<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32634

Description Meiotic mRNA stability protein kinase SSN3
SequenceMYNGKDRAQNSYQPMYQRPMQVQGQQQAQSFVGKKNTIGSVHGKAPMLMANNDVFTIGPYRARKDRMRVSVLEKYEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKKPLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYFTESDIPVSENVFEGLTYKYPARRIHTNDNDIMNLGSRTKNNTQASGITAGAAANALGGLGVNRRILAAAAAAAAAVSGNNASDEPSRKKNRR
Length555
PositionKinase
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Saccharomyces.
Aromaticity0.09
Grand average of hydropathy-0.505
Instability index34.38
Isoelectric point9.59
Molecular weight62846.21
Publications
PubMed=8164691
PubMed=7877695
PubMed=9169875
PubMed=24374639
PubMed=9845373
PubMed=9702190
PubMed=10360183
PubMed=11331604
PubMed=11555651
PubMed=11226276
PubMed=12200444
PubMed=12520306
PubMed=15175151
PubMed=14749387
PubMed=15240822
PubMed=15477388
PubMed=14988503
PubMed=16076843
PubMed=16109375
PubMed=15601835
PubMed=15687503
PubMed=16630888

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II RPB1 at serines 2 and 5. The SSN3/SRB10 and SSN8/SRB11 kinase-cyclin pair may also positively and negatively regulate numerous transcriptional activators in response to changes in nutritional and physiological conditions. Phosphorylates GCN4, promoting its ubiquitin-mediated degradation, and MSN2, promoting its nuclear exclusion. Phosphorylates STE12, thereby promoting its degradation and inhibition of filamentous growth. Phosphorylates GAL4, and this phosphorylation is required for efficient galactose-inducible transcription. Also phosphorylates BDF1 and the TAF2 subunit of the TFIID complex. 
GO - Cellular Component
mediator complex	GO:0016592	IDA:SGD
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IDA:SGD
metal ion binding	GO:0046872	IEA:UniProtKB-KW
protein kinase activity	GO:0004672	HDA:SGD
protein serine kinase activity	GO:0106310	IEA:RHEA
protein threonine kinase activity	GO:0106311	IEA:RHEA
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IDA:SGD

GO - Biological Process
meiotic cell cycle	GO:0051321	IEA:UniProtKB-KW
negative regulation of filamentous growth	GO:0060258	IMSGD
negative regulation of transcription by RNA polymerase II	GO:0000122	IMSGD
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IMSGD
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IDA:SGD
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IMSGD
protein destabilization	GO:0031648	IMSGD
protein phosphorylation	GO:0006468	IMSGD
response to oxidative stress	GO:0006979	IMSGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32634
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.20|      39|      94|     207|     249|       2
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  207-  249 (63.69/58.26)	EMALCRELHNKhlttLVEIFLERKCVHMVYEYAEHDLLQIIHF
  304-  342 (68.51/51.27)	DLGLARKFHNM....LQTLYTGDKVVVTIWYRAPELLLGARHY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32634 with CDK8 domain of Kingdom Fungi
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