<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32653

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGQNGTHSNHDRNLKMNGINGTTMDGQPSPNKGKAPVEASNNLANGVPADPGKQQSQMNTGLTLQPKSRMNDLPEEIVHITQGYIPLSMIVSRLAQRTHEDLQKVIMEMAAVKWAPPAVNGNTPHGNEAPDDMSEGNKRKKMLMLKFAQDAHAKWVKALVITDWSRNAEAVSKLIDIKAHIDSKRMLYDYAQDLLIDLKRGLNGARLPNPDLKTALQVLTTGEASWVPEPGYIPPPPLTPEEQLKWIDDLNTMLSLRLNLDDYDKIPHQFKTYSIHSGRVTFKVKGEFEVDLTIADEDFTKQFWFIDFRFVFSPSAKKLSDGLVSFLEGQVNEILGKDGLEGCYRFLHEFVLTHKINELKRQALELSRSTWTGTLMVEPLNRALALQYWTTRYGPNGPKSWVMVAVNSAKKTNGQLDSKQSSRLVARWYRDNKEVKDVLLPFDVDTLCAEDLLKTAVARHVEHILSSIHSKLLSYPRFANRESSMTLKVSKREPVESFLSMQLSPRENVTLVVEPVTGFAAIQPHTKYTLSGETRLNYGQKDPAEDGVVCLESIRWGYVMEEFNRRGRSVGWKTCKSPLSNEDIKQLIRTREAFQTVFLQRQSLDEDWHVMASLSLAGDEWWLIQIDRNTPARPIKFSCRLRLNHGQPDLDDSFWSNLTTFVTGTISHVTDLQNLHTNRIKYVMRESTNYSLPQQVRMPSILLKLSQILRHSHLGGHSGANDASDESDKYAPSWAQNHVEIKFKGLQPQVPAALGKDDNGASPVDVIDNCKINTVVDAIIRVKDRSKFTLLKGRIDRDVSFSPRKGEFIFRIRQTVGHPILDILTSHVKSIDRLVGFLEAISKARGSLKCERMSLRQVIFTYGDVAMPGESDATAKPRRWRATLDLARSDIRMSLERGNPHLRMLDLFTTMVNTQAGLKALIIYMPLMLPVLKTVESIESKWEAPESTNQGRVEVFPRAVDWVAIRYTLTRPSGQSRVLSVDVRSKIRRHESWFHVQRVTGGESFGPDEEFNKILKGIWESHGDGWRGLTTAAASRPGPSIMDLLTKLDDAVRTHAATGGSGPPSSDGAATQFSQTFSANQSFGTQPTSVSQGSNRTSGSKQAPLVLD
Length1111
PositionTail
OrganismColletotrichum gloeosporioides (strain Cg-14) (Anthracnose fungus) (Glomerella cingulata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.07
Grand average of hydropathy-0.450
Instability index39.53
Isoelectric point8.97
Molecular weight124680.46
Publications
PubMed=23902260

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32653
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.13|      39|     146|     638|     683|       1
---------------------------------------------------------------------------
  487-  528 (54.30/28.78)	SMTLKVSKREP..VESFLSmQLSPreNVTLVVEPVTGFAAIQPH
  641-  681 (66.84/61.72)	SCRLRLNHGQPdlDDSFWS.NLTT..FVTGTISHVTDLQNLHTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     295.16|     106|     505|     228|     357|       2
---------------------------------------------------------------------------
  228-  357 (156.32/152.46)	SWVpepGYIPPPPLtpeeqlkwiddlNTMLSLRLNLDDYDkiPHQFKTY...SIHSGRvtfKVKGE..........................FEVDLTIADEDFTKQFWFIDFRFVFSP......SAKKLSDGLVSFLEGqVNEILGkdGLEgCYRF.LHEFVLTH
  373-  457 (59.39/30.55)	TWT...GTLMVEPL............NRALALQYWTTRYG..PNGPKSWvmvAVNSAK...KTNGQldskqssrlvarwyrdnkevkdvllpFDVD.TLCAEDLLK............................................................
  795-  865 (79.46/39.62)	...............................................................KGR..........................IDRDVSFSPR..KGEFIFRIRQTVGHPildiltSHVKSIDRLVGFLEA.ISKARG..SLK.CERMsLRQVIFTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.95|      18|     338|     702|     719|      10
---------------------------------------------------------------------------
  702-  719 (33.49/23.45)	PSI...LLKLSQILR.HSHLGG
 1042- 1063 (23.45/14.18)	PSImdlLTKLDDAVRtHAATGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.84|      12|     784|     145|     158|      12
---------------------------------------------------------------------------
  145-  156 (20.04/15.50)	MLMLKFAQDAHA
  162-  173 (19.80/ 6.22)	LVITDWSRNAEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32653 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MENGGQNGTHSNHDRNLKMNGINGTTMDGQPSPNKGKAPVEASNNLANGVPADPGKQQSQMNTGLTLQPKSRMNDLPEE
2) VRTHAATGGSGPPSSDGAATQFSQTFSANQSFGTQPTSVSQGSNRTSGSKQAPLVLD
1
1055
79
1111










Molecular Recognition Features






MoRF SequenceStartStop




NANANA