<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32665

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVIRGVQRAALRQWNEFIAKSLATRLDPDKFESYVPFLQAKHPLPPSVVADLFLRPQPHNHESLDPRVPRFLQVLSDLNYIDTPSILEALYKYSTSRAHSREAAQASNGGNPASKTLRWASSYSAEEVMFYRLTKSVAQGTAITNTETGLAIAKIMASWIALFTDAATAFTVDVMGQLQNSQAREEMESARAAFVALLLGVCENHTVMKAFGSPEAKNTRKALSESLANFVPTIMQNAGPIATRLDMFRTSTLAAFEPDDEQKNTSNVEIEDLFDSSVALENFVISELPIVNSRAGLYIYLNAALVGRPLIDDMSIFNYLNNRYQGDVQTTTIDLILASFDVLANAVSRNEGNSAAPLLRSFLMNKLPLLIENLSKHMYPPLTAEFCITEALGRVDTNTFPTLSSMFDESRSNNPFTDSVREEFCWACCLHGLVRESSIEGLLGETPYQNLPAGGRYVKDNLVAECLADPERMQALIGELDGKDGNAGAVCQALTEVLGQLCRNKETMSLKLLCSQLAQRPLSLDVMLLFEKPATILHPLCDLLENWKYDEDQGEYQPVYEEFGSILLLVMAFAYRYNLSVSDLGIVSPDSFVSKLLGQGHQSQVFDELSEQQKGHLDGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFQNIVLAFSTGHLSEESLRGGVEYLVDTFLLPSLVVAITYLSNSLLIERPECQKAIVRVLKSVLEPTSISKEASDMLSSVMNIVAKPLEHSLRTYQRSDPKSQEIEPLLRSIKDSIPMSRRTGAADHVELEAWSGVQQHQHNHQNVGFANTLRQTLQSLVQWSIHPAIDRPPPTYTHRQILVALNILGAKRLLQLIYEDIRQHSEAGSGSIVYDVAANLVCAPDANDSPWANALNFMDNSGNMRAPIQKKLTMREVLKSDAENCKRLQKIDMNLTEIVVRLHRKVESQMVVAQAAAIQADTMLQNDLGLGLDGGTGSLDDAMAAATANVVTGDGMSVDNVSLDLGMAGEMGLGGPSNAGGGLDLGDNDLFSGLDTGDDFQWDNMDLS
Length1042
PositionTail
OrganismColletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.07
Grand average of hydropathy-0.130
Instability index43.43
Isoelectric point4.85
Molecular weight114518.60
Publications
PubMed=23902260

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32665
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.29|      63|     216|     228|     321|       1
---------------------------------------------------------------------------
  228-  292 (98.29/75.76)	ESLANFVPtIMQNAGPI.......ATRLDMfRTSTLAAFEPD....................DEQKNTSNVEIEDLFDSSVA.LENFVISELP
  554-  644 (91.99/61.62)	EDQGEYQP.VYEEFGSIlllvmafAYRYNL.SVSDLGIVSPDsfvskllgqghqsqvfdelsEQQKGHLDGWIHGLFDSEAGgLGDELMSSCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.47|      18|     322|      25|      47|       2
---------------------------------------------------------------------------
   25-   42 (33.92/32.35)	LATRLDPDKFESYVP....FLQ
   55-   76 (30.56/14.47)	LFLRPQPHNHESLDPrvprFLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.19|      15|      15|     679|     693|       5
---------------------------------------------------------------------------
  679-  693 (25.16/17.62)	YLVDTFLL..PSLVVAI
  695-  711 (22.03/14.41)	YLSNSLLIerPECQKAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.31|      16|      16|     743|     758|       6
---------------------------------------------------------------------------
  743-  758 (28.59/18.04)	LEHSLRTYQRSDPKSQ
  760-  775 (27.72/17.28)	IEPLLRSIKDSIPMSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.16|      33|     211|     304|     348|       7
---------------------------------------------------------------------------
  304-  348 (43.38/64.70)	LNAALVGRPL.IDDMSIFNylnnryqgdvQTTTIDLILAsfDVLAN
  516-  549 (55.79/42.28)	LCSQLAQRPLsLDVMLLFE..........KPATILHPLC..DLLEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.57|      40|      41|     955|     994|       8
---------------------------------------------------------------------------
  955-  994 (68.81/50.45)	DTMLQNDLGLGLDGGT.GSLDDAMAAATANVVTGDGMSVDN
  998- 1038 (69.76/51.27)	DLGMAGEMGLGGPSNAgGGLDLGDNDLFSGLDTGDDFQWDN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32665 with Med5 domain of Kingdom Fungi
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