<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32749

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceEQGSWESGLTYECRSLLFKALHNLIERCLLSRDFVRLGKWYVQPYDSSEKLLEKSGHLSFSFDFFLHGESTVCASVDVRQHPAVRTLLYSHLQQAQAVMHSAPPVNVILAPFGLAGTLTGQSYKEMDPYTKRLLDGWRQFYPIDKGCTDTSDLPPAVEVIVGGVKMRYPSTYVLITDLDESTSNLFPNHINNSFSTPMPPLRGYYYFNRLRHFLRIMHSYLHINYFAFTNLLSTFLNQRTTIDIISMLGRKTCSAFLHPNYLNGFSLSGGLSCLKNLQCLTITSANPSLTIVTSAWSYSCSIKESICTRRSKNRVVGGTVVPFHRRSTIQPSTVREFRSYHQPRSGKLNCPTVGQADSVPLPSVGSPASGGGSPVMTSVPPPDPTMPTLSPQPPPPQQSPLDEKVVSTPVDFNAPKSVSSISNQVTPTGHPCSAPTPPPLPPVQSFKRPVLNNTEYEDAVHQDNTPSQLLYDYTTLEAWLNYPVKRFKPQTHPSPRGPGDPYEFDEEGMTNVRMDTFKRGTNNIKVTIYGISSSLATSIAGTIIIIIIYFKEGSPSFLVNSRHVCANSIHNRKEDKSLVNGSANQGKIGTNLFTSEGLQVSYNDIDQMFEQNEDNSGDEALQVTPPSSNKPSEECGITSVMRQGCPPSGILRPEELVKMFPTPPSLEHNPVASPVAGLIGDTTIFSYYIIFKCANYYENFVAMQDWSYVFKPPTICKFVGSSKYAPFTMLPSHSLPVITLPTNCQYKPSWCLQQPAEKQNNTNGNTRSSSNNNSSGNCGSGGGAGGGGTPPPPPYSTSPANTPLPYPAPPKPIEPTQPNPPEADSLVVVVLLTDTSFNIFRDHNFDSCTLCVCNAGGKVVGNIRGGDAGMYLPMQGGGGTIGGGSPPWGTPTPHLSFDDEPIRCNCGFSAVVNRKLAHRAGLFIEDEFEITVKRLFGSESPKFCNLLQILRVSDLMYLSTFFESYSVGSLGKTEMELVQAQCLVMNSTSNALYRAANQYRPMSPMPAVNLLALRDSNHLSSVALEQGRLACSNNPPSMCKVANNINYRTGINFHRWGFLRARGPSCNQDIVRVMKQLQPLLQNAMQKKCSTRLWEAPIVSGPLTWRKFHRMALRGTDDRCEPQPIPSLMMGREKDWVSLAPYAVHLWDKLLLEPYSYSRDVAYVVVAPDNDFVLSKIRTFFKELSSTYEVCRLGRHCPITKVLRDGILRVGKTAALKLAKEPLDEWFSLLGDNNTSNMLKLYAQVCRHHLAPHLSQVPMDRTLLDPPEGATPVRSTPLERPASSPRSEQPNTPKQHDSQGNYFGIGHYGLSSSGSDEEGSEPPAIVVYLVEPFTLASDSPDLQRLACVALLRAYNTVLANVPETVKTNITLQVISLESVVELGRSGDTNRRSDHMRSLALSVFSQTRKTMYHGNSNIKALTGFGTAASNEVFFKNKDEKNRAPYKVYTPAYVLSKSRDKIAGNGETGVPTSDHCSVLYVSYCLSEDQRWLLASATDDRGLLLETITINIHIPNRSRRRKASARRAGLQKLMDFMLSVMSRSVTPWRLVVGRVGRIGHGELKGWSWLLSRKSLLKASKLLKDICVQCKLLYPHDVPCILSACLVSLEPDSSLRLMPDQFTPDERFSQASVKCQLSTPHDVTATHILVFPTSATTQSSQTAFQEQHINGLGDDELFSVLDDDIPEGMGDFNDIFSTWPETEAGGPRSPIGSPRARPDSAPGSPTSSLTPHHQSPYQHNASRNGDSSEEVGTVLQQPLALGFLVSTAPTGRMPRWFWSACPHLETACPAFLKNALHLHSTAIQQNSDELLQQQTAVAGHPLDSQYTTDVLRYVLEGYNALSWLALDSNSHDRLSCLPVHMQVLMQLYHMTSALT
Length1871
PositionMiddle
OrganismRhodnius prolixus (Triatomid bug)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Heteroptera> Panheteroptera> Cimicomorpha> Reduviidae> Triatominae> Rhodnius.
Aromaticity0.08
Grand average of hydropathy-0.316
Instability index54.06
Isoelectric point8.03
Molecular weight206499.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32749
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     274.57|      50|     509|     346|     395|       1
---------------------------------------------------------------------------
  346-  392 (84.13/31.71)	.......................................GKLNCPTVGQADSVP........LPSVGSPAS.GGGSPVMTSVPPPDPTMPTLSPQ
  393-  447 (65.47/23.10)	PPP.................................pqqSPLDEKVV....STPvdfnapksVSSISNQVT.PTGHPCSAPTPPPLP..PVQSFK
  793-  817 (32.42/ 7.86)	.PP.................................ystS....................................PANTPLPYPAPPKPIEPTQ
  818-  898 (59.90/20.53)	PNPpeadslvvvvlltdtsfnifrdhnfdsctlcvcnagGKVVGNIRGGDAGMY........LPMQGGGGTiGGGSP.....PWGTPT.PHLSFD
 1701- 1726 (32.65/ 7.97)	..................................................................GGPRS.PIGSP..RARPDSAPGSPTSSLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     271.75|     113|     270|     618|     773|       2
---------------------------------------------------------------------------
  296-  345 (54.06/11.44)	WSYSCSiKESICTRRSKNRVVGGTVVPFHRRSTIQPSTVREFR.SY..HQPRS.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  618-  685 (79.89/41.59)	.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................gklncptvgqadsvplpsvgspasgggspvmtsvpppdptmptlspqppppqqspldekvvstpvdfnapksvssisnqvtptghpcsaptppplppvqsfkrpvlnnteyedavhqdntpsqllydyttleawlnypvkrfkpqthpsprgpgdpyefdeegmtnvrmdtfkrgtnnikvtiygissslatsiagtiiiiiiyfkegspsflvnsrhvcansihnrkedkslvngsanqgkigtnlftseglqvsyndidqmfeqnednsgDEALQVTPPSSNkPSEECGITSVMRQGCPPSGILRPEELVkmFPTPPSLEHNPVA...SPVAGLiGDTTIF
  706-  757 (53.43/73.07)	WSYVFK.PPTICKFVGSSKYAPFTMLPSHSLPVITLPTNCQYKpSWclQQPAE.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1608- 1674 (84.37/32.00)	.....................................................kqnntngntrsssnnnssgncgsgggaggggtpppppystspantplpypappkpieptqpnppeadslvvvvlltdtsfnifrdhnfdsctlcvcnaggkvvgnirggdagmylpmqggggtigggsppwgtptphlsfddepircncgfsavvnrklahraglfiedefeitvkrlfgsespkfcnllqilrvsdlmylstffesysvgslgktemelvqaqclvmnstsnalyraanqyrpmspmpavnllalrdsnhlssvaleqgrlacsnnppsmckvanninyrtginfhrwgflrargpscnqdivrvmkqlqpllqnamqkkcstrlweapivsgpltwrkfhrmalrgtddrcepqpipslmmgrekdwvslapyavhlwdklllepysysrdvayvvvapdndfvlskirtffkelsstyevcrlgrhcpitkvlrdgilrvgktaalklakepldewfsllgdnntsnmlklyaqvcrhhlaphlsqvpmdrtlldppegatpvrstplerpassprseqpntpkqhdsqgnyfgighyglsssgsdeegseppaivvylvepftlasdspdlqrlacvallrayntvlanvpetvktnitlqvislesvvelgrsgdtnrrsdhmrslalsvfsqtrktmyhgnsnikaltgfgtaasnevffknkdeknrapykvytpayvlsksrdkiagngetgvptsdhcsvlyvsyclsedqrwllasatddrgllletitinihipnrsrrrkasarraglqklmdfmlsvmsrsvtpwrlvvgrvgrighgelkgwswllsrksllkaskllkdicvqckllyphdvpcilsaclvslepDSSLRLMPDQFT.PDERFSQASVKCQLSTPHDVTATHILV..FPTSATTQSSQTAfqeQHINGL.GDDELF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.21|      65|     992|      65|     155|       5
---------------------------------------------------------------------------
   65-  155 (103.19/96.55)	FLHGESTVCASVDVRQHPAVRTLLYSHLQQAQAV.MHSAPPVNVILApfglagtltgqsykemdpytkrlldgWRQFYPID.KGCTDTSDLPP
 1058- 1124 (112.03/61.70)	FLRARGPSCNQDIVRVMKQLQPLLQNAMQKKCSTrLWEAPIVSGPLT..........................WRKFHRMAlRGTDDRCEPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     251.04|      98|     880|     469|     617|       6
---------------------------------------------------------------------------
  483-  617 (133.22/147.11)	PVkRFKPQTHP..SPRG..PGDPYEFDEEgmtnvrmdtfkrGtNNIKVTIYGISSSLATSIAGTIIIIIIYFKE........................................................................................................gspsflvnsrhvcansihnRKEDKslVNGSANQGkIGTNLFTSEgLQVSY...NDIDQMFEQNEDNSG
 1272- 1331 (74.62/23.88)	PV.RSTPLERPasSPRSeqPNTPKQHDSQ............G.NYFGIGHYGLSSSGSDEEGSEPPAIVVYLVE............................................................................................................................................................................
 1455- 1499 (43.20/ 6.21)	..........................................................................pftlasdspdlqrlacvallrayntvlanvpetvktnitlqvislesvvelgrsgdtnrrsdhmrslalsvfsqtrktmyhgnsnikaltgfgtaasnevffknkdeknrapykvytpayvlsKSRDK..IAGNGETG.VPTSDHCSV.LYVSYclsEDQRWLLASATDDRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.99|      13|     507|    1335|    1347|       7
---------------------------------------------------------------------------
 1335- 1347 (24.42/15.31)	LASDSPDLQRLAC
 1840- 1852 (24.57/15.45)	LALDSNSHDRLSC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32749 with Med13 domain of Kingdom Metazoa
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