<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32738

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDVLYTLRRKHIASNNDFIYSLHEGTSLCCISVKNIVAFTTRTELEDTLGKTYGSHVYVSDLNTPWHSHRVTSKSGTVLALEWDAPGERLLIATDGGDISIWTPREHVLNIWTCIGHSSFHGEAIIGAAFFHNGRKISIIAEKRDSVVYSEKMSHVKFSPSVRGFGGGAGEGCIVMTGTGMVGGILLPKEAGAKIITAAESLAATRVTLSIVDISYGKNGQFVVAVSNGDVCRVQCYRVSVKYADDRLHISSQALPSFFLQSFKSNGPGGKVTGLKFVTREDADSLVVCANTVHGGVVEVWQLTERPVSLHRVFQPPPDPFKTVAWQFECSYSTNSPITCVTTCKQALTTYAPPPSYVMIVTNDATLHCLYRDSLKLVGTRSIASAWQEDTIKHQRLSTKITHMDLTWLGCALALVDSHGQLYVVKVPPILEPGVGMTVNVASGLLEYCLVTGTDSWDVLVSIQLSIVDAITDRITDNFNRQPLSVQQFYYAGHLALRTSLARLTQNGQTKVADLTSLLMLHSVSTAFTSLLRPSDLSSHDKGPAESLAALLSDNLTDIDKVLLHLEGKEFTVEPSTLQSLQQLIQWTADLALNILARLPEQYKSTSVSCSELGRDIKAVNTLRQLLVIIRVWGLLRTTCLPMFVRSAENLDVLALLFKLLSKLVQTHEPDDTLIDDCCLLPSQVMIPQMNPSTPIVCIASPSFAYQSFPMQLEYGVEPEFLVFEPDQNILEGCLATDQNVDTLRHIYLGKQPYLVKQCCRCGGKAQVQVSTRTAPIRAWDQRWLRSCRCGGTWRIH
Length797
PositionTail
OrganismRhodnius prolixus (Triatomid bug)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Heteroptera> Panheteroptera> Cimicomorpha> Reduviidae> Triatominae> Rhodnius.
Aromaticity0.08
Grand average of hydropathy0.039
Instability index32.88
Isoelectric point6.66
Molecular weight87820.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32738
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.17|      19|      36|     314|     332|       2
---------------------------------------------------------------------------
  314-  332 (41.61/25.02)	FQPPPDPFKTVA..WQFECSY
  351-  371 (30.56/16.55)	YAPPPSYVMIVTndATLHCLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     225.74|      65|     343|     199|     265|       3
---------------------------------------------------------------------------
  199-  265 (102.33/94.02)	AESLAATrVTLSIVDIS....YGKNGQFVVAVSNgDVCRVQCYRVSVKY.ADDRLHISSQALPSFFLQSFKS
  545-  605 (82.10/64.37)	AESLAAL.LSDNLTDIDkvllHLEGKEFTVEPST.....LQSLQQLIQWtADLALNILAR.LP....EQYKS
  677-  709 (41.31/27.14)	...................................DCCLLPS.QVMIPQ.MNPSTPIVCIASPSFAYQSF..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.50|      18|     322|     410|     428|       4
---------------------------------------------------------------------------
  410-  428 (29.74/18.83)	GCaLAL...VDSHGQLYVVKVP
  733-  753 (29.77/14.77)	GC.LATdqnVDTLRHIYLGKQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.25|      15|      16|      83|      97|       5
---------------------------------------------------------------------------
   83-   97 (27.81/17.44)	WDAPGERLLIATDGG
  102-  116 (31.44/20.66)	WTPREHVLNIWTCIG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32738 with Med16 domain of Kingdom Metazoa
Unable to open file!