.48)	.........GNQ.MVP.........SPALVP...SPNNPQLCGPQMRPI.GM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32753 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LGNTMGSSQMGGPQMAGTQLGGPQMGSGQMGTSQMGNAPIGTPQMGGPQMGTPMGGPQMGGGPQMGGPQMGAGQMGQRKPDGTPIMGQAGPGSFVGPRGVAPGQYLRQSPTPPTASPVQPPNMPTGNQMVPSPALVPSPNNPQLCGPQMRPIGMASSPSSGCLNTPGQPGASPCSLQEDA
2) SGNQMMGGVLPPPIPQQSNPASEQERGGNIFG
184
96
363
127










Molecular Recognition Features






MoRF SequenceStartStop




NANANA