<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32668

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASGSSMPFSSLQPTPTGGRKPKNLAEFIARVQTERGFRNVTEESLKQEIEDRKNGVADVKEEEDTAMADGNEDEEEPADANAARNEVLRNIDAANNSALMALDFISLLLSKENPAQAGTTLSAQLRDWVGIGSLGIAKREDNDEQKQRDAEKAKDNRDVSLGWALIDINTTKESADKAASHLSKEVEREEKYWGEILAVRQAGWSMCRLPAEKQTLGVRFGFSEASPEFRNSSLAPLRRGDDGSAMLQHGRVGAGCQRLGVTIGRSGKTTGRLAFGTSVPDTALLQDRVLEARNTIFAQELWHELHREAHSLASYGVRASHSAITFNPASGPSLTLELENLEDIANKAEDHPDNMLAEATHLSLHIFLSHAHRLNELQRLRPTPPHQRRNQTQNQYHLLRPIVAKILHDRAIEQVTRFSGDLTNVFRQAGVSAANFILNTPPYPTADLRNSSGGSSVRPSASQALANQITTAPADFQLELILNATCRLQIRGRTFLTPLTTTQFQVQLLPNAAEPPNPEPAPNTLQGSYPPSRDPYPSFSALKDYLTDAATHALTDWSMSLIPPPQAPSPSEPARPEWTKSIRGTAIRDIDTENREVRFDILEDADERPILNVGAAWRTADQKSKIQRWKWSPYGPAEPMQIPHIVNAVVQSSDLATSAA
Length661
PositionHead
OrganismColletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.06
Grand average of hydropathy-0.569
Instability index47.02
Isoelectric point5.69
Molecular weight72734.31
Publications
PubMed=23902260

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32668
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.89|      38|      57|     511|     550|       1
---------------------------------------------------------------------------
  511-  550 (66.57/40.39)	PNAAEPPNPEPA.P...NTLQGSypPSRDPYPSFSALK.DYLTDA
  564-  606 (54.32/26.56)	PPPQAPSPSEPArPewtKSIRGT..AIRDIDTENREVRfDILEDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.88|      28|      58|     195|     224|       2
---------------------------------------------------------------------------
  195-  224 (46.09/34.51)	GEILA.VRQAGWSMCRlpAEKQTLGVRFGFS
  251-  279 (44.79/26.87)	GRVGAgCQRLGVTIGR..SGKTTGRLAFGTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.08|      39|      57|     383|     423|       3
---------------------------------------------------------------------------
  383-  423 (63.38/41.96)	PTPPHQRRNQTQNQYhlLRPIVAKILHDRAIEQVTRFSGDL
  443-  481 (64.70/36.91)	PYPTADLRNSSGGSS..VRPSASQALANQITTAPADFQLEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.49|      17|      34|      75|      91|       4
---------------------------------------------------------------------------
   75-   91 (27.55/16.26)	EEEPADANAARNEVLRN
  112-  128 (25.94/14.88)	KENPAQAGTTLSAQLRD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32668 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GFRNVTEESLKQEIEDRKNGVADVKEEEDTAMADGNEDEEEPADANAARNEVLRN
2) WSMSLIPPPQAPSPSEPARPEWTKSIRGTAI
37
558
91
588










Molecular Recognition Features






MoRF SequenceStartStop




1) KIQRWKWSPYG
2) RKPKNLAEFIARV
626
20
636
32