<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32670

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMLDNAMNGGPMQVDQLDVDDLFGDGVGVGVGVGVSLSLQTARPPSKQLRQRIDELRTRGCCQGVAWSRSGAIASVSPDGRSLETRFLRSHPDNGEWGLSEPTKVELVSTNPSSPIVHLAWASTASPELAVIDATGRVSILTYSINLNRPFATRKWDHEPCDDLHAVVGCYWLALAPQSKQYYVCHGPAVKDGNQYRYESSFVHAYGPWHPNQSKSALLCVTANGNLKMFWAQNNNKIEETTLELESINSSDDLITHAALHSDKSSLWVVLATASKQLKVVRVGIHWGLPQSQSDNKPPPGSQPLNPTMQEKHVAISSWLPGGSKILPSTMDLTGQGWAPLVILTVRTYLPTPNTPYQETQSIIDKWEVINDQPQSLHPAFEQLGNRRNSTGSAPTPKPTSRLKKYDPVVINKAIIGVHSLQYGRVVCLAFSDGSVEYRDRFTLQEIYNEMNLERIMSLNQVGFTFQDDSPCLQAALSPTNCSLVKIQDDGKVKWTRLHYPLGDIGNSNQEAQYSAVLAGLTVAASTATFNSINYDDILAVARPYADKKRFTFDWMNEIVRMLKIPVDYSEDTHHDSLVRNSSLQMCLSILNHLGYKGMFQPRSFGSKFAMLALNARNVVILITIASNTPVNIREKLSPLDEHEVVDALSGCAKWSLDLLSWLTDSLFALLDDPQFLALLTLQRFSEMSAYLQSRSDVSLHLLLCSSTRGFLSAVCRRILHLEILSNRAIEFYERRAAISNANDPNAATSKNLHTVLYKAYQKMQRVTSSSLIKVQEFDRLLTVLNNDIRSAYQTSLAALANKNPAGAQGNPKAIEQQIKGAQFHCELNMLLASSPPPSFLQVLLKFFNTDLKNYRAQTDPSKLFFADFDLLEIDDDRRSLSARKARGQYIDAFKRVELVGPPVRGAKELEEAKTPQWRRCVRCAAIMEDASGSRPGFTFVLAQQRKCSCGGHWALLPRGALIS
Length966
PositionTail
OrganismColletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.08
Grand average of hydropathy-0.251
Instability index44.55
Isoelectric point8.15
Molecular weight107232.87
Publications
PubMed=23902260

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32670
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.51|      29|     253|      29|      57|       1
---------------------------------------------------------------------------
   29-   57 (49.38/26.02)	VGVGVGVGVSLSLQTARPP..SKQLRQRIDE
  283-  313 (51.13/27.18)	VRVGIHWGLPQSQSDNKPPpgSQPLNPTMQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.09|      35|     128|     438|     472|       2
---------------------------------------------------------------------------
  438-  472 (61.29/46.92)	VEYRDRFTLQEIYNEMNLERIMS.LNQVGFT..FQDDS
  569-  606 (53.80/40.19)	VDYSEDTHHDSLVRNSSLQMCLSiLNHLGYKgmFQPRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.02|      21|      95|     166|     186|       4
---------------------------------------------------------------------------
  166-  186 (40.46/25.83)	LHAVVGCYWLALAPQSKQYYV
  262-  282 (35.56/21.83)	LHSDKSSLWVVLATASKQLKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.48|      34|     254|     222|     255|       5
---------------------------------------------------------------------------
  222-  255 (59.01/38.44)	CVTAN...GNLKMFWAQNNNKIEETTLE..LESINSSDD
  474-  512 (50.48/31.86)	CLQAAlspTNCSLVKIQDDGKVKWTRLHypLGDIGNSNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.14|      34|      95|     811|     846|       9
---------------------------------------------------------------------------
  811-  846 (53.44/44.73)	QGnPKAIEqQIKGAQF....HCELNMLLASSPPPSFLQVL
  907-  944 (56.70/37.33)	RG.AKELE.EAKTPQWrrcvRCAAIMEDASGSRPGFTFVL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32670 with Med16 domain of Kingdom Fungi
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