<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32607

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKKEVGDACRLEDIVTNLYRLETVKQINYHQYVPSKADNQWSIQAELFLRRKNPKVLAALFSRELWCFSINDDPLPELNLELNNESESPQPERKGHFTPEFSKPHLPTPYAIFMKALRRMIYVNLTLSSNETIVPFGNSCIFQESYTFSTKILHFDPHLFENGDLTVAICSKDLGLSKLNAESLKHEVAVYLAPSGIRVYLPSTDLKKCYVSPPKNAQMFLKTLFVSHGINLIDVDGLKWVKLIPNANHLNGFTPTISHYLDEPKGNNFVIWPACLCFVQTASDVQTPQYTAFSRSPQLELDDCFDMIDGFIQLKLTSAYRTPGTSAGMGTVTGHNPLSTGGIFTDQFQGFNKHSANNSNNVSSTGENGKFSPEYSNDPNVTPLRDNKTSRQNFPTESYSSNGFITTPIINENITPTVDDIITETPSVKPQNDLWNEKKDVINSTSNINSKDASVGSSERKVELETAFESPAQNISIEEHEHVEFDKDLFGEDSDEDVSTRNKNEELVSVKEITDEMFDLAEDDDEADGSTSNSLKFDRPDTIESIDTDEKKTRTKRTYLDIPVDVITIEKTPTLYEDPGAPLPIETPKDRKKSIFAPLNFNPIFESNVDNKYKNGGKFSVNSNTNDEPIQFGISTSNISSSEDDDSDFSPADFNNNGPSAGKGLSYDPRDNDIPMIESSTYEPIAKDSLPELINPPSSSKDDSVASYNTIGTLMEKPVKSNLDAIWKPALSKSERADLPNQTINGVINDCNNSSNSNPTTYFENTPSLGPDTLYDNSKPRSSSANFLSTVEIDPKSEQTIQTAEQEQSESSRILPYLLRHMPLFSLPDVFLCQNPSLPPGKDFEDILEILTDQIVFNNDMFSDDRATESQFKGIKDCSVGTISDTMNQLFGNFSKLHGNEIIEEVFYLPEPSVFVKKSEDTIKIKSSSCYFTEYLNLKPNRGVKNFRALVLTTEAKNDCMSFVSQMSQTYSNHELGFCELTKLTNDDNKGLIYLKNFNQDTLLLLSAQIVSFCSTALSNIKNIPLLIFLPINKLSLTECISMILKFHVIRKEFKSKLPKADILLRLVNIDFLKNPLTPITAYTSLCMAIYNSLPPKSTKVTSLTNDLPKQIEFRTLKNASLSIHYDNYIHLAYLRSIDREWLCAAWSDTKGVESFVKTWYVGNSRTRFEQVCNDIWKITLQLASKNFGNVCLVLTRLDSVLPDDELIHWRRLSVATKDLHLAVVCVGDNTKLTLFDEDKTYPTFKNLFRTKSNPQTGISNSIDDLEIINIDEEVHGLIFSNPLQLANSQHRCAIKSGALIRFAKSEGDNFIDKFEVNLLNCPHADSSTLLKEILKQYRNLAGLNPWFGVSYGKDNFIPWHVVAVKNVMNSIVHVKSSFEKETHIID
Length1387
PositionKinase
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.09
Grand average of hydropathy-0.424
Instability index37.45
Isoelectric point5.08
Molecular weight155990.68
Publications
PubMed=15229592

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32607
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.93|      54|      55|     485|     539|       1
---------------------------------------------------------------------------
  485-  536 (80.77/43.91)	......FDK.DLFGE.DSDEDVSTRNKNEEL.VSVKEIT.DEMFDL.........AEDDDEADGSTSNSLK
  538-  589 (60.03/32.37)	DR.......pDTIESiDTDEK.KTRTKRTYLdIPVDVITiEKTPTL.........YED.PGAPLPI.ETPK
  590-  653 (61.13/28.74)	DRkksiFAP.LNFNP.IFESNVDNKYKNGGK.FSVNSNTnDEPIQFgistsnissSEDDD.SDFSPAD...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     333.83|      81|      81|     751|     831|       2
---------------------------------------------------------------------------
  656-  697 (49.68/19.58)	.............NNGPSAGKGLS.YD......PRDNDIP.....MIESSTYEPIAKDS...............L.PELI.NPP........
  699-  746 (37.43/13.06)	..SSKDDSVASY..NT..IG..TL.ME.....KPVKSNLDaiwkpALSKSERADLPNQTI.NG.............................
  751-  831 (141.19/68.29)	CNNSSNSNPTTYFENTPSLGPDTL.YDN...SKPRSSSAN.....FLSTVEIDPKSEQTI.QTAEQEQSESSRIL.PYLLRHMPLFSLPDVF
  833-  915 (105.53/49.31)	CQNPS.LPPGKDFEDILEILTDQIvFNNdmfSDDRATESQ.....FKG...IKDCSVGTIsDTMNQLFGNFSKLHgNEIIEEVFYLPEPSVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     282.67|      88|     271|      83|     173|       3
---------------------------------------------------------------------------
   83-  173 (150.11/77.68)	NNESESPQPERKGHFTPEFSK.PHLpTPyaIFMKALRRMIYVNLTLSSNETI.VPFGNSCIFQESYTFSTKILHFDPH..LF.ENGDL...TVAICSKD
  357-  452 (132.56/60.70)	NNSNNVSSTGENGKFSPEYSNdPNV.TP..LRDNKTSRQNFPTESYSSNGFItTPIINENITPTVDDIITETPSVKPQndLWnEKKDVinsTSNINSKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.93|      32|     880|     176|     218|       6
---------------------------------------------------------------------------
  176-  218 (38.99/49.58)	LSKLNAESLKHEvavyLAPsgIRVYlpsTDLkkC...YVS.PPKNAQ
 1065- 1100 (50.94/29.14)	LRLVNIDFLKNP....LTP..ITAY...TSL..CmaiYNSlPPKSTK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32607 with Med13 domain of Kingdom Fungi
Unable to open file!