<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32689

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDISRQNSPKSSPRGSRSPAYPRQDTTGTLKTTITLGKKPSVFQGGTFYLMRDPPEPSDLTGLTNLMAYHGLEHSYNKFSSRKVKEELSAFLPNLPGNIDQPGSVDNSSLRLLMEKPPIVGKELIPLSGNALKGFKLYSGPLPEQYRLMHQAVQPRKKHKKSKREGKETGIPESQGNNLDGGSGSEYKKIKKNKKTDEERKKRKKEKKKRKEKEKNGGLMIQQPISLDTAATANNSNPGINSSSSSLIKLS
Length252
PositionHead
OrganismHelobdella robusta (Californian leech)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Clitellata> Hirudinea> Rhynchobdellida> Glossiphoniidae> Helobdella.
Aromaticity0.05
Grand average of hydropathy-1.033
Instability index46.53
Isoelectric point10.02
Molecular weight27863.44
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IBA:GO_Central
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32689
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.95|      37|      43|     122|     164|       1
---------------------------------------------------------------------------
  122-  164 (55.72/39.75)	GKEL.IPLS.GNALKGfklYSGPlpEqYRLMHQAVQ...PRKKHKKSK
  167-  208 (53.23/23.94)	GKETgIPESqGNNLDG...GSGS..E.YKKIKKNKKtdeERKKRKKEK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32689 with Med19 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQYRLMHQAVQPRKKHKKSKREGKETGIPESQGNNLDGGSGSEYKKIKKNKKTDEERKKRKKEKKKRKEKEKNGGLMIQQPISLDTAATANNSNPGINSSSSSLIKLS
2) MSDISRQNSPKSSPRGSRSPAYPRQDTTGTLKTTITL
145
1
252
37










Molecular Recognition Features






MoRF SequenceStartStop




1) LMIQQPISL
2) SEYKKIKKNKKTDEERKKRKKEKKKRK
3) TFYLMRDP
220
186
48
228
212
55