<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32694

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMATAADNQNTSSFPPPPMQYINKYTDDNVKFGRAPKPPPPIKDSYYLMFGVEFRADDQIIRPLESQSLVRLHPHNYDHKRELKKLNYSILVNFLDLLDVLVKAPESRRRLEKIDDLTLLFIHMHHLINEFRPHQARETLKVMLENQKEQRIEITERFEKRAEQVKDLLNATIAALPDDSQLDTKLLINKSYPSLLPAMQPPRDKYTGLVNPSGSAITATSNNNNNNSSILSDEIISLSSARSSFNDSDFDDDDDDVMNRIVHAKKYRKPKKKLKKKIKKEYPNDSSNLNNSNNTDFSNTSSNMFYDDLGTIADDDDDGDDNADFTADDDAGAKDESVDGGAKDDMMRKVVDGLN
Length354
PositionMiddle
OrganismHelobdella robusta (Californian leech)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Clitellata> Hirudinea> Rhynchobdellida> Glossiphoniidae> Helobdella.
Aromaticity0.07
Grand average of hydropathy-0.842
Instability index37.99
Isoelectric point5.15
Molecular weight40228.37
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	RuleBase:RU364060
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32694
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.33|      22|      68|     201|     232|       2
---------------------------------------------------------------------------
  201-  232 (30.05/31.78)	PRDK........YtglvnPSGSaitatSNNNNNNSSILSD
  269-  298 (35.28/16.67)	PKKKlkkkikkeY.....PNDS.....SNLNNSNNTDFSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.98|      17|      20|     306|     323|       4
---------------------------------------------------------------------------
  306-  323 (26.92/20.41)	DDLGTiADDDDDGDDNAD
  328-  344 (30.05/17.95)	DDAGA.KDESVDGGAKDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.29|      15|      68|      95|     119|       5
---------------------------------------------------------------------------
   77-   91 (24.19/27.11)	DHKRELKKLNYSILV
  105-  119 (23.10/ 6.94)	ESRRRLEKIDDLTLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32694 with Med7 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDGDDNADFTADDDAGAKDESVDGGAKDDMMRKVVDGL
2) KKLKKKIKKEYPNDSSNLNNSNNTDFSNTS
3) PAMQPPRDKYTGLVNPSGSAITATSNNNNNNSSILSD
315
271
196
353
300
232










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKLKKKI
2) MNRIVHAKK
3) QYINKYT
4) SYYLMFG
270
257
19
44
277
265
25
50