<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32632

Description Serine/threonine-protein kinase SSN3
SequenceMSDQIRASGYFYSQTDDPFAAAFWSQFQDPHVLAARHIPADSSASAAMKAYREYRDRVRKPVLATYTILGFLSSGTYGRVYKARLRTPPQLASSSGTAGIANANAGTGSGTATVGSGASTAKKRGGLLQQHQLLDSPSSSLHATPKSVADGAGVGVNGTPSASPSLSASLGTSTANAPGGSDNTLQLSSNELPDTQIYAIKKFKPDSKETDATIYTGISQSAMREISLNRELSHVNIVTLHQVMLEDKAIYMVFEYAEHDLLQIIHYHSTALRAPIPLAVLKSLLWQLINGVAYLHANWILHRDLKPANILVTSQGVVKIGDLGLARLYSSPLQSLYNGDKVVVTIWYRAPELLLGARHYTTAIDMWSVGCIWGELLALRPMFKGEEAKMDPKTKAAPFQTDQLKRIVEVLGTPNKDRWPAIESMPDYKGWWPHLRLDNYPKTLSRWYATRNKGDDGYELFNSLLQYDPEQRLTANQALEHAWFTAQDPKPTANAFSSLAKPHATYPNRRVIQDDMDPKMKSNYVPPIKSHHMQPWHQVNLNSSQPHRLAQLMYQQEQMRHQQMQTQAPAPAPAQPPAATAVTGRLGHAVGAGSSAVGTAANVGGPAAPPPIAIGSTAGTGGAIGIQSSAASTAPSQHMYNNNPLITIAGTNGGTISNPATVRSSHSIGSTESITPTTSSQPIPAQPSSAPLARTTNLVATATRNQQRKRQRN
Length713
PositionKinase
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Ustilago.
Aromaticity0.07
Grand average of hydropathy-0.381
Instability index46.16
Isoelectric point9.53
Molecular weight77022.97
Publications
PubMed=17080091

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-KW
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
metal ion binding	GO:0046872	IEA:UniProtKB-KW
protein serine kinase activity	GO:0106310	IEA:RHEA
protein threonine kinase activity	GO:0106311	IEA:RHEA
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central
GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32632
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.00|      19|      26|     577|     598|       1
---------------------------------------------------------------------------
  577-  598 (29.27/22.09)	PAA........TAVTgrlGHAVGAGSSAVG
  606-  632 (26.72/12.32)	PAApppiaigsTAGT...GGAIGIQSSAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     132.53|      24|      26|     488|     511|       2
---------------------------------------------------------------------------
  391-  407 (26.32/11.80)	DPKTKAA.......PFQTD..........QLKRI
  441-  473 (23.39/ 9.67)	.PKTLSRWYATRNKGDDGYelfnsllqydPEQRL
  488-  511 (41.80/23.04)	DPKPTANAFSSLAKPHATY..........PNRRV
  517-  539 (41.02/22.48)	DPKMKSNYVPPI.KSHHMQ..........PWHQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.90|      22|      25|     636|     660|       3
---------------------------------------------------------------------------
  636-  660 (31.97/25.91)	SQHMYNNNPLITiAGTNGGTIsnPA
  664-  685 (38.93/20.68)	SSHSIGSTESIT.PTTSSQPI..PA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.97|      13|      25|      52|      64|       4
---------------------------------------------------------------------------
   52-   64 (24.09/16.44)	REYRDRVRKPV.LA
   79-   92 (19.88/12.24)	RVYKARLRTPPqLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.01|      17|      25|     136|     157|       5
---------------------------------------------------------------------------
  136-  153 (26.32/20.60)	SPSSSlHATPKSVADGAG
  163-  179 (29.69/ 9.95)	SPSLS.ASLGTSTANAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.39|      13|      25|     343|     358|       6
---------------------------------------------------------------------------
  317-  327 (19.28/ 8.79)	VVKI....GDLGL.AR
  343-  358 (20.23/18.42)	VVTIWyraPELLLGAR
  369-  380 (23.88/12.44)	VGCIW...GE.LLALR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32632 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KPTANAFSSLAKPHATYPNRRVIQDDMDPKMKSNYVPPIKSHHMQPWHQVNLNSSQPHRLAQLMYQQEQMRHQQMQTQAPAPAPAQPPAATAVTGRLGHAVGAGSSAVGTAANVGGPAAPPPIAIGSTAGTGGAIGIQSSAASTAPSQHMYNNNPLITIAGTNGGTISNPATVRSSHSIGSTESITPTTSSQPIPAQPSSAPLARTTNLVATATRNQQRKRQRN
2) LASSSGTAGIANANAGTGSGTATVGSGASTAKKRGGLLQQHQLLDSPSSSLHATPKSVADGAGVGVNGTPSASPSLSASLGTSTANAPGGSDNTLQLS
490
91
713
188










Molecular Recognition Features






MoRF SequenceStartStop




1) IRASGYFY
2) QIYAIKKF
5
196
12
203