<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32685

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAENQNGCSLEDCHTNLFALADLSGIKWRRLNAQSDTSYTADPLDDPVLVSYSKCVQADLLCVWRRQPKNANNSHHSSSSGPGLGGSNRSPMNGANSMACPKELWLFWYGDEPSSLQSFISSDLFEVESGSWESGPLSYECRTLLFKAFHNLIERCLLAQNFARVGKWFVQPYNNTDQLNKDSAHLSMSFNFFLHGDSTVCVSVDVRRHEALFSLTHTVLSAAQHITVVLLAPYGLSGTLTGKIYSDSEARSMQMMEDWKKYVMVFIMEMCVDECEGDEGSQFFYCKYETGVRLRYPSNFVLMTSDVNAAVLKRMSTVSSSSANTSNVSNNNVGANNFCNNLATGALQQQQQVDSKRSLLLQWNYSAKVIEKSWRDLVVANGQVAHGQSQGSEDHALYNATNNIVWNFGDVTQRSNCHCPKSRTQKPALSSSKLSQPPSTSLMSSAPSSLTSLNKSSLGGFGGGSLSSWKQQQQASNNNNNSNNNYNSKAEGRVRAHKACTPYHKRHANFTHKLLSSTSSSLLTSSSLSLTTSTASSTISLLSQATLSQQLMSSLEANSFTLPMNFGWKNASSSSSMPASLLTSTSTAFGGSNRGGIVNVHNGSVMPGVDQQNNNNSQILPAVTQLSSSSATSSATATNVNSMASKSLLHQITSGLDSSPHSAAPSPLMVTPNAQGSTVNQNGSDPTMPTLSPQPPTKSGGSVEVGGRSILNSGRSITTGKDGHIGSVADGAVSDGVHNGNNDSNNGINVAGNVNYKKTVGGSSSGGLGSTTASNGSALATSILYTCSVDDYKSKYESLADSSVKSELLSRVRPADVGKTWIKQQNRKRSRSISQQNIVGTVPKKPMLMCQFPGEDDEEMKIPSLIVQPNFKLPNQGFICSATNPSNVSDQSFWTVVGEASGREDSLHTQHRHSNFSLIPGGSNSPFSGYQDDRYNNNNRDSVLPKIKKEDNQGSDFFGGMDDSRNAMDYSSSPITLSSSKNDFAATTAPGHNLPLQQQQQQQQQTQQQHQLGLSSSFTRQSTNVMPMSSIATLMRENDLKPNIQDLDKMFDTDEEIEPDSPNRPESIRDESMATAFKSTSLSTNFTQGKFLFNLMTFATFLFVYCYCLTVKDLSRMFPTPPSADNPCSEPSPMMEIDSHHDYGQQQQHCQQQQQQHSQQQQLLHQQLLLQHSTSSASFSPLINSSMANVSQSLINLRKECSSLYKIPLISRIPMSADYNPIQLPNTLSIPLNASNLVYKSSAPQPAVSSSSSTSLQPPFSSLIPSSSSFAYRQQQQQHQQLQHQQQQQRMNIGGMTGVIGGKVVGAGFMINNGRTPLSYDMLSPASNSSINRRPAGSVDSRVASSLEPINSLMVNVMISDSVLNLFKDHNFDSCTLCACNRNIDGSDIGIYARTSSDALVPSVLSSIEGIYGLKSGLFYEDEVEISGYYHTGLDNIRKPPLIKRHSSNNNNNNMNNNNNNNNSNNTNNVNNNNSNVGNSEENALSDDGITADIISIIREQFSTQFPTMPIQNLFKSEYSRFISRSNCGSGSNSGSNCGSSSGGCGDGKNKSVVGGVSVEEPVDLEMKDCSDACFLALEYCKFLSMENNNNSSSNNNNNNVGGGCNSQLSSSSSLLVDRSKVCLHEWSFRHELAPLPSSSLEVVRLLKQLQPLLQDAIQKKRSTRLWESVYTISGPLTWKDFHLLAGRGSKETSEPKSIPYLMVGYDKELLNISPHSIKYWDKLMLEPLCEPRDVLYLVVSPENDVVIDQVSNFFNDFSIMYEQCRLGKHRVLYDKLRDGIIRVGRKNEEPLRDVVIDDWYNNIDNIIVKNLNEKRQVYRDAAKIHSASGGSRFTISNPDQPPFTLYSTSTSSSSSLPNVMNLPPVPQHSFSQTISNPLAGINSNPNNNNNNNNNNGPVDSSMSGVFGGEKMDFSMNAGSNNLNSMSNNDNDGTNSSHQLQDGSGGGGYGSDFLHNNNLSHEVVVAGQMPYVVVYIVDSFNYTSPSNNTNNGSNDDDDDGSFSARMVMMSLLRGFNNMVKMMPEKLQPYVKLQIVPQDMIMDSCQRQTTSYMKNLCFSVYTSCRRQLSHHNMEKSLTGFGPTSSANKIIKKLNSTYQQLQHQGVISNNGAGAGGAGTNGGPGSGSLLGNVSANSVVSFGNNNGLITSAGNVIIINSTIASTLLYSPPFILAPPLFQSTSILSPENYKEPLEKCGVLLCAYCLSEDQRFLLASLVDSTGELLETTCINIDIGDRKVRRRATVRRFAFHKLWEFILGTVACTARPWRLVVGRFGRLGHGELKGWSMILSKRNLQSSCLMLRRICQTCNIPSANQCPSILSACLVSTEIHPSIHIMVDAVKKEENQSSKRQLSTPKDASCTHILVYPTSATAQATDPNSASDTHMDFTATELLNEEELLNGFDPEDPDMINDFWTNLDNSPERIIDDENHDDPSSIQSRGTFLGGSNIEHEENNNLNLLQQPQAMGFYVSTAPPGPLPDWFWSSCPQRHDHCPVCLKASLHLHCPMVQQNQDDLIHQSSNHKKSTHPLDSYLTCDVLRYVLETYNALSWLTIDPSTNDRRTCLPVHMLILMQLYHAVKAYL
