<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32604

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVGANASSISTQYYKLAHLGSISYTIYTSSDNNDQALLELELTIRHKWPQILVTYYNKSLYYFVFGHNKVDSETIDLTKEFPQLSTKYTDTVNVDQFPNPHKSTKNDDNLAWASLSFLKATKKMILYNLSLSGAIKLFGNYCVAPTGDSVYSILCIDPILFQNGDLVVSCVEKPFTQLFSSSVAYPRNLAIDTNFVIYLIPSGIRCHLFDPTSLRNNLIEKPQIENGKLLELLKITTGVQCDESTLWVKLIPNLKHLNNQTSAIGKFIHSVENKKFILWPWDLCLLQFGKFEPAIEEEGLLESSELNNPLHLISDFLDFRIAHNTQLQQQRDSLSDQQQGETVNVPLSAGSVHATGANSFGNVPDISKDVDTVGLSTTTPIETDLFNLQNTEEFFKNDSIHMNLEDQIHKKETEPENESENDMEIDDLFGGDESDDNDDLEEAGNEEEKPTPSNNTIDKNGVIGNALEEAFIADATPSKENINLDSKIMPPDSTSEEAVPDKENFKPKETKPSYIDILKDKMTIEKIVNSPDYKDPGAPLPVVPTPLVSSTVSQSAVTTNPPSVGSAPGPAPGPAPGTETLYEANNAYAQSSQISQLPQQKSAFSPILFNPIIKSDIDTKYGKGGKFYVAKDSSTNGNLDMKNRSLRATSVSGMEIPFSSEDKKRLQQNLEVLDSSTTSDNEGGEDIEDDDNDYEDEGDDDEEEEGEEEEEEESDEDEISDIGKSTPLKLNTQNESVPPQQSNYNPVNITDSGSNTTNNITDKQGYENTEGFGTPFPNQISKYSIKPESPFASNELQSSVSPMYFDTSQSHQSPQLQPSTGTLEVLKASSLESPSKISESSNYLPLILRSINVSTIPSSYLMNNLISSKLLPSFTISDDDLENDLDITKSNEMIVKLGFLKEFLDFMSPNIIFDLGLMKNDESDYYINGVNDLLLNSDPGISSDWILNSLSKVFPCTYPMKLIELLYDFKSLELEDQLDSQLNFLNEIADEEDFVGPKALYRKLKALEWDSFSLNESNKTSFEKYKNVMEKLSAENTVSDDDYFKLPMVKTRILKNGNIVNLNNIGLKFWKYLNFSPVKKQKDFQILLIAETHRNTASYATEFLDQIIQNYKECNFGTISKVNLSTVETRSDLEPISDGLVLVHKEHDQSYNDFYIQTNKKLISLVELIKLDLINKTNNFEFGKPLLLFFIDFNDSSNSNVQVCKIFRNFKVALTTHQLPLVDIFTKIVPSSLLVKKVHHETALKVFSNYKLTKISMNLYNECPNDLANKSIVKNLFTTIVKDPPSKIQFKFMNSSYRDNSSNDDIFLHLAYERSIDNSWFVASWSDPLGRVVHVKSWYCSDSVSKSEKSTYRGDIMDIMSITDDIWSISTDLFKVLNDELGSFGGKKFLVLTRINSIIPDVELVHWKRLSSKHKEISLIVVSVRQTPRIVGSNESEDLGPKSNDYAPTPMIQDKDIFFGFKQTFSTSNTSSPSASGGALVTSPNSLSLHSPQQFLNAPANFLSPQDLIAPTSSGISGAKPGSSGIDPEVVLENQDNEVYGVIPKVPLPSFNSPTRFCMKTGYLMMQVNQPSEEEYKDDIKKTYLVYEINLLSCSNYWNLDVLMKLIMSQYKQMIALNDILCMNPIVGESDILGTHSRNNAIVPWHINAVGKLLDYLVHIYVDKD
Length1665
PositionKinase
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.419
Instability index42.78
Isoelectric point4.67
Molecular weight186569.02
Publications
PubMed=15123810
PubMed=17419877
PubMed=24025428

