<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32605

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMKEATDDYDLSKLVSNFYRLEKITKINYAQYLPKKQNDQWGIQMEIQMRKKDRKLLVALLSKELWCFSINDQVLPSPNDIDPELNVSADKTGSFTADYSKPNLPPHYALFLKSLKRMIYLNLVEQSKNTLVQFGNSCINITKNNESNNLLQIEPHLFSNSELAISICVKDLGLLPLKVNSIDPAFLSSHALYMAPSGVRVYLVENKNDNSGTNQEHLHKYLVPVPENGEVLLKTLYASHGIKLNSSTCQWVNIIPNITHLNGRAPNISQYMDLPKELRTIVWPLDLVFAQPALDIDSSTTLSQINGLDTFEDTLSLIDNFLQLKQSSSYRTPGSSGGLTGTNIGTNVFSSEGAYTDQFQVYPKSQTNQQQTSSNSKVSPSDAASPYPGIDKIIEQKQFTPDFMASPSVSGNSNELFNDRKNGHTDLLISPSKMDVDTDFPGSNLAGQEAPSQPASDVKKSSVSASDSELFGEEDEDEDDADLFGESNNDSTGESNANNSKGEITEDIFASSDDESSLQPKKESTFYDGIKNGSAESGLNMQDRANLKRTYLDIRIEETPLSSPLYTDPGAPLPVETPRDRRKSVFAPLNFNPIIAKDVDNKYKNGGKYSFSPLQKEEALNFDVSRTELSSSEGEDSESSDDELEDLANKNDGVVYDKAENIGYKTFANLQDSVPPGLIKQDFLGNPYLASLEGSKEGQNTIWKMPQTDIAQTESPLKAIDTSIGPDGTLPNTTSSEQSKSVYVHDYGISPTKMSNDPAFDTAKIEGKYEFMNNFPSSFPFLLRHMPLSLIPDTFKHLNPTITVNERNNQIIDLLAEQIVYDYNILGNLTIPDVPYSGIRNYSNGVVKNTIDNLFSEFTRLDGTTLISRLYPMETPFVSVRKQHDQIKLRSDVQQFTKYANLKPVRGIKNFKFLVLTDSFKEDCIQFISSLSQTYINHELGFCEHLQLTNEDSKGLIYLKDFEDSKLLLLAAQIVSYLSTNRTSGKEVAFMMIIPVQRCDISELVEKTAKFQIIQNEVKAKIPSMELYLKIVPMDFIKSPLTSVDDYTNLCISIYNILPNKMIKFTHIRKQIPEKLTFKTSQQASAFKYDAYIHLAYSRSVDKQWMFAALSDSAGKENMMKTWYLGSSKNKFDEACNHIWEMALSLAGKNYGKVCLILTRLNGILPDDELMNWRRLSGRNIHLAVVCVDDNTKISFFDRNESYPSYKRLYQNANSIETLVDPERIDDYLIRDLDQDIHGVIFENPFPLVNSLHRCAIKSGALVKFNVSTTATEPHSLDKFEVNLLNCPHSDSFKLLETILEEFRNLAALNVWFGITNGENGHIPWHVLAVKKMMKTLVHTRVKVAQ
Length1345
PositionKinase
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Nakaseomyces> Nakaseomyces/Candida clade.
Aromaticity0.09
Grand average of hydropathy-0.436
Instability index42.42
Isoelectric point5.21
Molecular weight151206.71
Publications
PubMed=15229592

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32605
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     637.58|     155|     159|     452|     610|       1
---------------------------------------------------------------------------
  290-  451 (215.01/129.97)	QPAL.......DIDSSTTLSQINGLdtF..EDTLSliDN..FLQLKQSSSYRTPGSSGGLTGTNIGTNVFSSEGaytDQFQVYPKSQT....NQQQTSSNSKVSPSDAAS.PYPGI...................DKIIEQKQFTP.DFMASPSVSGNSNELFNDRKNGHT.DLLISP...SKmD.VDTDFPGsnlaGQEAPS
  452-  610 (253.16/163.71)	QPAS.......DVKKSSVSASDSEL..FGEEDEDE..DD..ADLFGESNNDSTGESNANNSKGEITEDIFASSD...DESSLQPKKEStfydGIKNGSAESGLNMQDRANLKRTYL...................DIRIEETPLSS.PLYTDPGAPLPVETPRDRRKSVFA.PLNFNPI.IAK.D.VDNKYKN....GGKYSF
  611-  770 (169.41/100.62)	SPLQkeealnfDVSRTELSSS..E....GEDSESS..DDelEDL..ANKNDGVVYDKAEN....IGYKTFANLQ...D..SVPP.................GLIKQD..FLGNPYLaslegskegqntiwkmpqtDIAQTESPLKAiDTSIGPDGTLPNTTSSEQSKSVYVhDYGISPTkMSN.DpAFDTAKI....EGKYEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     343.16|     108|     837|      10|     127|       5
---------------------------------------------------------------------------
   10-  127 (174.03/119.44)	LSKLVSNFYRLEKITKIN..YAQYLP....KKQNDQWGIQMEIQMRKKDRKLLVALLSKELWCFSINDQvlpspndIDPElnvSADKTGSFTADYSKPNLP..PHYALFLKSLKRMIYLNLVEQSK
  850-  965 (169.13/97.30)	IDNLFSEFTRLDGTTLISrlYPMETPfvsvRKQHDQIKLRSDVQQFTKYANLKPVRGIKNFKFLVLTDS.......FKED...CIQFISSLSQTYINHELGfcEHLQLTNEDSKGLIYLKDFEDSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.97|      43|     801|     220|     265|       6
---------------------------------------------------------------------------
  173-  220 (62.03/43.32)	LLPLKVNS..IDPAFLSSHALYMAPSGVR.VYLVENKNDNSGtNQEhlhkY
  221-  270 (58.93/54.16)	LVPVPENGevLLKTLYASHGIKLNSSTCQwVNIIPNITHLNG.RAPnisqY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32605 with Med13 domain of Kingdom Fungi
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