<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32684

Description Uncharacterized protein
SequenceMAAALAKYDPDKMQLDMLMEKLRNKNRRQKTAIESIKIFHGLSNAIPKASYTLDRLESIIMKFGLKYNVDNVRCELTVLADVFHIRMSVNSIGEVDDVTITMNGEPKPCFDLIKNFKAQKYDQLSEHISKLIAINDISNDNSIPSIQSYVHRSPLGILVPRTGGIPMKLIYFVGPYDLLNEKNKTMIPMTLEAFSPLNNSNSCMLPARFVVTLKEPMVVSWSLANKIQLLTVKPHSYNNITDINITTSIASLMSSYKVMPNKNKFLCLENPLNQNFLACVVDKIPFTHPTHLPNIVAQLRQQVLFNTLICSCVKSRNVLKSSSMKEFTDKDVQFEVTSLGLQLITATFQHPCKDSLLTIELELNDSISVTCKISSDNNNNNSVNNNNNNNNNNNNNDVIADGMPLIPCDYITRVMQRSLCLPIVLRALFKKVSANSMAMMMMMKQPSSSSSSSSSLAAYTSLPPTISLITNQNSFPNFDKSGADYFSRRNRGLPPPRQFNLPPLVYRKCRKAYSFLPEDSIDGKLLLKGTVAEVTGKVSFKSEFKQGGNFGPGNNNNNNNINNNNNNNNNNNGIFNNMYNNLGNNMNNNNFGANLCLADGANMNNNNMNNNNFINNVSMNSNNNNNNNNNMNNNNINNNNANFFNKNLNNNNVASVTNDNNNNNNNNFMNINNNNNMSNNNMNNNNNMNNNNNNKMAMRSPIKISVSKALANCIPSFNSKTQQMESVVVGLKNVGATNRQQQHMNNSRGMNAAMNAGKHAQQQIGMSVDFKQQQLQLTQQILQQQQQKRGENMKQQQQQLQQQHDNDVEIIDSPTSSASDNNSSGNNYRQTTTSSQQQQQHRIDKVSSNPMLASLLDQSSASSSSSLIGVGLPNISGMGVIAGMGQQGGKQQRKRPPSSDWSGAGRGNVSSNSNMNVNNTKRAKLSHNSISVDDYFNTQQQQQQQQQHLQQQQMVNTAGRSSLSSALDVAKNVASGGKMNDSGNNPILMNRQLSDPSNFQNYSQQQQQHMLQQQQQQMTSTSSAQWANASSSSSSSNNNNNARSNMHDKDQTMFNAANFKQQQQQQLFQQQQQQQQIIRPQQIIVKDQQQIRNNNNNNIDDTDWEVKIESSNIENNNSNSFNNNNNTFNSNKPPIRVKLDKRSFNTIPSNVNNNALQQVNNVSNSANVSNNINYNVNKNNLNNNNNVIGSNNNVVNNNNNNSNEGRKAFGSSLSDLLLDENNQSNSVDSDVGIIASITASPSYAQSSSSSAAATAAAATTTLSSSAPSSSLTSSFGKAVMPSSSSSSLGQSSSLSTLMTSSSSTKLLQQQQQQQQALKRLKSTATTINNSNNANINTKNSSSSNESKKMKRPYSSALSSSLVPTVSLGILSEDIARQKMSKKQKIYEFDDEECIMTASTSPNSSSSSSASSSSSMMPPIKITSAGGKLKIQNPSSKIKQIPGSASALIGRPGAHLHQVNAAHGLMAANQKSPKVFGVQGHQRLGKSGVGSRPKSAEAKRFDQKMMVKVAQNQFNNNNNNNNNNNNNNNVSNNNNNQQLMSSMSGSNNTNNSMNNNNMVNQSNQQPLQNNNNKFKPPQCTTPLSFQASTPSPKTTPTSSSSSSSSSSGNNNVSGMGKVGQLQQLQQQQNVATAGKSKSLSASGVSAGGTVGSAEGKSGNKKAGSLSLVIDSLMKKQHSVSSSDGSKSADSAVVQKEIYDAIRLEIIKEGNKPSTPTRDQLASSSSSSSSSASASSASASSMMMNSKMLQKKMNAANSISCSSGSSDGSNNNNNNNNNNNNNNNNNNNMASRTTPTSLSSSSSSSNNQFQPINAKGVSVNNNNNNNNNNNNVGNNNNNNNNNNRQAGGMNISKSPSPNSCSNNNNNSNNNNNNNNNVNNTNNNNNNNNSNNSAFAGTMLPLLTSSSSSSSSANANVVATANRPPQQQQNNNNNVSMGNNVNNNNNNNNNSNNANNNNNVCINLNNNPSVSLGRLNVKIPSSSSSLSSSSSLSALPLINNTMMRNNNNSSNKNNSNNNNETLEIKLLKTSQPPHQSQQQQPLLPLPILPLTNQANNNNNNIRMLHIQNNNNNNNNRSCAGSGGGILPVPTEYGGYQDKPLIKIPQQLQQQQQQQPIIYSNNNSINNNNSYDKSGKSMKVNDQQPNSRHFLDAVGTVDNSSNNNNSNNNNNGSSGVDNVGSVLSQQPTNNNNSNANNSAATVERMLAPPRSPSPVKMTSSPKNPLLTQSLSSASSPTSPKSIVIDLPKIIPEARNTSYSSKILSNSSVNTNKTAGSVVVVVDGVGGSGGATPGNDADVGITSADLTANNSSLLKNIQQQKSHSSFKSNESSGSGASRIYKSTTIDDDDDVILSDDKTDFPDNDLIIDVSPTSASSSSVFISDVAGSGSRNSTTTSTLLTTTPSTIIVLTDCGNVTSAAQQHNNNNNNNNKSNNNNNLNSATSSSSSSSFLLDLTISPPLPSSSSSSSSSTVLTGMAQNPAASAVVAATASTSSQLQQQQKPQSSPDGSVVCELDDDLMNEALIM
Length2520
PositionMiddle
OrganismHelobdella robusta (Californian leech)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Annelida> Clitellata> Hirudinea> Rhynchobdellida> Glossiphoniidae> Helobdella.
Aromaticity0.03
