Description | Serine/threonine-protein kinase SSN3 |
Sequence | MQNSGRDLWQNQSGYMSSLQQGLNKSNMVGASTSHGKTPMLMANNDVFTIAPYRTRKDNARVSVLDKYEIIGYIAAGTYGKVYKAKSRQSSKSSSSTGSDSLAQDTKPTTEFSNTSSLQNAGTYGDMMGAHGPNSNNISAGGNTNPELSTRNNPNNPRVPTSTIISGDKRNSENTDNRRKAETTMYYAIKKFKTEKDGIEQLHYTGISQSACREMALCRELDNNHLTKLVEIFLQKKSIYMVYEFAEHDLLQIIHFHSHPEKRMIPPRMIRSIMWQILDGVSYLHQNWVLHRDLKPANIMVTMDGVVKIGDLGLARKFSNMLQTMYTGDKVVVTIWYRAPELLLGARHYTPAIDLWAVGCIFAELIGLQPIFKGEEAKMDSKKTVPFQANQLQRILKILGTPTPKSWPHLQKYPEYEQLSKFPKYRDNLPGWFHSAGGRDKHALSLLYHLLNYNPIERIDAINALDHSYFTHGDMPVCENVFEGLNYKYPARRIHTNDNDILNLGLHKPKVPAKVVQPTMNNSTATLGGLGVNKRILAAAAAAAAAVSGNSSSQSSRNMEPMKKKRK |
Length | 567 |
Position | Kinase |
Organism | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Nakaseomyces> Nakaseomyces/Candida clade. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.538 |
Instability index | 43.50 |
Isoelectric point | 9.53 |
Molecular weight | 63531.73 |
Publications | PubMed=15229592 |
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex. The SRB8-11 complex
phosphorylates the C-terminal domain (CTD) of the largest subunit of
RNA polymerase II (By similarity).
ECO:0000250 |
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblFungi |
GO - Biological Function | ATP binding GO:0005524 IEA:UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity GO:0004693 IEA:UniProtKB-EC metal ion binding GO:0046872 IEA:UniProtKB-KW protein serine kinase activity GO:0106310 IEA:RHEA protein threonine kinase activity GO:0106311 IEA:RHEA RNA polymerase II CTD heptapeptide repeat kinase activity GO:0008353 IEA:UniProtKB-EC |
GO - Biological Process | negative regulation of filamentous growth GO:0060258 IEA:EnsemblFungi negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi nuclear-transcribed mRNA catabolic process, non-stop decay GO:0070481 IEA:EnsemblFungi phosphorylation of RNA polymerase II C-terminal domain GO:0070816 IEA:EnsemblFungi positive regulation of transcription from RNA polymerase II promoter by galactose GO:0000435 IEA:EnsemblFungi protein destabilization GO:0031648 IEA:EnsemblFungi response to oxidative stress GO:0006979 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP32620 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 152.77| 47| 345| 7| 175| 1 --------------------------------------------------------------------------- 123- 175 (76.20/171.07) TYGDMmgahgPNSNNISAGGNTN.PELSTRNNPNN........PRVPtSTIISGDKRNSENT 471- 526 (76.57/ 8.34) THGDM.....PVCENVFEGLNYKyPARRIHTNDNDilnlglhkPKVP.AKVVQPTMNNSTAT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.73| 15| 41| 23| 37| 2 --------------------------------------------------------------------------- 23- 37 (26.73/16.53) LNKSNMVG..ASTSHGK 65- 81 (22.00/12.44) LDKYEIIGyiAAGTYGK --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AAAAAAAAAV 2) SQSSRNMEPMKKKRK | 538 553 | 547 567 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab