<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32601

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNSSAPSPGPSSRLYRSINSRDDLSQQRYVLRPPDDIHPLVDPARIGDSVYPDFYPWKRSTDEEDARMVDNLQKGYAEPPSVPHESQSAKKSIASLLRIKSNMTALSCFIITAMHIRVDTCRITTPGTFKPPPRVTLTDHKREAWLKDLANPAVPLRKLSRTIPHGIRNKVLLDQCCAKRIAPSRAVWFARCVGANELRGLKRKGHHQMGNMSEAIWLQEWTECVVDVLQRSSVAFLRAEGEPQARQTAKQNFAYMWVVGLLSDDNTKDTKAGSGVAPGTGASTTSKLSSVEKLPVAILIIRTFWKPLLTFPNLAKKLAQNLLAELSKLEADAHSDKPFYQPTIKALSTLVNALFDAQPDAFVMPSKWVQLGSTFEAIVSDSESTRVRNEALVISDTPKTRRTRNKQAVIISILDAARAPFDKTLFNQIVDTRADFGTIIQTILAWAVSDSRVSVERVFIASHLVSQLSEGVDGDAVPSHIVQFLLSVKSHLDVRIDDLYALVTELCVLDIFQPQDYVRSLISSGVLYISRLSEWANVQLDILGNLPLVAVPSSCQVQVRYMVRKVAKYASYNENELLERTNNALRVLLPGVFDSQAEDVDMSSSSSSLSDSTNIPYSEFTQNTRIVVAENLYTSLCAAVERGYVPTTQEFAQYQLILENLHAWRLMCASIQLIVPKCTQSHLLYFLASATRYQWQAFACIADMPALVKVFMHQYRGLRKVRVSRELWDLVQFSAQQLPELKPELETLLKNSSSPQLSPISEVTPQTDSEATKDVNLPQALNDLLLHSSDVRTSCKMLANYKDDSQFSNQLMTWLRDQEVSLQLLQTLVFLVVYECTCIEKVGDLFLQIHNLRDMSGGSRLLLSLIARDLTQEYSLSTTEAFSLQFQRKLFADQHPRIYLRLVAQYLFEREVFQDPQWLDDVDTFCKEVAVHHPALFSQLIVDPVIEPDNAVAASSLQQLLNHLLKLDLGTGTSLADDLQQLITHVTPFNMFLAQTQLRLLFAHRGRISKDPVAMDTSPELTINSTTPSTDTTDEDVSVLFRVLSDPGLLKLPPFFGDLFSELPGELKGRILARAETTFLTSPNFPRVGEDNIVSLLIELADSLADSVTEDVCKTQTFALSSGLQRLVEASVREPHPPGLAEGISMFLKIAMIHEKSLMASEDAEVTMLRNHVVEGLQALLDSPFVATTPDLKATLQDTWTALKSELSEVAEPANSAPSKAGPTRDLLLYSTANDAFSEVTVRSFDLLEESNPTMGVNDAALNLALFNATIEKRIPIAWNNGHKRQLVDGGRGGRKTARGTDSSLVPTILEGIPRCMDEYSNHWELFFCFYLYTMRASEVHDLRANRASSFERRASSVELLA
Length1362
PositionKinase
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Dipodascaceae> Yarrowia.
Aromaticity0.07
Grand average of hydropathy-0.133
Instability index45.18
Isoelectric point5.74
Molecular weight151976.75
Publications
PubMed=15229592

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32601
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.35|      28|      29|     636|     664|       1
---------------------------------------------------------------------------
  636-  664 (47.10/32.84)	LCAAVERgYVP.TTQEFAQYQLILENLHAW
  667-  695 (45.25/26.58)	MCASIQL.IVPkCTQSHLLYFLASATRYQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.45|      42|     461|     743|     788|       2
---------------------------------------------------------------------------
  743-  788 (65.16/45.49)	PELETLLKNSSSPQLSPISEVTPQTDSEATKdvnlPQALNDLLLHS
 1190- 1231 (71.30/41.12)	PDLKATLQDTWTALKSELSEVAEPANSAPSK....AGPTRDLLLYS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.36|      23|      39|     939|     963|       4
---------------------------------------------------------------------------
  939-  963 (30.24/27.41)	QLIVDpViEPDNA.VAASSLQQLLNH
  981- 1004 (37.11/22.44)	QLITH.V.TPFNMfLAQTQLRLLFAH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.75|      18|     843|      12|      31|       9
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   12-   31 (23.93/23.46)	SRLYRSINSRdDLSQQrYVL
  859-  876 (30.81/18.55)	SRLLLSLIAR.DLTQE.YSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.13|      13|      35|    1007|    1019|      10
---------------------------------------------------------------------------
 1007- 1019 (23.19/14.76)	RISKDPVAMDTSP
 1042- 1054 (22.95/14.51)	RVLSDPGLLKLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.17|      16|      38|    1078|    1093|      13
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 1078- 1093 (29.03/17.97)	TFLTSPNFPRVGEDNI
 1117- 1132 (25.14/14.54)	TFALSSGLQRLVEASV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     295.90|      96|     237|     286|     387|      18
---------------------------------------------------------------------------
  286-  387 (141.93/111.30)	SKLSsvEKLPVAILIIRTFwkPLLTFPNLAKKLAQNLLAELSKLEadAHSDKPFYQPTIKALSTLVNALFDAQPDAFVMPSKWVQLGSTFEAIVSD.SESTRV
  530-  626 (153.96/101.09)	SRLS..EWANVQLDILGNL..PLVAVPSSCQVQVRYMVRKVAKYA..SYNENELLERTNNALRVLLPGVFDSQAEDVDMSSSSSSLSDSTNIPYSEfTQNTRI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32601 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) APSPGPSSRLYRSINSRDDLSQQRYVLRPPDDIHPLVDPARIGDSVYPDFYPWKR
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