<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32724
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MSGVPSTQDLLSQALNSKIIPNQEYLLQGSILDSASDHLFQRLKGLCDNVESGPQLFNDHELCLSLRAPNQPQPLMLRVRRSLDVDAPYQLRYIGQPEVGDRTRPTLVRSSIDVGCTSTVIDFLTELGCKIDFEYFSKGYMFRKGRMKITMSKILKVGKGDEALSQSQLVELSVLAPTGQDAIGEEMKSFAEQLKPLVQLEKIDYKRLGTMP |
Length | 212 |
Position | Head |
Organism | Megaselia scalaris (Humpbacked fly) (Phora scalaris) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota>
Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Platypezoidea>
Phoridae> Megaseliini> Megaselia.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.279 |
Instability index | 48.42 |
Isoelectric point | 6.16 |
Molecular weight | 23696.06 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP32724
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.22| 18| 28| 66| 85| 1
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66- 85 (29.84/22.31) LRAPNQPQ......PLMlrVRRSLDV
91- 114 (27.38/14.47) LRYIGQPEvgdrtrPTL..VRSSIDV
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