<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32693
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MPPIEYANASQNSVMFGNVVPLSTLMEFLIQRTYHELSILSELLLGKNDLERKIEICQFANRTKQTFVRLLALVKWTNSANKVDKCARIFSFLQQQQLLFVETADCLARMARETLVHARLPSFSLPCAIDVLMTGTYPRLPFCIKEKIVPPEPLPPLEKKRVLTKLTQVIEYRIVMNDLPHSMCKPVIENGRVKFTVDHEFEVFLTLMGDTPNLPWRLLNIDILVEDYESKNGRSLVHPQQVAFIHEMVQSKLLESEQPLHDLYNCLLSTVTNFLFPDFFCQSLQLEVLYFQSFTLIKEKFGDFVKVDEYNLGRNLIISYWRDSGKSQKLYPTGCKLNIYVDEKNTSKPLFISHSPVLYGEDGMKSMKQINELKRELEMFTSAKCSIIDFPPLMYLTVSKELEEIIITVDMMKGLFSVTKINSANPYLDALEDSLNGDRKDIGQIFAAIRVFQYKCMYESMLVSHRLQYTDYSQKPTDLHATFGKNFFSVAFPNTNKYTMIIKFSNKDKACVQHFLLKVREMDPVSKRLNYSEMIFVDPAKILESNSINALLNSKKSKASVPLMHMFSNIYSHMEDIILFDGLNDELGLLGIYNSNHLPDPCGIGYSLQITKGISFDTSDAAKIPFNSHDMTVTFRLIKKDKCYWCVLVTASENPIFSLPTLNEQYTRCFLKVYDVSDVKKVVSSFATDWNVNYQMLKIVHDMSYQYNDHLVQGEQTLPSQFYIESFSFNKLVISYGPKRHFLVSVEYCNNTKSFQVTFGSHADSVISNPHSLVSAHLSHHLNKSKSLVLFCKLLAQTCEVNEQLYKLNTTPLVWTKVNWMLPVQNYTVVAQSLFHYRIYYFYPLFCMELSCPNKTYITFKDSSISPNAKLNDASLSGFQAFLCASSDSLCSSNDVTGSIDENNAQHNVVGMSDVDNFLLSDLQMNVFRSAAEKIHQPFLENYVTRDLLTKLMTPINNVSPLDKYLGVQYFRRHLQRIIKSDDSQLIQIPTTEAGVLMFKSDLSGLQLKFNASLVSSPLKIFPLQDTPWDMDDLFSLEKFFEVKVLSHPYKPSNLEAFCSLLKMHFHILKDFINIFRMELNADKNMRWFVQLLLTFPSGFDYNMGANAIVISRKIVFILLLTCNVGHPSYAESTPSSNQPPNVILPLCYDSATNTVQLVENHKQNVNQMSVVANILKRFSDFLVKPNECSILPAIREIIANLT |
Length | 1203 |
Position | Tail |
Organism | Helobdella robusta (Californian leech) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Clitellata>
Hirudinea> Rhynchobdellida> Glossiphoniidae> Helobdella.
|
Aromaticity | 0.11 |
Grand average of hydropathy | -0.074 |
Instability index | 37.03 |
Isoelectric point | 6.79 |
Molecular weight | 137846.94 |
Publications | PubMed=23254933
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP32693
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 111.97| 31| 128| 398| 429| 1
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398- 429 (50.76/34.47) VSKELE..EIIItVDMMKGLFSVTKINSANPYLD
485- 500 (19.77/ 7.16) .................KNFFSVAFPNT.NKYTM
525- 553 (41.44/23.24) VSKRLNysEMIF.VDPAKILES....NSINALLN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 202.66| 65| 266| 846| 919| 3
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846- 919 (95.82/78.86) FCMELSCpNKTYITFKDSSISPNAKLNdASLSgfqafLCasSDSLCSSNDVTGSIDENNAQHNVVG..MSDVDNFL
1117- 1183 (106.84/62.02) FILLLTC.NVGHPSYAESTPSSNQPPN.VILP.....LC..YDSATNTVQLVENHKQNVNQMSVVAniLKRFSDFL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.23| 25| 266| 294| 335| 4
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305- 329 (46.55/57.25) VKVDEYNLGRNLIIS.....YWRDSGKSQK
339- 368 (40.67/12.93) IYVDEKNTSKPLFIShspvlYGEDGMKSMK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.84| 30| 326| 229| 265| 10
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190- 227 (39.92/24.34) NGRvkfTVDHEFEV.FLTLMGDTpnlpwRLLNIDILVED
232- 262 (48.92/36.36) NGR...SLVHPQQVaFIHEMVQS.....KLLESEQPLHD
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