<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32687

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMAESNIGSEVVSAETRQKIVEQFKLHISGATAVELENSIYARSSNHKDYMADVHASYKKLEAMKQLRPLQQQQGGTSTMSVPQNFVDPALHQQSLSDPINALQHLTKQGQSPLQSNQMVRPPGQVPAVLQPRYPTHPGAVPGGLGVRIVGQQVLKGDVLMGQQQQNRMPAVVQANQMMASDQFQGGIPGQFQSHMQSRMQQFNQQVAGSPGGGQAQQHLLPSPGSSMTVPSPSNLNAVNPSPSMQQQMMIGLSPSSRMSLPSPGSHLNTPASEEQEYLQKWEQLQKYLEPLKKMILKIDKDEDRKMDMNKMKNLLDILSDRSKRLPLSTLLKCESVLERQLNVPSSPSAAGHSGSAGGSSSSAEEPLAMGQELYDVLKANIKRPDFHDVLKKTFEGAVRLIPMPEHIEYKRTKSKLPKYSPAVRPLRKTAESYTSSDLILQRNVLGNDEINESIQNEVLYLDDRYLIQLDTMHITGSESILLSCTFDDLNLPKVPSLIIQVPSTYPNSFNPQVLYLENNLETSPFFDRLRANMLREVGRLGKKHSLTELLVLWERVIKMSITTNTSLEVTSEYPHLPESSISD
Length583
PositionTail
OrganismHelobdella robusta (Californian leech)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Clitellata> Hirudinea> Rhynchobdellida> Glossiphoniidae> Helobdella.
Aromaticity0.05
Grand average of hydropathy-0.507
Instability index70.46
Isoelectric point6.97
Molecular weight64744.02
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32687
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.43|      22|      28|     210|     232|       1
---------------------------------------------------------------------------
  121-  143 (26.76/ 8.00)	P.P..GQVPAVLQPRypthPGA...VPGG
  184-  202 (24.71/ 6.93)	QGGipGQFQSHM........QSRM..QQF
  210-  232 (40.96/18.17)	PGG..GQAQQHLLPS....PGSSMtVPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.89|      16|      16|     291|     306|       2
---------------------------------------------------------------------------
  291-  306 (25.43/20.47)	LKKM..ILKIDKDEDRKM
  308-  325 (19.85/14.32)	MNKMknLLDILSDRSKRL
  327-  341 (21.61/16.25)	LSTL...LKCESVLERQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     247.05|      81|      90|     390|     479|       3
---------------------------------------------------------------------------
  390-  479 (115.25/102.35)	LKKTFEGaVRLIPMPEHIeyKRTKSKLP.KYSPAVRPLRKTAESYTSSDLiLQRNVL...GNDEINESIqNEVLYLDDRYLiqldTMHITGSES
  482-  566 (131.80/85.91)	LSCTFDD.LNLPKVPSLI..IQVPSTYPnSFNPQVLYLENNLETSPFFDR.LRANMLrevGRLGKKHSL.TELLVLWERVI....KMSITTNTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.69|      25|      56|      92|     118|       5
---------------------------------------------------------------------------
   92-  118 (40.16/25.99)	QQSLSDPInaLQHLTKQGQSP..LQSNQM
  151-  177 (39.53/19.97)	QQVLKGDV..LMGQQQQNRMPavVQANQM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32687 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAMKQLRPLQQQQGGTSTMSVPQNFVDPALHQQ
2) KGDVLMGQQQQNRMPAVVQANQMMASDQFQGGIPGQFQSHMQSRMQQFNQQVAGSPGGGQAQQHLLPSPGSSMTVPSPSNLNAVNPSPSMQQQMMIGLSPSSRMSLPSPGSHLNTPASEEQE
3) SDPINALQHLTKQGQSPLQSNQMVRPPGQVPAVLQPRYPTHPGAVPG
61
155
96
93
276
142










Molecular Recognition Features






MoRF SequenceStartStop




NANANA