<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32652

Description RNA polymerase II holoenzyme cyclin-like subunit
SequenceMSGSFWTSTQRHHWQYTKASLAKERQKLWLLECQLFPQGLNIVMDSKQNGIEQSITKNIPITHRDLHYDKDYNLRIYCYFLIMKLGRRLNIRQYALATAHIYLSRFLIKASVREINLYMLVTTCVYLACKVEECPQYIRTLVSEARTLWPEFIPPDPTKVTEFEFYLLEELESYLIVHHPYQSLKQIVQVLKQPPFQITLSSDDLQNCWSLINDSYINDVHLLYPPHIIAVACLFITISIHGKPTKGSSLASAASEAIRDPKNSSSPVQIAFNRFMAESLVDLEEVMDTIQEQITLYDHWDKYHEQWIKFLLHTLYLRPASAI
Length323
PositionKinase
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Saccharomyces.
Aromaticity0.11
Grand average of hydropathy-0.140
Instability index57.93
Isoelectric point6.67
Molecular weight37790.21
Publications
PubMed=7877695
PubMed=7732022
PubMed=9169873
PubMed=24374639
PubMed=9702190
PubMed=11555651
PubMed=11226276
PubMed=12200444
PubMed=14555478
PubMed=12520306
PubMed=15477388
PubMed=16076843
PubMed=16109375
PubMed=15601835
PubMed=15687503
PubMed=16630888

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions. 
ECO:0000269	PubMed:11226276
ECO:0000269	PubMed:11555651
ECO:0000269	PubMed:12200444
ECO:0000269	PubMed:12520306
ECO:0000269	PubMed:15601835
ECO:0000269	PubMed:15687503
ECO:0000269	PubMed:16076843
ECO:0000269	PubMed:16109375
ECO:0000269	PubMed:16630888
ECO:0000269	PubMed:7877695
ECO:0000269	PubMed:9702190
GO - Cellular Component
mediator complex	GO:0016592	IDA:SGD
nucleus	GO:0005634	IBA:GO_Central
GO - Biological Function
cyclin-dependent protein serine/threonine kinase regulator activity	GO:0016538	IDA:SGD
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	IDA:SGD
GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IMSGD
positive regulation of transcription by galactose	GO:0000411	IMSGD
positive regulation of transcription by RNA polymerase II	GO:0045944	IDA:SGD
positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle	GO:0010673	IMSGD
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32652
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.05|      18|      23|      72|      94|       1
---------------------------------------------------------------------------
   75-   94 (30.15/28.09)	RIY.CYFLIMKLGRRLNIrqY
  100-  118 (27.90/11.40)	HIYlSRFLIKASVREINL..Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.27|      38|      94|     182|     224|       3
---------------------------------------------------------------------------
  182-  224 (61.94/47.22)	QSLKQIVQVLKQPPFQITlssddLQNCWSLINDSYIN.DVHLLY
  278-  316 (64.33/38.54)	ESLVDLEEVMDTIQEQIT.....LYDHWDKYHEQWIKfLLHTLY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32652 with CycC domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA