<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32610

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSYQVCFKKYVKMRQWPHVLSLRVYASYFLLYNNLPLSSAMVHDGVHLISIKTILTDQPCPNTIYYAKYQVQRKDNEDAASLLEDKEAYLRNQDCIVHAKNDLLFVYDFQAIPSIPEESSSFMLLNSGAFSRLALFQKDELALLLDLYINFLQGLKKTVLYWLCKEYNFVPIYGVLLPLKLHPSFDTQLWNIYGYPVVDLQLSVLSKGHIEFYLKPTRQTVYRLSEVDNLVKKLDTVIRLAPTGCLATLTSVHANASAQTVDALKHRYGFSLTTTSKWVGVTLESSALEFSWPLELCFLETSALRMNDDSLSSNLTDLNNLVLPSNVVNNKKELTEFANEEAEASDKRKEGFTEKEETADAVVTLVPSHSSSPVNYSINSAKSTPASIKVNEEILVADHNVSDDILMEEIDDVGITEADFDYFDLPNVEEKVEMIEPNFANTMTTLDNEEINTSISQSNTSPNLNTHENIPKQMEIQSDDRMVTEDLNPYNVEVDIPEISLNISDSKIPTSAYMPSYYSAVIFPSSISSIFQKYNYGGKYWCPSPSLSTEDLFESFSVAESVTSTDEDICSTNFIQQDFTMEYNHDFFSSSKTPTNISEQSNPDSNYDTLSLAHQVLMNESKSANFDFSFLKSLDLQPTITLGKNDLLNAILSQNLWFRSLPFWKSMTTSFMMSQDVLNFSSYMRKPIRDYLEKILLGESSAVFLSKSPENYLSSINNGHHALNDNPPSQVNFSETLVNFSQPPRVLLKYNEKKLSLDSSAPENWISLCLQPYGESKDFEVFLLSSKSPDVSSKAISFFYDVQLAYENCKLGKLNLSETSINERVMGFSTNINETDNYDDNETTQSDTATSYEQLASVCVNELSGKNVLFFYFLEDDSEKLLKACQHFICVKDSIKRLGDNKFEDKSLRICTIPNSIFDSPNSHTTNSNSFFTKVSLDIYNNDPLLMDGSLKRREPAFLLKKPLLSTLNYQLKDINPRSSALGEYALHVTYTTVEEHLLICNWNDSYGEFETERRYFLQDLEIEDALQQILEVTFTFLNSMHMDWIVIVMKIGEMSDAEYLFWDQAIIPENLQGNVSLTVGYCSAEHGPGSTSKVFSRIPYSASSTVIRNNSSHELSLVAFIREMAMPVPNDEFKKISTILARGYLALDEDESYLPLLSIHLLISRNHDPYLMLNLILKHYLSMIYLQFRTYVSFSSLPLHISTVLYQKQLLQFMASDITHPVTS
Length1225
PositionKinase
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.11
Grand average of hydropathy-0.233
Instability index43.87
Isoelectric point4.79
Molecular weight139259.60
Publications
PubMed=11859360
PubMed=12738880
PubMed=14534314
PubMed=16630887

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000269	PubMed:14534314
GO - Cellular Component
cytosol	GO:0005829	HDA:PomBase
mediator complex	GO:0016592	IPI:PomBase
nucleus	GO:0005634	HDA:PomBase
F:transcription coactivator activity	GO:0003713	IPomBase
P:positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IPomBase
GO - Biological Function
transcription coactivator activity	GO:0003713	IC:PomBase
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
negative regulation of cell-cell adhesion	GO:0022408	IMPomBase
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IC:PomBase
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32610
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     750.89|     210|     218|     368|     584|       1
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  368-  535 (245.55/140.77)	........................................................................................SHSSSPVNYSinsAKSTPASIKVNEEILVADHNVSDDILMEEIDDVGITEADFDYFDLPNVEEKVEMIEPN................FANTMTTLDNEEINTSISQSNTSPNLNTHENIP..K.QME..IQSDDRMVTE.DL...NPYNVEVDIPEIS.LNISDSKI.PTSAYMPSYYSAVIFPSSISSIFQKYN
  536-  751 (276.18/165.25)	YGGKYW...CPSPSLSTEDlFESFSVaeSVTSTDEDICSTNFIqQDFTMEY.N...............................hdffSSSKTPTNIS...EQSNPDS...NYDTLSLAHQV....LMNESKSANF...DFSFLKSLDLQPTITLGKNDllnailsqnlwfrslpFWKSMT........TSFMMSQDVLNFSSYMRKPirD.YLEkiLLGESSAVFL.SK...SPENYLSSINNGH.HALNDN...PPSQV..NFSETLVNFSQPPRVLLKYN
  760-  985 (229.16/126.04)	SAPENWislCLQPYGESKD.FEVFLL..SSKSPDVSSKAISFF.YDVQLAYeNcklgklnlsetsinervmgfstninetdnyddnetTQSDTATSY......EQLASVCVNE...LSGKNVLFFYFLED.DSEKLLKA.CQHF..ICVKDSIKRLGDN...............kFED..KSLRICTIPNSIFDSPNSHTTNSNSFFT..KvSLD..IYNNDPLLMDgSLkrrEP.AFLLKKPLLStLNYQLKDInPRSSALGEY..................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32610 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPNFANTMTTLDNEEINTSISQSNTSPNLNTHENIPKQMEIQSDDRMVT
436
484










Molecular Recognition Features






MoRF SequenceStartStop




NANANA