<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32745

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPINNNVGQEGSRGGSISLAILIDFIVQRTYHELTVLAELLPRKTDMERKIEIYNFSTRTRQLFVRLLALVKWANSASKVDKSARIMAFLDKQSMLFVETADMLARMSRETLVHARLPNFHIPAAVEVLTTGTYSRLPSCIRDRIIPPDPITLSEKKATLQRLNQVIQHRLVTGNLMPQMRNLKIECGRVKFHVEHEFEVSLTVMGDGPNIPWRLLDIEILVEDKETGDGKSLVHSLQVNYIHQVLQARLVDHPNPLAEVYSFLHFFCQSLQLEVLYSQTLRLCKDRLDGHIHVDEYTPGKCLAISYWRELTSKDPKSEVGYRLTVQVDSHDPARPLAVTHVPALGNKECQVADRAVRSELLSMERLLVHTIYMRTRARLHDLKLELQAILNNVDCVVGGSPAVLSVPVVQPCLRAEQLLVTVATHTGMLQAHIPKYDPPSIGELEAALNSDHSRLPNLISELRFWITQRRCEKTLQHLPATPHERLPLLLHPDHPMSKIGRHRMFIRLHRHRNIILIVELKEKDGCPLEMDLVFYLAVVKQSSIEDDPHDDTIETEIPKMYLKILTLIEFDTFVTTHGPFTPIDDQDRTDGKRKLAWKPESPPKKAKNPAYFIPELAHVVALCDERIPFVTLAQELTRREIAHQGLQVEANATALVLRIVQMPAPPGTAVSTGAYARLTKLLLSVSVRAHCNKGTSAWVVEFVMYGSPLATQHPKEQGMRRPVYFQYEMLPAETVQKTVDALLNDWAQIVHLYTLVEDLAEYFRIPKYNISSMVTVKSYSYSKLILGYGPDRAATVTVQWDPTAKAFTLVFGGGGNCIGAHSIMREQLEGELNRQRNLVQLIHLLNDTYSPLVSISKLPSAPQLGVQNNRPQVPVQTFTVMAESVSVIRVAYLGQYCLEIRLRAGGLVAVRDAAYSRFDRTTVVNEFTPTPGLKAFLSKYVDESVVFRRRSQSEDDNPPSPVALESGEVTGGFLGGVHRGPQSPAREGLRFHTPLTPPSNPHTPASPHTANISQAPQHQSFGSSPATTSSFNLASPPSLPPNINPSPSMLPHPSPGSGFLANSPSNPLHTSPMPISSPGPAVPLGHSPAGSLMHAVGHTDGSPFPSGQSMASPVASNWPGSPGVPRPSPRPGQSPHPALHSPTDPKTGLGGQRVLPQRSWAGAVPTLISHEALDILCTPSHHPLGLPGPQLAPLERFLGCVYMRRQLQRFIQNEDCLTNMTTTEPGVVHFKVDTLQCRVGLNPQHLESLHIKISALPDHKDLWTLEEIQILENFFETKAAAPPYKPNAINGFGRMLNVPQNVLKDFIQIMKLELIPSLIQQQQMKWSVQWCLRIPPSATPIVPTGMAAVLVCRQKILFFLQFTRVMGPAGAGGMGQYPTDSTSLVLPLIYDTTSNVTQLAEKRDSGPASAITTASMLLKRFLDCTGSMHTECSLYPAVRELLGNLILPSEP
Length1462
PositionTail
OrganismRhodnius prolixus (Triatomid bug)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Heteroptera> Panheteroptera> Cimicomorpha> Reduviidae> Triatominae> Rhodnius.
Aromaticity0.06
Grand average of hydropathy-0.173
Instability index51.34
Isoelectric point8.29
Molecular weight162168.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32745
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     313.19|      51|      55|    1049|    1099|       1
---------------------------------------------------------------------------
  970- 1006 (37.40/12.26)	..............PSPVALESGEVTGGFLG.....GVHRGPQSPAREGlrFHT.PL....
 1008- 1036 (47.63/17.85)	..PPS........N......PH.TPASPHTANISQAPQHQS...............FGSSP
 1049- 1099 (102.96/48.05)	SLPPN..I.....NPSPSMLPHPSPGSGFLANSPSNPLHTSPMPISSPG..PAV.PLGHSP
 1102- 1153 (77.84/34.34)	SLMHA..VghtdgSPFPSGQSMASPVASNWPGSPGVP.RPSPRPGQSPH..PAL....HSP
 1165- 1205 (47.36/17.70)	VLPQRswA.....GAVPTLISHEALD..ILC.TPSH..H....PLGLPG..PQLaPL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.58|      39|      55|    1228|    1280|       2
---------------------------------------------------------------------------
 1228- 1267 (63.17/52.56)	LTNMTTTEPGVVHFKVDTLQ..CRVgLN.PQHLESLHIKISAL
 1282- 1323 (59.41/24.41)	LENFFETKAAAPPYKPNAINgfGRM.LNvPQNVLKDFIQIMKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.29|      54|      57|     419|     474|       3
---------------------------------------------------------------------------
  419-  474 (83.84/55.51)	VVQ.PCLRAEQLLvTVATHTGM.LQAHiPKYDPPSIGELEAALNSDHSRLPNLISELR
  477-  532 (87.45/50.01)	ITQrRCEKTLQHL.PATPHERLpLLLH.PDHPMSKIGRHRMFIRLHRHRNIILIVELK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.36|      35|      67|     317|     353|       4
---------------------------------------------------------------------------
  317-  353 (56.28/53.34)	YWRELTS.KDPKSEVGYRLTvQVDSHDPARPlAVTHVP
  383-  418 (57.07/43.19)	YMRTRARlHDLKLELQAILN.NVDCVVGGSP.AVLSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.24|      50|     672|      30|      85|       7
---------------------------------------------------------------------------
   30-   85 (71.21/79.31)	AILIDFIVqrtYHelTVLAELLPRKTDMERKIEI.YN.FSTRTRQLFVRLLaLVKWAN
  708-  759 (83.03/67.58)	AWVVEFVM...YG..SPLATQHPKEQGMRRPVYFqYEmLPAETVQKTVDAL.LNDWAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.15|      50|      78|     155|     204|       9
---------------------------------------------------------------------------
  155-  204 (86.22/60.64)	IIPPDPITLSEKK..ATLQ..RLNQVIQHRLVT.GNLMPQMRN.LKIECGRVKFHV
  230-  285 (64.93/43.52)	ILVEDKETGDGKSlvHSLQvnYIHQVLQARLVDhPNPLAEVYSfLHFFCQSLQLEV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32745 with Med14 domain of Kingdom Metazoa
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