Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKVIDARFERVEKALASLIESVSKYHPNAKQALDLHEADNDLARGLDEVQVHQNNHLRLQQLRATTTSLDSQIRETLQSLATTRKDITTTQITMYSNGPKYPVKYDELLNYARRISKTTMPPAAITNGVPTEGSTPAPDPNASMTAATTPGANGMQSQPVSAAPTPSQTQTPDASGGINGGTSSGDLAATQQTATSGATSLPDGLRNHLDPHFNASFIPWPNEFQIRSGAMAVFQELQDQGIEPRGYDPAQIAEAKRKEEEERKAREEQEKAELERKNREYQEKMERIRREQQEAYRRDSMAVGAGASSAGKNKQFQFTSIMDDDDDDE |
Length | 330 |
Position | Middle |
Organism | Colletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.910 |
Instability index | 49.95 |
Isoelectric point | 5.13 |
Molecular weight | 36392.62 |
Publications | PubMed=23902260 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32660 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 77.28| 21| 25| 138| 158| 1 --------------------------------------------------------------------------- 138- 158 (39.62/17.79) APDPNASMTAATTPGANGMQS 164- 184 (37.66/16.62) APTPSQTQTPDASGGINGGTS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.67| 18| 21| 254| 271| 2 --------------------------------------------------------------------------- 254- 271 (30.76/17.97) AEAKRK.....EEEERKAREEQE 273- 295 (25.91/14.22) AELERKnreyqEKMERIRREQQE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EAYRRDSMAVGA 2) KNKQFQFTSIMDD | 295 313 | 306 325 |
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