<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32671

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEGLPAVEPVELRDLVARCVDKSYENFRGLAHGLGGVAKAEERREQALKHLADTRSLFEKLLVLTRWSVQSPLAAQCAELLKTAKLFTDQLNESNDRLFFLHADLNRAKERTYDLATAIDVLYGGTYPRLPKLISYAMHPKEMPDVDEDKAIQEMDDIIRFRLIEEEIPSTFTRIDVDGGFVIAHVEGEFEIVFTLNGKESDSLWRLVAINTVLTDATATEKYKTLASTNTLRIIKANAPTELHYMHMRNLVQKCMNKSNAPFVAACDIMRDFCCSLSLQILVAQGHLLTDSRWKSSNVEFVYHADKQVLDICYWSSFCRPAVLTTEAAQLAAEMADKFKKPESESLPPYPTASLCVRLYSDPKHHDLLSLSLHPPPAPELRASLSDALVVPRNMYGLSAEAFLMGAMRMHVASALFCLERHLVLGTGTSTPLHLTTSEAVHIVRTERSVHIARADSGGLAQYQLELSFDVRTGLFTAACVAASKSPLVDGVVRALEALLQRSVKAQLGPTGFSLAIDDLKAVADAVSACLREMLAYEISEVASSFANIEVHRHVSVNWDRYIAFRRQQGNNVDALSISPNALFFQIVRNKESCGYLVVEIDREAEYESSTDVHYVENADDWIRVPAFSLLQLSSSAGAPSAVQFFQRFPAFRKDALAPMMPPPTKKQKTAASTPPLAPLFLHVVSLCHERIQLQHYVNFAKRRRVRIRYAGQGGTASSSHQSGEQIVSFPFPERVSSAPMEIRAVHGHLRKCGGFEMCVQLASPPFKFLIPDDFFGTMHHGDHHALPNTNLIFRYPPTSKLQPDNPLETFIADLLMNVKPMCEFGVKLEKTLGSLGRYGPDVDVRDHFIVERADPFSIVLACRTSNPKRCVAAGSTPDDTITYRITVQFKPKGGFILTSSHRGEHPLLQFIQAALNVHNDSAQLLEALERTTIPLAILSSVVSSQVISAKCYRHDSAPRREGGGGSLGGKKGGGKGLRFGYKGKLPGEEKGYYAERTYGGDDRSFMPADLLLIPRSQNHIRLTYADRCGIDVFFMENETVTIKSAPCGARVPSCAVDGGLSVSHATFGERLRNLVFPEMASL
Length1083
PositionTail
OrganismSaprolegnia diclina (strain VS20)
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Saprolegniales> Saprolegniaceae> Saprolegnia.
Aromaticity0.08
Grand average of hydropathy-0.138
Instability index44.90
Isoelectric point6.86
Molecular weight119939.02
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32671
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     381.21|     125|     234|       6|     145|       2
---------------------------------------------------------------------------
    6-  145 (189.05/197.73)	AVEPVEL.....RDLVARCVDKSYENFRGLAHGLGGVAKAeerreQALKHLADTrslfEKLLVLTRW...SVQSPLAA..Q....C..AELLKTAKLFTD..QL.NESNDRlfFLHADLNRAKerTYDLATAIDVLYGGtyPRLPKLISYAMHPKEMPD
  237-  380 (192.16/154.49)	ANAPTELhymhmRNLVQKCMNKSNAPFVAACDIMRDFCCS.....LSLQILVAQ....GHLLTDSRWkssNVEFVYHAdkQvldiCywSSFCRPAVLTTEaaQLaAEMADK..FKKPESESLP..PYPTASLCVRLYSD..PKHHDLLSLSLHPPPAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.47|      45|      80|     614|     660|       3
---------------------------------------------------------------------------
  614-  660 (70.55/48.45)	HYVENAD.DWIRVpAFSLLQLSSSAGAPSAVQFFQrFPAFRKDALAPM
  696-  741 (75.92/43.20)	HYVNFAKrRRVRI.RYAGQGGTASSSHQSGEQIVS.FPFPERVSSAPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.14|      20|      96|     799|     819|       4
---------------------------------------------------------------------------
  799-  819 (30.96/25.58)	TSKLQPDNPLETFIADLLmNV
  899-  918 (36.18/24.31)	TSSHRGEHPLLQFIQAAL.NV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.46|      42|     160|     821|     871|       6
---------------------------------------------------------------------------
  821-  871 (68.61/58.04)	PMCEFGVKLEKTLGSLGR.YGPdvdvRDHFIVERADPFsivlaCRTSNPKRC
  987- 1029 (73.85/43.49)	PGEEKGYYAERTYGGDDRsFMP....ADLLLIPRSQNH.....IRLTYADRC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32671 with Med14 domain of Kingdom Oomycetes
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