<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32631

Description Serine/threonine-protein kinase srb10
SequenceMKDGYKIIGFISSGTYGKVYKAVSSNSNDKRLFAIKKFKAESKQVSSNAQQTGVSQSAIREMMLCREIQHENIVSLVQVLLKDGTISMVFEYAEHDLLQIIHFHSRSRTRQIPPSILKSILWQIINGVAYLHENWIMHRDLKPANIMITATGKVKIGDLGLGRLIRDPILPFYSSDRVVVTIWYRAPELLLGAHDYTPAIDVWAIGCIYGEMLALSPLFKGDEIKMEDKKVVPFQSTQMLRIMELLGTPTEERWPGLKNYPEYYQLSSFEVRYWNNLLPQWYQTVKNRDPQGLDLLMKMLQYDPKSRITAKQALEHVFFTSDKLWTTSPFLNQPIHYPERRISEDDSEVSSKRVLSTSLRSESKRFKGN
Length369
PositionKinase
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.10
Grand average of hydropathy-0.324
Instability index48.39
Isoelectric point9.26
Molecular weight42584.72
Publications
PubMed=9559556
PubMed=11859360
PubMed=21511999
PubMed=12738880
PubMed=14534314
PubMed=17043218

Function

Annotated function Catalytic component of the Cdk8 module/Srb8-11 module which is a regulatory module of the Mediator complex that regulates basal RNA polymerase II transcription. The Cdk8 module may sterically hinder the interaction between Mediator and RNA polymerase II leading to transcriptional repression of a subset of genes regulated by Mediator. 
ECO:0000269	PubMed:14534314
GO - Cellular Component
euchromatin	GO:0000791	IDA:PomBase
mediator complex	GO:0016592	IPI:PomBase
nucleus	GO:0005634	IBA:GO_Central
F:transcription coactivator activity	GO:0003713	IPomBase
P:positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IPomBase
GO - Biological Function
ATP binding	GO:0005524	ISM:PomBase
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IDA:PomBase
metal ion binding	GO:0046872	IEA:UniProtKB-KW
protein serine kinase activity	GO:0106310	IEA:RHEA
protein threonine kinase activity	GO:0106311	IEA:RHEA
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central
transcription coactivator activity	GO:0003713	IC:PomBase
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IMPomBase
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IC:PomBase
protein phosphorylation	GO:0006468	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP32631
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.05|      43|      52|     152|     203|       1
---------------------------------------------------------------------------
  146-  199 (50.32/66.96)	IMITatGKVkIGD.LGLGRLIR.DPIlPFysSDRVVV....TIWYRAPElLLGahdyTPA
  200-  250 (59.73/41.34)	IDVWaiGCI.YGEmLALSPLFKgDEI.KM..EDKKVVpfqsTQMLRIME.LLG....TPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32631 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) DKRLFAIKKFKAE
2) KRFKGN
3) LNQPIHYPERRIS
4) MKDGYKIIGFISSGTYGKVYKAVS
29
364
331
1
41
369
343
24