<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32601

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMNSSAPSPGPSSRLYRSINSRDDLSQQRYVLRPPDDIHPLVDPARIGDSVYPDFYPWKRSTDEEDARMVDNLQKGYAEPPSVPHESQSAKKSIASLLRIKSNMTALSCFIITAMHIRVDTCRITTPGTFKPPPRVTLTDHKREAWLKDLANPAVPLRKLSRTIPHGIRNKVLLDQCCAKRIAPSRAVWFARCVGANELRGLKRKGHHQMGNMSEAIWLQEWTECVVDVLQRSSVAFLRAEGEPQARQTAKQNFAYMWVVGLLSDDNTKDTKAGSGVAPGTGASTTSKLSSVEKLPVAILIIRTFWKPLLTFPNLAKKLAQNLLAELSKLEADAHSDKPFYQPTIKALSTLVNALFDAQPDAFVMPSKWVQLGSTFEAIVSDSESTRVRNEALVISDTPKTRRTRNKQAVIISILDAARAPFDKTLFNQIVDTRADFGTIIQTILAWAVSDSRVSVERVFIASHLVSQLSEGVDGDAVPSHIVQFLLSVKSHLDVRIDDLYALVTELCVLDIFQPQDYVRSLISSGVLYISRLSEWANVQLDILGNLPLVAVPSSCQVQVRYMVRKVAKYASYNENELLERTNNALRVLLPGVFDSQAEDVDMSSSSSSLSDSTNIPYSEFTQNTRIVVAENLYTSLCAAVERGYVPTTQEFAQYQLILENLHAWRLMCASIQLIVPKCTQSHLLYFLASATRYQWQAFACIADMPALVKVFMHQYRGLRKVRVSRELWDLVQFSAQQLPELKPELETLLKNSSSPQLSPISEVTPQTDSEATKDVNLPQALNDLLLHSSDVRTSCKMLANYKDDSQFSNQLMTWLRDQEVSLQLLQTLVFLVVYECTCIEKVGDLFLQIHNLRDMSGGSRLLLSLIARDLTQEYSLSTTEAFSLQFQRKLFADQHPRIYLRLVAQYLFEREVFQDPQWLDDVDTFCKEVAVHHPALFSQLIVDPVIEPDNAVAASSLQQLLNHLLKLDLGTGTSLADDLQQLITHVTPFNMFLAQTQLRLLFAHRGRISKDPVAMDTSPELTINSTTPSTDTTDEDVSVLFRVLSDPGLLKLPPFFGDLFSELPGELKGRILARAETTFLTSPNFPRVGEDNIVSLLIELADSLADSVTEDVCKTQTFALSSGLQRLVEASVREPHPPGLAEGISMFLKIAMIHEKSLMASEDAEVTMLRNHVVEGLQALLDSPFVATTPDLKATLQDTWTALKSELSEVAEPANSAPSKAGPTRDLLLYSTANDAFSEVTVRSFDLLEESNPTMGVNDAALNLALFNATIEKRIPIAWNNGHKRQLVDGGRGGRKTARGTDSSLVPTILEGIPRCMDEYSNHWELFFCFYLYTMRASEVHDLRANRASSFERRASSVELLA
Length1362
PositionKinase
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Dipodascaceae> Yarrowia.
Aromaticity0.07
Grand average of hydropathy-0.133
Instability index45.18
Isoelectric point5.74
Molecular weight151976.75
Publications
PubMed=15229592

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32601
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.35|      28|      29|     636|     664|       1
---------------------------------------------------------------------------
  636-  664 (47.10/32.84)	LCAAVERgYVP.TTQEFAQYQLILENLHAW
  667-  695 (45.25/26.58)	MCASIQL.IVPkCTQSHLLYFLASATRYQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.45|      42|     461|     743|     788|       2
---------------------------------------------------------------------------
  743-  788 (65.16/45.49)	PELETLLKNSSSPQLSPISEVTPQTDSEATKdvnlPQALNDLLLHS
 1190- 1231 (71.30/41.12)	PDLKATLQDTWTALKSELSEVAEPANSAPSK....AGPTRDLLLYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.36|      23|      39|     939|     963|       4
---------------------------------------------------------------------------
  939-  963 (30.24/27.41)	QLIVDpViEPDNA.VAASSLQQLLNH
  981- 1004 (37.11/22.44)	QLITH.V.TPFNMfLAQTQLRLLFAH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.75|      18|     843|      12|      31|       9
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   12-   31 (23.93/23.46)	SRLYRSINSRdDLSQQrYVL
  859-  876 (30.81/18.55)	SRLLLSLIAR.DLTQE.YSL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.13|      13|      35|    1007|    1019|      10
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 1007- 1019 (23.19/14.76)	RISKDPVAMDTSP
 1042- 1054 (22.95/14.51)	RVLSDPGLLKLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.17|      16|      38|    1078|    1093|      13
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 1078- 1093 (29.03/17.97)	TFLTSPNFPRVGEDNI
 1117- 1132 (25.14/14.54)	TFALSSGLQRLVEASV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     295.90|      96|     237|     286|     387|      18
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  286-  387 (141.93/111.30)	SKLSsvEKLPVAILIIRTFwkPLLTFPNLAKKLAQNLLAELSKLEadAHSDKPFYQPTIKALSTLVNALFDAQPDAFVMPSKWVQLGSTFEAIVSD.SESTRV
  530-  626 (153.96/101.09)	SRLS..EWANVQLDILGNL..PLVAVPSSCQVQVRYMVRKVAKYA..SYNENELLERTNNALRVLLPGVFDSQAEDVDMSSSSSSLSDSTNIPYSEfTQNTRI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32601 with Med12 domain of Kingdom Fungi
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