<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32603

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDILETSFRLEDVLSSYYRVEKVVRVNYQQFVPRTPDDQWCIQSELLIRKKDPKALVALFSRELWCFSINDQDLPMPGLEGIGEPPNSEKKGHFTPGFSKPNLPTPYAIFLKALRRMIHINMCLRSQNRLVPFGNTCIFQRDEKASSVIHFDSHLFENGDLTVSLCTKDMGFERLLSGAFTGRQVKRALYLAPSGIRAYLPFPDISKCLVAPPKNAHLLLVTLLVSHGIDLTQAKDLKWIKLVPNINHLNGYTPTISRYAEESQTSKSVIWPMDLCFQQTPADACVNTTRATPLDIGLQDSFDLIEDFIQLKLTSAYRIPGTSVNANTATGNNPLSTGGGFTDQFQPFVKHTNSSSCNYGPASRTKLTPSKAQDLRRSAAPLSADSFGNGFMTTPNVNENMGSVIDDMVICPSSVKSQNDLWNDRKSSNDDIDSINPTSQQGDSARITSGSEEQDVEVTFDKDLFGDEDDESDLFGDSSNKSTHRKEVREITDEMFDSAEIESDPEGKITPTGTSINYSTQQQTPLKRKYLDIPLDEITLPAAPLYTDPGAPLPVETPRDRRKSVFAPLNFNPMIESNVDNKYKNGGKFSFDPNEIDEPLKFEVSTTNISSSEEDDSEFSGDDFDELQQNNLQDIRAMEVGSSLQQYDMGRPINEFLNQSDSAKEDYLLPAYQSGDVIDVDKFPSRESHLDQIWKSPEINREDTPHRIGLPIIKPQLDGSGNLDIDNQITDNCSSNYYEPTPVVGADEKIQERTLHKDKKLDQQGDSAMASVVGDYSLAIKETRESSNGLPFLLRHMPLFSIPDVFLSKNPIVKVDSKLEDFLEILCEQLVFDQGFLGNFDVDPPTYKDVKLNEKGVIRETLNSVFSEFERLRGNEIISDMFYIKQPSVCVKKHGNLIKLKSDAESFAPLLHLKPSRGMKSFRGLFLTTILTQTCVSFITELAHIYSAQELGFCELVKLTNDEHNGLIVLNNFNTDTLLLLSAQIVSYCSTNMNNVKNIPLMIFLPVAPSSLEATITMTSKFQLIKNEVKSRLPDVELLLKLIPFDLTKDPVIMIDRYYELCRGIYNLLPPRTVKFASIADNLPEQVEFRTSAGNQNQLSHYDSYIHLAYTRSIDREWLAAAWSDSKGTENMVKAWYLGNSKARFETACNELWKLTVELASRKYGRICLILTRMDSVLPDDELMHWRRLSVTTRNLHLAVVCVGASTKVSLYDEDQFYPSFKPLFKDKRYANKIQANQLDDYEVVNIDEELHGVVFSSPLQLANSQHRCAIKSGALVRFKRCAGGDTLDKFEVNLLNCPHSDSTKLLKTILHQFRDIASLNTWFCISRGKDNYIPWHVVAVKKIMRFIIHVNGIEEK
Length1357
PositionKinase
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.09
Grand average of hydropathy-0.383
Instability index39.45
Isoelectric point5.29
Molecular weight153089.64
Publications
PubMed=15001715
PubMed=23749448

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     299.56|     106|     243|      28|     171|       1
---------------------------------------------------------------------------
   28-  159 (151.99/175.09)	Y......QQFVPrTPDDQWCiqselLIrkKDPKALVALFSRELWCFSIndqDLPM.PGLEGIGEPPNSEKKGHFTPGFSKPnlptpyaiFLKALRRMiHINMCLRSQNRLVPfGNTCIFQRDEKASSVihfDShlFENG
  190-  258 (78.51/54.34)	YlapsgiRAYLP.FPDISKC.....LV..APPKNAHLLLVTLLVSHGI...DLTQaKDLKWIKLVPNINHLNGYTPTISR...........................................................
  339-  390 (69.06/36.77)	.......................................................................GGFTDQF.QP........FVKHTNSS.SCNYGPASRTKLTP.SKAQDLRRSAAPLSA...DS..FGNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.33|      27|      72|     501|     527|       3
---------------------------------------------------------------------------
  501-  527 (45.82/25.34)	IE..SDPEGKITPTGTSINYSTQQ.QTPLK
  528-  554 (35.13/17.65)	RKylDIPLDEITLPAAPL.Y.TDP.GAPLP
  575-  601 (37.38/19.27)	IE..SNVDNKYKN.GGKFSFDPNEiDEPLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.54|      31|     244|     400|     433|       4
---------------------------------------------------------------------------
  401-  433 (51.39/36.89)	MGSVIDDMVICPSSVKsqNDLWNDRKSSNDDID
  649-  679 (52.15/26.76)	MGRPINEFLNQSDSAK..EDYLLPAYQSGDVID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.48|      18|     160|     447|     467|       6
---------------------------------------------------------------------------
  447-  467 (24.04/23.46)	ITSgSEEQDVEvtFDKDLFGD
  609-  626 (33.44/19.30)	ISS.SEEDDSE..FSGDDFDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32603 with Med13 domain of Kingdom Fungi
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