<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32599

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSNRDSANPPGFNDAVPLAICYIDSSTSSHDEYLTLLQSKVSAPDKNFRDETVDGAPFLAGDAISKGHRYSPPVRSDRASAQGLLQQHLEKSSTLENLKRYSSTLLGRQNDAVIDEPFAPFRPPPRVTLSESRRDRWLQGLSDPMVPLSSLIKTIPHGLWGEDILRMLVKFRVPFTRAIWFIRCAGVNEARSFLRKVQTTDITEWVKNWTDVAAGFLISFISSFLNADIYSFADDYTYLLKLFGRLLAEELVSPKHFLLRIVSFSGDSSLKSFSLHFFALQFFSTSLIQYTHICRKCVITILQSYQQLIVDQPANLLKFSLLSKKVSHFLFTLAQKNIESFFFPTEWDKLKPTIILLWKDFPNYSTLLSIMQERNSKAMYMYKPVTSSIRFLQIISCLSFPVGWRTLAKDLFKLLPVYTGVPLLLHWCINCRSIFSGDRNFIVSSIFDNANFDRNLIVDLTLSFVLKLHPLEYNECVAAAQLLDHLAACGYFFFSKYIARLASLGYLRESMLNSSFMDDQRKILVQLPILRMSQQLKNKIYYILSKGNYFVDWSICDEYVKRFKEDHFSFMFKKEENYAIITLSLVKIASTPMSKLYEDYLVMLFAFHYSMFQVMTKLIADNLVHFSFQSCACQTLFFICSVVPKTESQKLLLNEMGKLFQVELNFSYDSPDVNLLIEQFYEITSYESNYDDAFVEYKDATVANRKDFIEFLFHNITVSSKHTAVIFTSDLLMVLKIALNHPPYFDDLATTTFSSLLKRDECTILSFFKILQFYGCKLLSVDQIWAVVSDVYEAQDNNTTLKQFFNYLLDESTWPEGYLEERHWRSILCKEARKHDSGLKLFKLGIKLCTRNEQIMKTIWSFIHVHDCNVISEVIPDQRFLRTLTEHFMIDLRQLDIVTCLKKALVTLDEFSAPLYATWLTTLDDDELSELTDDVVQKKVLESLDNYKSGIWKLVLSGLPNCKTVFEHLLLFSLEERLDLPAAFLQDLIGASAYVMEQVPDSWFLEKLPCPLTQSLQSFSHLSNHIEVLDSTRQSRLTFLCHLILHMHGFVELTDQLATLESLTIRKCIYRNQELLDLLLFSIHLVKPNVETNDEVCNTLKAWENIESRPYTIDFPEALQQYSPRIVLYEPTFW
Length1134
PositionKinase
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.13
Grand average of hydropathy0.012
Instability index42.96
Isoelectric point6.02
Molecular weight131244.01
Publications
PubMed=11859360
PubMed=12738880
PubMed=14534314

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IPI:PomBase
P:positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IPomBase

GO - Biological Function
transcription coactivator activity	GO:0003713	ISO:PomBase

GO - Biological Process
negative regulation of cell-cell adhesion	GO:0022408	IMPomBase
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IC:PomBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32599
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.18|      31|      38|     880|     916|       1
---------------------------------------------------------------------------
  880-  915 (40.66/30.67)	FLRTLTEHfmiDLRQL..DIVTclKKALVTLDEFSAPL
  919-  951 (48.52/23.30)	WLTTLDDD...ELSELtdDVVQ..KKVLESLDNYKSGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.78|      30|      38|     581|     618|       2
---------------------------------------------------------------------------
  568-  597 (48.05/27.59)	FSFMFKKEENYA.IITLSLVKIA..STPMSKLY
  605-  637 (42.74/28.67)	FAFHYSMFQVMTkLIADNLVHFSfqSCACQTLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.00|      13|      38|     231|     243|       3
---------------------------------------------------------------------------
  231-  243 (23.61/11.27)	SFADD...YTYLLKLF
  263-  278 (19.39/ 8.03)	SFSGDsslKSFSLHFF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.00|      26|      30|    1001|    1030|       4
---------------------------------------------------------------------------
 1001- 1030 (39.70/42.19)	DSwfleKLP..CPLTQSLQSFSHLSNHIEVLD
 1034- 1061 (40.30/28.71)	QS....RLTflCHLILHMHGFVELTDQLATLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.05|      29|      31|     377|     405|       5
---------------------------------------------------------------------------
  377-  405 (54.95/29.72)	KAMYMYKPVTSSIRFL..QIISCLSFPVGWR
  409-  439 (45.10/23.19)	KDLFKLLPVYTGVPLLlhWCINCRSIFSGDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.70|      29|     106|     659|     697|       6
---------------------------------------------------------------------------
  668-  696 (50.94/44.20)	YDSPDVNLLIEQFYEITSYESNYDDAFVE
  792-  820 (52.76/22.65)	YEAQDNNTTLKQFFNYLLDESTWPEGYLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.70|      15|      30|     180|     194|      10
---------------------------------------------------------------------------
  180-  194 (29.26/21.56)	WFIRCAG..VNEARSFL
  209-  225 (22.45/14.67)	WTDVAAGflISFISSFL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32599 with Med12 domain of Kingdom Fungi
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