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
integral component of membrane	GO:0016021	IBA:GO_Central
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
sugar transmembrane transporter activity	GO:0051119	IBA:GO_Central
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
carbohydrate transport	GO:0008643	IBA:GO_Central
filamentous growth	GO:0030447	IMCGD
hyphal growth	GO:0030448	IMCGD
positive regulation of single-species biofilm formation on inanimate substrate	GO:1900233	IMCGD
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
single-species biofilm formation on inanimate substrate	GO:0044011	IMCGD









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     209.78|      42|      57|     419|     460|       1
---------------------------------------------------------------------------
  384-  418 (35.03/15.85)	........DLFNLQNTEEffkNDSI.HM.NLEDQIH.KKETEPENE
  419-  460 (69.02/39.38)	SENDMEIDDLFGGDESDD...NDDLEEAGNEEEKPT.PSNNTIDKN
  478-  520 (54.22/29.13)	SKENINLDSKIMPPDSTS...EEAVPDKENFKPKETkPSYIDILKD
  683-  719 (51.50/27.25)	GGEDIEDDD..NDYEDEG...DDDEEEEGEEEEEEE.SDEDEI...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1052.43|     265|     266|     852|    1117|       2
---------------------------------------------------------------------------
  852- 1117 (436.00/245.85)	NVSTIPSSYLMN.NLISSKLLPSFTISD.........DDLENDLDITKSNEMI.....VKLGFLKEF..LDFM.SPNI....IFDLGLMKN.DESDYYINGVNDLLLNSDPGISSDWILNSLSKVF..PCTY..PMKLIELLYDFKSLELEDQ..LDS.........QLNFLNEIaDEEDF.VGPK....ALYRK..LKALEWDSFSLNESNKTSFEKYKNVMEK..LSAE.NTVSDDDYFKLPMVKTRILKNGNIVN..LNNIG....LKFWKYLNFSPVKKQKDF...QILLIAETH.RNTA......SYATEFLDQIIQNYKECNFG
 1123- 1385 (311.77/171.07)	NLSTVETR.........SDLEP...ISDglvlvhkehDQSYNDFYIQTNKKLIslvelIKLDLINKTnnFEFG.KPLL....LFFIDF..N.DSSNSNVQ.VCKIFRNFKVALTTHQL..PLVDIF..TKIV..PSSLL.....VKKVHHETA..LKVfsnykltkiSMNLYNEC.........PN....DLANKsiVKNL.FTTIVKDPPSKIQF.KFMNS......SYR.DNSSNDDIF.LHLAYERSIDNSWFVAswSDPLGrvvhVKSW.YCSDSVSKSEKSTyrgDIMDIMSIT.DDIW......SISTDLFK..VLNDELGSFG
 1396- 1661 (304.66/166.99)	N.SIIPDVELVHwKRLSSK.HKEISLIV.........VSVRQTPRIVGSNES......EDLG..PKS..NDYApTPMIqdkdIF.FGFKQTfSTSNTSSPSASGGALVTSPNSLS...LHSPQQFLnaPANFlsPQDLIAPTSSGISGAKPGSsgIDP.........EVVLENQ..DNEVYgVIPKvplpSFNSP..TRFCMKTGYLMMQVNQPSEEEYKDDIKKtyLVYEiNLLSCSNYWNLDVLMKLIMSQYK......QMIA....LN..DILCMNPIVGESD........ILGTHsRNNAivpwhiNAVGKLLDYLVHIY......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.98|      44|      54|     741|     784|       3
---------------------------------------------------------------------------
  741-  784 (77.95/49.54)	QSNYNPVNITDSGSNTTNNITDKQG.YENTEGFGTPFPNQISKYS
  797-  841 (69.03/42.89)	QSSVSPMYFDTSQSHQSPQLQPSTGtLEVLKASSLESPSKISESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.57|      22|      47|     207|     230|       4
---------------------------------------------------------------------------
  207-  230 (33.22/29.07)	HLFDPTSLRNNLIEkpQIENGKLL
  256-  277 (38.35/25.62)	HLNNQTSAIGKFIH..SVENKKFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.18|      14|      15|      73|      87|       8
---------------------------------------------------------------------------
   73-   87 (20.06/15.23)	ETIDLtKEF..PQLSTK
   90-  105 (21.12/10.83)	DTVNV.DQFpnPHKSTK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32604 with Med13 domain of Kingdom Fungi
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