<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32715

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMQREEKQWEMTLEQILSRLNDLKLSIGNMIQVLETQYETINWPTFLDNFALISSHLTGISKILNRRDMGGCLLRNRTFLPLTLSQDRDEHLVQIMKDVTKPDPTAEARMIAHEQKANSLNADTANKQVMQFNKVVGHISDIISEHRDKFETESSARAGIQQTSSMTDTQALVAAVGIGKGLLKMPMAPMGGGPGQVMLPPGGIRPPSMMSSLVWTKMVKKPKGLLVLEEMAAAERQLQEPFLRHGEHSNSNTTGSSEMVPNLDLTSNESYPSTDNELWYGKACEMSKMITKPDAFKAWLSAKKKSEFYESMRKKALEEELEKTKAEKKRIADEKYKEWLKKKSATSLVKKKSSTQLTSPKQTRSQEEIDHNFEQWLLKKAEYDRHLKERIREELEQKRILEDTKKKISEKIYNKWLETAPYKPKPVPMNKGLESLRGSTTEIHKNPEPWRTVIGEEVDDLSTCEEVPEMRF
Length471
PositionHead
OrganismMegaselia scalaris (Humpbacked fly) (Phora scalaris)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Platypezoidea> Phoridae> Megaseliini> Megaselia.
Aromaticity0.06
Grand average of hydropathy-0.744
Instability index46.73
Isoelectric point8.60
Molecular weight53908.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32715
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.71|      37|      37|     302|     338|       1
---------------------------------------------------------------------------
  268-  298 (28.55/11.27)	....ESYPS.....TDNELWYGK...AcEmSKMIT.KpDAFKAW
  302-  338 (60.86/30.95)	KKKSEFYESMRKKALEEELEKTK...A.E.KKRIA.D.EKYKEW
  340-  375 (47.39/22.74)	KKKSA..TSLVKKKSSTQLTSPK...Q.T.RSQEEiD.HNFEQW
  377-  415 (49.91/24.28)	LKKAE.YDRHLKERIREELEQKRileD.T.KKKIS.E.KIYNKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.67|      29|      41|     158|     198|       2
---------------------------------------------------------------------------
  158-  187 (45.30/56.03)	GIQqTSSMTDTQALVAAVGIGKGLLKM.PMA
  202-  231 (48.37/26.25)	GIR.PPSMMSSLVWTKMVKKPKGLLVLeEMA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32715 with Med8 domain of Kingdom Metazoa
Unable to open file!