<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32661

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLNNNISSIVFRVYEPSQEHAQTFPSAAADVETELRNRGHIVYYDATRRVLWYFHVPGKGAATTDDNNGALGNTIEVEGATLLMVEDGSFEPVSLFKGRAPGQQAANTPTSSSSSNSALDLSLRNSQNTGSGPPSSSDPDSKPASAGGPDAKGTGSVPLKDAYEHFVTALLSTVSAAFCSRICAIPVNYRTVLFPAKVSRENQSDRALDSDSAVVGTFRIYLTTTGALVMSLSLSCCEGLLSVNEPSSPGQIVLGSQILAAPFGVLANYQGFMGGGLSYPELGLGQTPDTQLWRSADAKSSQWRDTCIKILQSRGLSPTLFQSCPWIALQMIRRKPGDGKSTPLPSTMATISWPAALCFRKKSVILARNHGLGDTALLAHEETADFLSEARTWFQLGTDREEKVTKRKKEREIAATKETPAAVPPQQPNGHSPLGLRRASNAAAVGAMYPTPPDGVQNPLGITPSIDGTTSSPGAPNATVAIVDIDTAMADVTMPETAVPHASQHHESYGDGGWNPNDNKPRADSFLGGESDNLFGDMGPDMFGDADITDADFSFFDEQPGDDLDLSGLPDMGMSDAPSMAPVLPPPLPEPAKMAAPPIEYTKPEPSPPIFTKPELKHARSTLMDEGKQRPSTEKAAGVKRESSPFGPDTVYKRVRASLGDIDSAPSKTPSRKGSVFDSVGFDSVLPSVNKKYEQGGRFDCNPVTRGLAQEPITEPGAQGPPTTDYLRRHGKQRKQLKHSEQTSVVIRTITGGLENATLNTSPAKMDDFASDADDVSLVSDQDDASSTTDEPASPFKSSIRRLNFDDDVVSHVTSLKDIESVEDSDPTLALELPKLAKVEATEVSITKYFEDSEALPIHLSLTDEDMVTIAQIVTEQAVTGNLKIRDSQANTLNTAIISETRRQLSSLSRTALQTLREVVPACLGEFNTCNFKGVVEVPDVPLLGQPNRLHPRPVPQRDSNAEPPKPNNLFQIPAPHMELRRAEARLSVLPSSVQFWESLGLGPAQGTKNVNVVCVFPNWDGMTDVAAAFLDRMRNVYELLKLGSFERLPTSSKVTDGLMPFEADKIATSPGTVSPHIGSSLDDRMEALNQGLLSANVTEKNFVVYFVYPPDHPGSIVEECTAFQRLFEIHKRSLTDRRQAPVNELVLQLVPLDFLTSPVGIVEPTPSDAIKLAIETYDRCTLFGGPMPSPAIMLEQSLPRGIDFKISNTSSSSLMHENTCMHIAYAQSIDERWITAAWTDNRGCQQMTASYSLGRKGKPLSTSLNDVYHEIWDTTHDLISKWKVHWRVIVTKCGPMDQQEIGFWQGLAQTESMASVSLTLISVDTNPSLQLLPPAIKVPATASSAFYTTPVSTPQASILSPEQSGTPATPMKENNPVNAATPGGTPGDGNAEPAEGDAILLDVTDQTWGAVLAHRLSNSSTLGELNPAIISGYLVKRGGTKLEDPPVVLEVNILHVDSNPRMCETLMREMLTYFRGLGTLARARGIVDRGTDIRPWHIAAAEKGVRTLYLLM
Length1523
PositionKinase
OrganismColletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.06
Grand average of hydropathy-0.333
Instability index49.24
Isoelectric point5.10
Molecular weight164449.08
Publications
PubMed=23902260

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32661
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      13|      14|     680|     693|       1
---------------------------------------------------------------------------
  680-  693 (20.05/16.91)	PSRKGSvFDSVG.FD
  697-  710 (20.46/11.66)	PSVNKK.YEQGGrFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.99|      52|     312|     116|     168|       2
---------------------------------------------------------------------------
  116-  168 (87.16/40.09)	ANTPTSSSSSNSALDLSlRNSQNTGSGPPSSSDPDSKPASAG.GPDAKGTGSVP
  431-  483 (90.83/38.95)	AAVPPQQPNGHSPLGLR.RASNAAAVGAMYPTPPDGVQNPLGiTPSIDGTTSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.08|      16|     580|     611|     626|       3
---------------------------------------------------------------------------
  611-  626 (31.42/15.89)	YTKPEPSPPIFTKPEL
 1194- 1209 (30.66/15.31)	FGGPMPSPAIMLEQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.13|      26|     305|     760|     785|       4
---------------------------------------------------------------------------
  760-  785 (45.81/23.31)	ITGGL...ENATLNTSPAKMD.DFASDADD
 1065- 1094 (35.32/16.40)	VTDGLmpfEADKIATSPGTVSpHIGSSLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.72|      82|    1050|     298|     384|       6
---------------------------------------------------------------------------
  298-  384 (146.55/78.00)	PDTQLWRSA....DAKSSQWRDTCIKILQSRGLSP.......TLFQSCPWIALQMIRRKPGDGKSTPLPSTMATI.....SWPAALCFRkksviLARNHGLGD
 1338- 1435 (125.17/59.26)	PSLQLLPPAikvpATASSAFYTTPVSTPQASILSPeqsgtpaTPMKENNPVNAATPGGTPGDGNAEPAEGDAILLdvtdqTWGAVLAHR.....LSNSSTLGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.95|      29|     382|     569|     604|       8
---------------------------------------------------------------------------
  572-  603 (50.29/36.55)	DDL..DLSGLPDM.GMSDAPsmaPVLPPPLPEPAK
  817-  848 (39.66/11.36)	DDVvsHVTSLKDIeSVEDSD...PTLALELPKLAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.74|      17|      18|     928|     945|      16
---------------------------------------------------------------------------
  928-  945 (29.47/20.56)	EV..VPaCLGEFNTCNFKGV
  947-  965 (28.27/14.93)	EVpdVP.LLGQPNRLHPRPV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32661 with Med13 domain of Kingdom Fungi
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