Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MMGDHQFRKVEQYSPKSSPRGARSPVVSRQDSTGTLKTTISLGKNPSIVHSGPFYLMKEPPAEGELTGAVNLMAAYGLEHTYSKFSGKKVKEQLSSFLPNLPGIIDTPGHQDNSSLRSVIEKPPIGGKELRPLTSVQLAGFRLHPGPLPEQYRYVSQAPTKKHKSRHKKHKHKADGAGGGGGAGGGELSASEGGVDTHEKKH |
Length | 202 |
Position | Head |
Organism | Rhodnius prolixus (Triatomid bug) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Heteroptera> Panheteroptera> Cimicomorpha> Reduviidae> Triatominae> Rhodnius. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.776 |
Instability index | 48.38 |
Isoelectric point | 9.79 |
Molecular weight | 21693.28 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32743 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 38.24| 11| 15| 109| 119| 2 --------------------------------------------------------------------------- 109- 119 (19.37/13.03) GHQDNSSLRSV 126- 136 (18.88/12.52) GGKELRPLTSV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GELSASEGGVDTHEKKH 2) MMGDHQFRKVEQYSPK 3) QYRYVSQAPTKKHKSRHKKHKHKADGAGG | 186 1 151 | 202 16 179 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab