<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32610

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSYQVCFKKYVKMRQWPHVLSLRVYASYFLLYNNLPLSSAMVHDGVHLISIKTILTDQPCPNTIYYAKYQVQRKDNEDAASLLEDKEAYLRNQDCIVHAKNDLLFVYDFQAIPSIPEESSSFMLLNSGAFSRLALFQKDELALLLDLYINFLQGLKKTVLYWLCKEYNFVPIYGVLLPLKLHPSFDTQLWNIYGYPVVDLQLSVLSKGHIEFYLKPTRQTVYRLSEVDNLVKKLDTVIRLAPTGCLATLTSVHANASAQTVDALKHRYGFSLTTTSKWVGVTLESSALEFSWPLELCFLETSALRMNDDSLSSNLTDLNNLVLPSNVVNNKKELTEFANEEAEASDKRKEGFTEKEETADAVVTLVPSHSSSPVNYSINSAKSTPASIKVNEEILVADHNVSDDILMEEIDDVGITEADFDYFDLPNVEEKVEMIEPNFANTMTTLDNEEINTSISQSNTSPNLNTHENIPKQMEIQSDDRMVTEDLNPYNVEVDIPEISLNISDSKIPTSAYMPSYYSAVIFPSSISSIFQKYNYGGKYWCPSPSLSTEDLFESFSVAESVTSTDEDICSTNFIQQDFTMEYNHDFFSSSKTPTNISEQSNPDSNYDTLSLAHQVLMNESKSANFDFSFLKSLDLQPTITLGKNDLLNAILSQNLWFRSLPFWKSMTTSFMMSQDVLNFSSYMRKPIRDYLEKILLGESSAVFLSKSPENYLSSINNGHHALNDNPPSQVNFSETLVNFSQPPRVLLKYNEKKLSLDSSAPENWISLCLQPYGESKDFEVFLLSSKSPDVSSKAISFFYDVQLAYENCKLGKLNLSETSINERVMGFSTNINETDNYDDNETTQSDTATSYEQLASVCVNELSGKNVLFFYFLEDDSEKLLKACQHFICVKDSIKRLGDNKFEDKSLRICTIPNSIFDSPNSHTTNSNSFFTKVSLDIYNNDPLLMDGSLKRREPAFLLKKPLLSTLNYQLKDINPRSSALGEYALHVTYTTVEEHLLICNWNDSYGEFETERRYFLQDLEIEDALQQILEVTFTFLNSMHMDWIVIVMKIGEMSDAEYLFWDQAIIPENLQGNVSLTVGYCSAEHGPGSTSKVFSRIPYSASSTVIRNNSSHELSLVAFIREMAMPVPNDEFKKISTILARGYLALDEDESYLPLLSIHLLISRNHDPYLMLNLILKHYLSMIYLQFRTYVSFSSLPLHISTVLYQKQLLQFMASDITHPVTS
Length1225
PositionKinase
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.11
Grand average of hydropathy-0.233
Instability index43.87
Isoelectric point4.79
Molecular weight139259.60
Publications
PubMed=11859360
PubMed=12738880
PubMed=14534314
PubMed=16630887

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
cytosol	GO:0005829	HDA:PomBase
mediator complex	GO:0016592	IPI:PomBase
nucleus	GO:0005634	HDA:PomBase
F:transcription coactivator activity	GO:0003713	IPomBase
P:positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IPomBase

GO - Biological Function
transcription coactivator activity	GO:0003713	IC:PomBase
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
negative regulation of cell-cell adhesion	GO:0022408	IMPomBase
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IC:PomBase
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32610
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     750.89|     210|     218|     368|     584|       1
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  368-  535 (245.55/140.77)	........................................................................................SHSSSPVNYSinsAKSTPASIKVNEEILVADHNVSDDILMEEIDDVGITEADFDYFDLPNVEEKVEMIEPN................FANTMTTLDNEEINTSISQSNTSPNLNTHENIP..K.QME..IQSDDRMVTE.DL...NPYNVEVDIPEIS.LNISDSKI.PTSAYMPSYYSAVIFPSSISSIFQKYN
  536-  751 (276.18/165.25)	YGGKYW...CPSPSLSTEDlFESFSVaeSVTSTDEDICSTNFIqQDFTMEY.N...............................hdffSSSKTPTNIS...EQSNPDS...NYDTLSLAHQV....LMNESKSANF...DFSFLKSLDLQPTITLGKNDllnailsqnlwfrslpFWKSMT........TSFMMSQDVLNFSSYMRKPirD.YLEkiLLGESSAVFL.SK...SPENYLSSINNGH.HALNDN...PPSQV..NFSETLVNFSQPPRVLLKYN
  760-  985 (229.16/126.04)	SAPENWislCLQPYGESKD.FEVFLL..SSKSPDVSSKAISFF.YDVQLAYeNcklgklnlsetsinervmgfstninetdnyddnetTQSDTATSY......EQLASVCVNE...LSGKNVLFFYFLED.DSEKLLKA.CQHF..ICVKDSIKRLGDN...............kFED..KSLRICTIPNSIFDSPNSHTTNSNSFFT..KvSLD..IYNNDPLLMDgSLkrrEP.AFLLKKPLLStLNYQLKDInPRSSALGEY..................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32610 with Med13 domain of Kingdom Fungi
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