Grand average of hydropathy-0.803
Instability index51.19
Isoelectric point9.50
Molecular weight271745.78
Publications
PubMed=23254933

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32684
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     661.34|      55|      55|     584|     638|       1
---------------------------------------------------------------------------
  360-  401 (62.40/ 9.78)	...................ELE.LNDS...ISVTCKISSDNN........NNNSV..NNN.NNNNNN...NN.NNDVIAD
  533-  581 (64.63/10.44)	EVT....GKV.....SFKSE...FKQG...GNFGPGNNNNNNN......INN.....NNN.NNNNNNgifNNMYNN....
  584-  638 (111.32/24.24)	NNM....NNN.....NFGANLC.LADG...ANMNNNNMNNNNF......INNVSM..NSN.NNNNNN...NNMNNNNINN
  646-  684 (71.21/12.38)	KNL....NNN.....N.......VASV...TNDNNNN.NNNNF...........M..NI.....NNN...NNMSNNNMNN
 1754- 1784 (52.91/ 6.97)	........................ANS...ISCSSGSSD..............GS..NNN.NNNNNN...NN.NNNN.NN
 1785- 1837 (79.62/14.87)	NNM....ASR.....TTPTS...LSSS...SSSSNNQFQPINA.......KGVSV..NNNnNNNNNN...NNVGNNNNNN
 1838- 1894 (89.27/17.72)	NN.....NNRqaggmNISKSPS.PNSC...SN.NNNNSNNNNN.......NNNNV..NNT.NNNNNN...NNSNNSAFAG
 1895- 1955 (70.17/12.07)	TMLplltSSS.....S.SSSSA.NANVvatANRPPQQ.QQNNN.......NNVSMgnNVN.NNNNNN...NNSNNANNNN
 1959- 2016 (59.81/ 9.01)	INL....NNN.....P.SVSLGrLNVK...IPSSSSSLSSSSSlsalplINNTMM..RNN.NNSSNK...NNSNNNN...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     242.11|      54|      55|     964|    1017|       2
---------------------------------------------------------------------------
  774-  828 (45.58/ 6.54)	QLQLTQQILQQQQ........QK........rGENMKQQQQQLQQQHDN.DVEiiDSP...TSSAS..DnnsSGN....NY
  882-  941 (46.91/ 7.00)	AGMGQ....QGGK........QQrkrppssdwSGA..GRGNVSSNSNMNvNNT..KRAKLSHNSISvdD...YFNTQ..QQ
  942- 1002 (76.16/16.97)	QQQQQQH.LQQQQmvntagrsSL.........SSALDVAKNVASGGKMN.DSG..NNPILMNRQLS..D...PSNFQ..NY
 1003- 1059 (73.46/16.05)	SQQQQQHMLQQQQ........QQ.....mtstSSA.QWANASSSSSSSN.N....NNNARSNMHDK..D...QTMFNaaNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     328.07|      52|      52|    1586|    1637|       3
---------------------------------------------------------------------------
 1278- 1343 (46.40/ 8.28)	AVMPS......................SSSSSLG..QSSSLSTLMTSSSSTKLLQQQQQQ..QqalkrlkstattinnsnnaNINTKNSSSS
 1479- 1528 (58.47/13.15)	GHQRL.........GKS........GVGSRPKSA..EAKRFDQKM..MVKVAQNQFNNNN..N...................NNNNNNNNNN
 1529- 1575 (52.23/10.63)	VSNNN.........NNQ........QLMSSMSGSnnTNNSMNNN..NM.....VNQSNQQplQ...................N..NNNKFKP
 1586- 1637 (82.11/22.68)	ASTPS.........PKT........TPTSSSSSS..SSSSGNNNVSGMGKVGQLQQLQQQ..Q...................NVATAGKSKS
 2039- 2074 (45.37/ 7.87)	....L.........LPL........PIL..PLTN..QANNNNNNI....RMLHI........Q...................NNNNNNNNRS
 2131- 2194 (43.48/ 7.11)	....GksmkvndqqPNSrhfldavgTVDNSSNNN..NSNNNNNGSSGVDNVGSVLS.QQP..T...................NNNNSNANNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     251.11|      53|      53|    1079|    1131|       4
---------------------------------------------------------------------------
 1079- 1129 (85.04/28.48)	..RP..................QQIIVK.DQQQ...IRNN.NNNNIDDTDWEVKIES...SNIENN.....NSNSFNNNNNTFN
 1130- 1189 (60.57/17.57)	SNKP..................P.IRVKlDKRSfntIPSNvNNNALQQVN.NVS.NS...ANVSNNinynvNKNNLNNNNNVIG
 2231- 2271 (57.98/16.41)	SPTS..................PKSIVI.DLPK...IIPE.ARNTSY.........S...SKIL........SNSSVNTNKTAG
 2323- 2394 (47.52/11.74)	SNESsgsgasriyksttiddddDVILSD.DKTD...FP.D.NDLIIDVSPTSASSSSvfiSDVAGS.....GSRNSTT.TSTLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.64|      17|      19|    2433|    2449|       5
---------------------------------------------------------------------------
 1247- 1263 (22.32/ 8.36)	SSSSAAATAA.....AATTTLS
 2440- 2461 (22.32/ 8.36)	SSSSSFLLDLtisppLPSSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.91|      31|      53|    1354|    1384|       6
---------------------------------------------------------------------------
 1346- 1379 (41.01/27.43)	SKKMK....................rpySSALSSSLVPTVSLGILSEDIARQKM
 1380- 1433 (36.18/22.93)	SKKQKiyefddeecimtastspnsssssSASSSSSMMPPIKITSAGGKLKIQNP
 1434- 1465 (41.71/28.09)	SSKIK......................qIPGSASALIGRPGAHLHQVNAAHGLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.54|      21|      59|     173|     201|       7
---------------------------------------------------------------------------
  121-  141 (36.27/11.26)	YDQLSEHISKLI.....AINDISNDN
  176-  201 (31.26/23.10)	YDLLNEKNKTMIpmtleAFSPLNNSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.96|      14|      55|     685|     698|       9
---------------------------------------------------------------------------
  685-  698 (25.32/10.38)	NNNMNNNNNNKMAM
  711-  724 (22.64/ 8.07)	ANCIPSFNSKTQQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.90|      12|      19|     733|     744|      15
---------------------------------------------------------------------------
  733-  744 (22.59/11.58)	NVGATNRQQQHM
  755-  766 (22.31/11.35)	NAGKHAQQQIGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.08|      25|    1269|     836|     864|      18
---------------------------------------------------------------------------
  836-  864 (35.18/26.66)	QQQQQHRIdkVSSNPmlASLLDQSSASSS
 2106- 2130 (47.90/23.69)	QQQQQQPI..IYSNN..NSINNNNSYDKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.60|      27|     179|    2290|    2320|      25
---------------------------------------------------------------------------
 2290- 2320 (37.67/38.76)	NDADVGITSAdlTANNSSLLKniQQQKSHSS
 2474- 2500 (46.93/31.94)	NPAASAVVAA..TASTSSQLQ..QQQKPQSS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32684 with Med1 domain of Kingdom Metazoa
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