Length2578
PositionMiddle
OrganismHelobdella robusta (Californian leech)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Clitellata> Hirudinea> Rhynchobdellida> Glossiphoniidae> Helobdella.
Aromaticity0.07
Grand average of hydropathy-0.469
Instability index53.28
Isoelectric point6.19
Molecular weight282166.32
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32685
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     508.83|     139|     145|    1328|    1468|       1
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 1328- 1447 (179.52/96.32)	...................................NSSIN....RRPAGSVDSRVASSLEPINSL.MVNVMISD................SVLNLFKDH..NFDSCTLCACNRNIDGSDIGIYA.RTSS....DALVPSVLSSIEGiYgLKSGLFYEDE.VEI.....SGYYHTGLDNIRKPPLIKRHS
 1448- 1585 (154.21/75.64)	SNNNNNNMNNNNNNNNSNNTN...........nvnNN..............NSNVGNSEE..NAL.SDDGITADiisiireqfstqfptmPIQNLFKSEysRFISRSNCGSGSN.SGSNCG.....SSSggcgDGKNKSVV....G......GVSVEEP.VDLemkdcSDACFLALE......YCKFLS
 1586- 1729 (175.11/87.03)	MENNNNSSSNNNNNNVGGGCNsqlsssssllvdrsKVCLHewsfRHELAPLPS...SSLEVVRLLkQLQPLLQD................AIQKKRSTR..LWES..VYTISGPLTWKDFHLLAgRGSK....ETSEP...KSIP..Y.LMVG..YDKElLNI.....SPHSIKYWDKLMLEPL.....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     250.91|      48|      56|     516|     563|       2
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  439-  483 (51.54/19.96)	...ST...SLMSSAPSSL.TSLNKSSL....GGFGGGS..LSswkqQQQASNNNNNS...N
  516-  563 (74.99/32.70)	SSTSS...SLLTSSSLSLTTSTASSTI....SLLSQAT..LS....QQLMSSLEANSFTLP
  572-  621 (66.03/27.83)	SSSSSmpaSLLTSTSTAFGGSNRGGIV....NVHNGSV..MP....GVDQQN.NNNSQILP
  624-  657 (27.47/ 6.90)	TQLSS...SSATSSATATNVNSMASK.....SLLHQITsgLD...................
  659-  694 (30.89/ 8.75)	.SPHS...A..APSPLMVTPNAQGSTVnqngSDPTMPT..LS....PQ.............
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     277.58|      64|     150|     969|    1032|       3
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  969- 1030 (100.63/56.50)	....................................................DY........................SSSP...ITL.SSS...KNDFAATTAPGHNLPLQQQQQQQQQTQQQ...HQL...GLSSSF..TRQSTNVMPMSS
 1031- 1088 (51.50/24.72)	IA......................................................................................tLMR...ENDLKPNIQDLDKMFDTDEEIEPDSPNRP...ESIrdeSMATAFksTSLSTNFTQ...
