<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32732

Description Mediator of RNA polymerase II transcription subunit 1 (Fragment)
SequenceDKTKDWQMEMVMEKIRSKANQYKSFFESSKTLRMTMLEKRYPIDAVERSQLQKCLDTLQQNIKVTTHQAMIERLESVSRQLGLKFVTGPSGLDLFISSDMFYLEVVLESNGGVKDVKIHHEGRGEQQSCEELVACLTRRDFADFTAQLEGLASIYQLNAEKKVKCKAFTALTSLETDLSTLASLQTYMKDPLTVVHNSPIGLLEKRRGGHAMKLTYFVSPYDLLDPSTRTSKTLTMEGVTVGHSVSVCMESSTAHKLQTAPLITISRGSDGNSWPVYGNVTATNSITVAGTFVLNLNKPMPVCMSLINSIQAVTQAQCTDVTRSHPLLSLITQHASGGLADSANSKGLFVNVGDQHHCYLMSESRNLEGVLVNSVPFTHPAHVPQIVTFLRQQALFNAIIASCVRPNTKQDFEKMIMLEVTPLSWQHLSISLEHPLEEGMATIELDLADINNIVCKNIVSLASTPSVGSFSSFGQTILSTEFLFTCLSIPVTMRSLIKQWNQQSQLLTPIYNGIGGSGGGGGSSGSGGGNNGNSSDYDPDLKIKLEPGLGGLVSRHHQGNFVSDQSLSDPGFENFSSPMEEQHSLGQFPDLASTSGLLDSTKMSKRKRRSGEPWRSPKRKHEDGGTVESSSSDSTPLGTPTSREPSDNREPTPTSTASGLEFSAFCDLENSGTGEKSQSDVDNEEVIPVRTSRMMIDILFDLENKNLVPPSVSITPINSNQMSTPNFTSVLSGMGLERRPGIEIIPISSTPTTSLPSSITITPITTKPVIEERSKERKSGRSKSEDKGKLDKKRKRKREESPMGPPEKVPSKSDPLSKPVTVSIKPADSSSSPRPSSPAGTVSRKYTSSPTHTSPLALVGKSSPGSSSKSKPPPQQSPKHSPAYATSSPKNNLTSSPKHGTSSPKHQSSSGKPSMSALKSAVSSPSKSESKTKSKEGRDKDRKSFSSSSGHSSPKLKSASVKLKQLDLSTIDVPQSLQSGGSTPPSTGDGGKPSAGQSRNRKNSLSAVIDKLKSAQHCGDEGNGKEKKENKDRSTSGKVDSKSTNKPGETKSGEYMVKPSSDGMKITINKTRTKDSSKVKSSSSSSSSSSSGSASPKMHTGLKSGVNSGPASKKPNLPGQKSGSPGIKTSSSSSSVSTSSSSSGKSLVKSSLSLQKSIKPTGSPKTSDPNRTRDKPRVSKAPDKSVFSSSKSDSRKMSPSALREDSEYKSLPTSTSQLVVEGLVKSLDTKFQIPKLSARNASASQSDDKKTKDVENRSSDSPKVLDLVSKDTKYGSGSKNSEDSRVSTGDSKVKPISTSTAVTIGSSSPKLSSSKIATEVTDSPNISIIPVPTEKEDKECKGNNVTVTKAAELLLDFSATSKIETRLLSMTDRAMGAIPLRRNTPPPPPPPPAFPGSPSVSVHIVKSPAPPSDLPLVIQSPHSSSPCITDDELMDEALVGIGK
Length1443
PositionMiddle
OrganismRhodnius prolixus (Triatomid bug)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Paraneoptera> Hemiptera> Heteroptera> Panheteroptera> Cimicomorpha> Reduviidae> Triatominae> Rhodnius.
Aromaticity0.04
Grand average of hydropathy-0.595
Instability index60.18
Isoelectric point9.36
Molecular weight154243.78
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32732
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     438.53|      50|      51|    1076|    1125|       1
---------------------------------------------------------------------------
  616-  658 (41.33/10.31)	SPKRK...HEDGGTVESSSSDSTP..........LGT...PT...S..............REPSdnrEP..T....P.TS....TAS
  781-  829 (45.34/12.16)	RSKSE...DKGKLDKKRKRKREESPMG.PPEK..VPSKSDPL...S...............KPV...TV..S....I.KP....ADS
  830-  866 (41.14/10.22)	SSSPR...PSSPAGTVSRKYTSSPTHT.SPL................................A...LV..G....K.SS....PGS
  867-  897 (41.53/10.40)	SSKSK...PPPQQSPKHSPAYAT...............SSP....................KNN...L...........T....SSP
  899-  946 (33.28/ 6.59)	....H...GTSSPKHQSSSG..KPSM..SALK..SAVSS.PSkseS..............KTKS...KE..GrdkdR.KS....FS.
 1006- 1055 (40.50/ 9.92)	SAVID...KLKSAQHCGDEGNGKEKKE.NKDR..S..TSGKV..dS..............KSTN...KP..G....EtKS....GEY
 1076- 1125 (85.50/30.69)	SSKVK...SSSSSSSSSSSGSASPKMH.TGLK..SGVNSGPA...S..............KKPN...LP..G....Q.KS....GSP
 1128- 1164 (35.18/ 7.47)	KT.......SSSSSSVSTSSSSSG.......K..SLVKSS...........................LS..L....Q.KSikptGSP
 1175- 1243 (32.58/ 6.27)	KPRVS...KAPDKSVFSSSKSDSRKMSpSALRedSEYKSLPT...StsqlvveglvksldTKFQ...IPklS....A.RN....ASA
 1261- 1309 (42.16/10.69)	SPKVLdlvSKDTKYGSGSKNSEDSRVS.TG.D..SKVK..PI...S..............TSTA...VT.iG.......S....SSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     356.02|     106|     246|     244|     349|       2
---------------------------------------------------------------------------
  244-  349 (178.69/105.26)	SVSVCMESSTAHKLQTAPLIT.....ISRGSDGNSWPVYGNVTATNSITVAGTFVLNLNKPMPVCMSLINSIQAVTQAQCTDVTRSHPLLSLITQHASGGLADSANSKGLF
  488-  598 (177.34/104.40)	SIPVTMRSLIKQWNQQSQLLTpiyngIGGSGGGGGSSGSGGGNNGNSSDYDPDLKIKLEPGLGGLVSRHHQGNFVSDQSLSDPGFENFSSPMEEQHSLGQFPDLASTSGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.71|      34|      36|     706|     741|       3
---------------------------------------------------------------------------
  706-  741 (56.92/32.74)	NLVPpsVSITPINSNQMS...TPNFTS.VLSGMGLERRPG
  743-  780 (48.79/22.16)	EIIP..ISSTPTTSLPSSitiTPITTKpVIEERSKERKSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.19|      37|     287|     149|     186|       4
---------------------------------------------------------------------------
  149-  186 (55.50/46.77)	EGLASI.YQLNAEKKVKCKAFTALTSlETDLSTLASL.QT
  438-  476 (53.68/39.71)	EGMATIeLDLADINNIVCKNIVSLAS.TPSVGSFSSFgQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.56|      13|      34|    1378|    1390|       9
---------------------------------------------------------------------------
 1378- 1390 (26.42/10.86)	IPLRRNTPPPPPP
 1414- 1426 (23.14/ 8.42)	LPLVIQSPHSSSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32732 with Med1 domain of Kingdom Metazoa
Unable to open file!