<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32608

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKASEMARPPMRPGNPHAFASPATTPSRTASPNNAQGANVRTTQGGNQAGASEQQQPLDCFVVYELFASAVTALVSFFLVKDCGAVALNYRTFVSKVEPQQEEGKIVTDLDRLYWLTSVHVHWFSSGTLLVSTSTERTLALQCLGDLSEDEQQKLVDRCIRVAPNAMLASISSFDDPRQLSADDSNRRTSKKKAKMDSLEQNIEKWRMSVQRWLSRRGYSLPNLDKNSAWVTIRVGQLAQFPAMSPHLPTSARDVLWPRSLCFMQSLVPDDLKWFEVPGSAGFRDPIDAAQDWFTGQLERDKILDMQRKAKKAEEDAMRRKDEAPGLYPSSPFTARTGVYGDLQPVSGVYPTPPDGIVPGTGISSTDTPSVSGTASNVVLVPGGNTPAINLSAPQDYTTTDNQQHASTSPTFPAPLEPFQTSGEDDDLFEDMEGDGFGGPDVEEADFDFFDGPDGDDVNMADAPALPETTNKPHKQLNNDVAMAHEEEHSVKEEMSDPLAALESALAAPYRPINDGMPEEKVSEKEAKAVVPVEALATSPAQIKQNPPAKKEATPPLSPSAIAKTLQPSPPKKQSSFPASLQRTNSAFHSLDFSRRLSLVDAKYQDGRFAARIEKTEDDESAVNPGRLKSLKDLPLLNKLRYAVASASTAKSTEALSLARAVSDDSASDSESETSDMSEGSPEDPVDTHPLPYLGRLIIPAKRKLPTEGHGTPLSVTSFAESLAGDWQDSNSLLLDESSLTFFEPNTWDWSIPDLSMEPPEEKPLNGKESIAVTQILTDQIVSATLDLLDENALVESTSSIEPSSETRWQICIKELFPKAAECTLSALIAIHDVFPDLSAQAKGQQRPPPRKPNESNAIPSNHMYPMNPPFIRVRRAETHWDLLPPSIAFWEPLGLAPASPPKNVVAFCIYPHSASLRPILDRFMLNLQLAYDTCKLGSHARVETVIEYEGGLVPVKANSQTSAKEAFRALKDTCIQLGKLLAIQYAQLGEQQDTKIDAFVVYMVDPFGNPAALWELCSAFWSLFQAYGQGPPGRSDPTPKPDLVLQIIPIKYLASFDVPVILDAATYVSLAREVYDRCPPSVASTDKTPLSIYKAPAFQLEESLPRNVQFKLLSEPPQDLLRENSYMHIAYAISLDGNWLTAAWSDSCGKSQAVVSYHLGTRVFGDIAKEIWQTTIEILQARRVQWRVCIAKSGPLDREELETWVLLITCPTQVNLFLTILTVIEDPPYKFTPTTPAPSNSSAQANTNTPGSTPQTGVSPDPTIGLTPAATPSADPAPDPAADPEARLIDVTDETWGIILAHRLHNSNSTNQFSPALISGLLVKRGITHATSNSIHHPIPDPLPGPITVAVNILWIGAVGSTWKRAAESRGTQY
Length1375
PositionKinase
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Phaeosphaeriaceae> Parastagonospora.
Aromaticity0.07
Grand average of hydropathy-0.358
Instability index50.64
Isoelectric point4.96
Molecular weight150057.10
Publications
PubMed=18024570

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32608
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     697.36|     235|     329|     296|     620|       1
---------------------------------------------------------------------------
  238-  573 (331.17/234.13)	LAQFPAMSPHLPTSARDVLWPRSLcfmqSLVpdDLKWfevpgsagfrdpidaaqdwftGQLERDKILDMQRKAKKAEEDAMRRKdeapglypsspftartgvygdlqpvsgvyptppdgivpgtgisSTDtpsvsgtasnvvlvpggntpAINLS.APQDYTTTDNQQHAS....TSPTFPA...................PLEPFQTSGEDDDLFEDMEGDGFGGPD..VEEADFDFFDgPDGDDVNMAD...APalPEttNKPhkqLN..NDVAMAH...EEEHSVKEEMSDPLAALESALA.APYRP......INDGMPeeKVSEKEAKAVVPV.EALATSPAQIK.....QNPPAKKEATPPLS...PSAIaKTLQP.SPPKK
  574-  870 (304.20/146.61)	QSSFPASLQRTNSAFHSLDFSRRL....SLV..DAKYqdgrfaariekteddesavnpGRLKSLKDLPLLNKLRYAVASASTAK...........................................STE....................ALSLArAVSDDSASDSESETSdmseGSPEDPVdthplpylgrliipakrklPTEGHGTPLSVTSFAESLAGDWQDSNSllLDESSLTFFE.PNTWDWSIPDlsmEP..PE..EKP...LNgkESIAVTQiltDQIVSATLDLLDENALVESTSSiEPSSEtrwqicIKELFP..KAAECTLSALIAIhDVFPDLSAQAK...gqQRPPPRK...PNESnaiPS...NHMYPmNPP..
 1011- 1053 (61.98/20.71)	....PAALWELCSAFWSL...........................................................................................................................................................................................................................................................................................................................................fqaygQGPPGRSDPTP..K...PDLV...LQI.IPIKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.73|      10|     566|     323|     332|       2
---------------------------------------------------------------------------
  323-  332 (20.60/10.30)	EAP..GLYPSSP
  343-  354 (17.13/ 7.12)	LQPvsGVYPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.97|      18|     129|    1079|    1106|       6
---------------------------------------------------------------------------
  885-  902 (39.13/20.52)	PPSIAFWE..PLGL..APA.....SPP
 1080- 1106 (19.85/31.49)	PPSVASTDktPLSIykAPAfqleeSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     164.40|      37|    1240|      16|      52|       7
---------------------------------------------------------------------------
   16-   52 (67.33/34.85)	PHAFASPATTPSRTASPNNAQGANVRTTQGGNQAGAS
 1229- 1260 (59.50/29.80)	PYKF.TP.TTP...APSNSSAQANTNTPGSTPQTGVS
 1263- 1288 (37.57/15.66)	PTIGLTPAATPSADPAPDPAADPEAR...........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32608 with Med13 domain of Kingdom Fungi
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