 1105- 1186 (68.97/36.02)	.....................................................YcycltvkdlsrmfptppsadnpcsEPSP...MME.IDS...HHDY......GQQQQHCQQQQQQHSQQQQllhQQL...LLQHST..SSASFSPLINSS
 1187- 1298 (56.47/27.93)	MAnvsqslinlrkecsslykiplisripmsadynpiqlpntlsiplnasnlvYK........................SSAPqpaVSS.SSStslQPPFSSLIPSSSSFAYRQQQQQHQQLQHQ...QQ.............QQRMNIGGMTG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     403.44|     105|    1516|     760|     963|       4
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  856-  963 (175.24/172.34)	DDEEMKIPSLIVQpNFKLPNQGFICSATNPSNVSDQSFWTVVGEASGREDSLHTQHRHSNFSLIPGGSNSP..............FSGYQDDRYNNNNRDSVLPKIkkEDNQGSDFFGG..MDD
 1798- 1914 (159.03/51.28)	DDWYNNIDNIIVK.NLNEKRQVYRDAAKIHSASGGSRF..TISNPDQPPFTLYSTSTSSSSSL.PNVMNLPpvpqhsfsqtisnpLAGINSNPNNNNNNNNNNGPV...DSSMSGVFGGekMDF
 2410- 2465 (69.17/ 7.49)	.....................................FWTNLDNSPER...IIDDENHDDPSSIQ..SRGT..............FLGGSNIEHEENNNLNLL.....QQPQAMGFY.......
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.75|      39|    1091|    1196|    1235|       5
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 1196- 1235 (64.77/43.53)	NLRKECSSLYKIPLISRIPmSADYNPIQLPNTL.SIPLNAS
 2290- 2329 (68.98/41.75)	NLQSSCLMLRRICQTCNIP.SANQCPSILSACLvSTEIHPS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     257.38|     116|    1412|     706|     852|       6
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  696-  777 (62.77/66.53)	...........................................................PTKSGGSVEVGG..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................rsilnsgrsittgkdghiGSVADGAVSDGVHNgNNDSNNgINVAGNVNYKKT.VGGSSSGGLGSTTASNGS
  787-  854 (85.48/47.79)	CSVDDYKSKYESLADSSvkSELL.SRVRPADVGKTWIKQQNRKRSRSISQ..QNIVGTVPKKPMLMCQFPG.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1943- 1993 (57.96/17.35)	.......................................................................eddeemkipslivqpnfklpnqgficsatnpsnvsdqsfwtvvgeasgredslhtqhrhsnfslipggsnspfsgyqddrynnnnrdsvlpkikkednqgsdffggmddsrnamdyssspitlssskndfaattapghnlplqqqqqqqqqtqqqhqlglsssftrqstnvmpmssiatlmrendlkpniqdldkmfdtdeeiepdspnrpesirdesmatafkstslstnftqgkflfnlmtfatflfvycycltvkdlsrmfptppsadnpcsepspmmeidshhdygqqqqhcqqqqqqhsqqqqllhqqlllqhstssasfsplinssmanvsqslinlrkecsslykiplisripmsadynpiqlpntlsiplnasnlvykssapqpavssssstslqppfsslipssssfayrqqqqqhqqlqhqqqqqrmniggmtgviggkvvgagfminngrtplsydmlspasnssinrrpagsvdsrvasslepinslmvnvmisdsvlnlfkdhnfdsctlcacnrnidgsdigiyartssdalvpsvlssiegiyglksglfyedeveisgyyhtgldnirkpplikrhssnnnnnnmnnnnnnnnsnntnnvnnnnsnvgnseenalsddgitadiisiireqfstqfptmpiqnlfkseysrfisrsncgsgsnsgsncgsssggcgdgknksvvggvsveepvdlemkdcsdacflaleyckflsmennnnsssnnnnnnvgggcnsqlsssssllvdrskvclhewsfrhelaplpssslevvrllkqlqpllqdaiqkkrstrlwesvytisgpltwkdfhllagrgsketsepksipylmvgydkellnisphsikywdklmleplceprdvlylvvspendvvidqvsnffndfsimyeqcrlgkhrvlydklrdgiirvgrkneeplrdvviddwynnidniivknlnekrqvyrdaakihsasggsrftisnpdqppftlyststssssslpnvmnlppvpqhsfsqtisnplaginsnpnnnnnnnnnngpvdssmsgvfggekmdfsmnagsnnlnsmsnndndgtnsshqlqdGSGGGGYGSDFLHN.NNLSHE.VVVAGQMPYVVVyIVDSFNYTSPSNNTNNGS
 2201- 2257 (51.16/13.24)	CLSEDQRFLLASLVDST..GELLeTTCINIDIGDRKVRRRATVRRFAFHKlwEFILGTV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.40|      28|     802|    1299|    1327|       8
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 1299- 1327 (47.08/29.79)	VIGGKVVGAGFMINNGrTPLSYDMLSPAS
 2104- 2131 (50.32/27.63)	VISNNGAGAGGAGTNG.GPGSGSLLGNVS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32685 with Med13 domain of Kingdom Metazoa
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