<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32598

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSKARSRNSLLSSSNRAQFGNSTQDELLKLKFSMEKPDIGLYPLNDLDNGVDLNGDNSRSQHTAGSGVLSGNEVTYPDYKPWKDHTALPNDKKEQEHQKLNNAAYLNKGYFETPVVANEYYSARNLIQATVFSSTENCNEVLKELSQHLANAYKTRNEIINKIKYESNNFKIPPRVTLTASKKESWLKDLANPDLALSKIAEKIPHGIRNKILIDAVCNKSVPINRALWFTKCVLFGELVALRRKHQSRMSLNSPIPQSLDINTPEKFEIHWLQEWTQQVADYIYKFSKESSNFNTIERKQYYMNKMTYLLTYIQALYVEFLLDKSFFLALIIKFLKEGLPLDPLHVSELLSSTRSETDDLIQESWIEDLDLNYGQRLFALTLIKIFWNDILKFDYICKELSETLLLNYLFISKINAYSFKQSHVQNHKASIPEPLRQKILDMIGDTITYLFKFNTNVFIIPNYWMLINGVLFTILLNKNVTKTEGELDEISKQFDLIKYRNESLILNMRNVQPSITDRATPNSAGRRGSSIWNQSFVSAAESTATKIDIFDNEATFINRSSDDILKIISQLDSLKLNDELANFLKPVTSSSALTSTAIKGCPKWRTNLKVVLYWCITRHRNSRESSEDILIICNFLKRKVLQTLGPTRSSSQLKAEFESEILDIIYNIADTNSSKVVNYDLYVLINELYQLKVLTIASYLRKLIASGIFYVAPDAEDNILNDNSNSLVKTHLSILQNLPVINNRQCDSILKKWTSTGFNFKEKFEMGQEILKRELIDRIVNNTFDDQFESHIVYVKDLNVGLKFLLVNWVTNELKSAITESPKLIHINPLIISNLFNFYSICDNLTVFFKVLVKFILKNEGGMIIFYLESLYLIARLIIKHFKLVKFIAGNSYGSNSTAYELFKLIIQNYKDCKTREFDYFKFDQVWNFIDTAVESNYSSDKNTDSRSSGKRSGIFNKEQFDSPMKINTSENVIAKMEDRYTSADFRNDLDLLLESTFQPMDSNEVSEVVATLKLEFEENEMKSHRNVVPKVLDLLKSNLTEESEGLAAKLLINSQYLIKSDDVNAFDKLVQDYILELVKSDMEILLVAKFLKKLIVHEIIRINDLFAFFEPIAEDPAFRVKLKALMFDLVIGLSDEEREYLSNSQILQLEIMRQWYRERSTSSFLVLILKGIKTIEGSIFDCPLMEKYGSSIFRILNALIVANTKLLSDELISKISTEDSIRLLSTLNNENFTPINSLQDLERIASEVDEFNLPIFQLLLRVLTIKELSPLQENEIQERLKVLLESFLENLSFGFTPMNSYFGELFIYLPWEYVVSILGMLEDKFLCSTTFNFDQWDNDKSVLSLTNSVGNTNLLPVFNDYFKKFSSSSSNVVESSSSFFQALSKFLSKLLLIVNSDNCLEDTFEDTSSAISIFLRILIIHKLTLTRLIVTQDGEQFQFIKNLILLINSKFIAEGNEKLRILLYDLLLLMKSSVTEEVSKQTENELSEGTSPGFGMTAQSPPPVEDASKITEPLSSARPSSEAASFQTNPISTYDQVSSLFNLPEPTETNPFKDYITEDRVECALTLSEDELQSGGDIHGFNESNLVLISSSNDSTFSGAFALITNPHQRPKGQPFKLRSFEILEGTSTTSLNDGCINLQLFDSYTTKENPP
Length1654
PositionKinase
OrganismScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Scheffersomyces.
Aromaticity0.10
Grand average of hydropathy-0.195
Instability index38.68
Isoelectric point5.33
Molecular weight189208.82
Publications
PubMed=17334359

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32598
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.37|      29|      30|     829|     857|       1
---------------------------------------------------------------------------
  829-  857 (51.96/32.83)	N..PL....IISNLFNF....YSICDNLTVFFKVLVKFI
  860-  889 (42.51/25.42)	NegGM....IIFYLESL....YLIARLIIKHFK.LVKFI
  892-  924 (28.90/14.75)	N..SYgsnsTAYELFKLiiqnYKDCK..TREFDYF.KF.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     251.11|      51|      60|    1188|    1239|       2
---------------------------------------------------------------------------
 1188- 1238 (77.95/46.89)	EKYGSSIFRIL...N.ALIVANTKLLSDELI...SKI........STEDSIRLLSTLNNEN..FTPIN
 1251- 1301 (63.89/34.40)	DEFNLPIFQLL......LRVLTIKELSPLQE...NEI........QERLKVLLESFLENLSfgFTPMN
 1303- 1359 (42.78/23.18)	..YFGELFIYL...PwEYVVSILGMLEDKFL...CSTtfnfdqwdNDKSVLSLTNSVGNTN..LLPV.
 1365- 1410 (36.45/15.33)	KKFSSSSSNVVessS.SFFQALSKFLSKLLLivnSDN........CLED......TFEDTS.......
 1414- 1442 (30.04/13.50)	.....SIF..L...R.ILIIHKLTLT.........................RLIVTQDGEQ..FQFI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.60|      52|      58|     973|    1024|       3
---------------------------------------------------------------------------
  973- 1024 (85.58/50.86)	NVIAKMEDRYTS..ADFRNDL..DLLLESTF..QPMDSNEVSEVVATLKLEFEENEMK
 1028- 1085 (69.02/39.56)	NVVPKVLDLLKSnlTEESEGLaaKLLINSQYliKSDDVNAFDKLVQDYILELVKSDME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     264.60|      89|     177|     183|     284|       4
---------------------------------------------------------------------------
  183-  284 (134.59/95.93)	KESWLKDLanpDLALSK..IAEKIPHGIRNKIL.IDAVCN...KSVPINRaLWFTKCVLFgelvALRRKH.QS.RMSLNSPIPQS.LDINTPekfEIHWLQEWTQQVadYI
  363-  460 (130.01/66.11)	QESWIEDL...DLNYGQrlFALTLIKIFWNDILkFDYICKelsETLLLNY.LFISKINAY....SFKQSHvQNhKASIPEPLRQKiLDMIGD...TITYLFKFNTNV..FI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.02|      48|     535|      15|      71|       5
---------------------------------------------------------------------------
   15-   71 (69.34/68.62)	NRAQFGNSTQDELLKLKFSMEKpdiglYPLND.LDNGvdLNGDNSRSQHTagSGVLSG
  553-  601 (74.68/47.91)	NEATFINRSSDDILKIISQLDS.....LKLNDeLANF..LKPVTSSSALT..STAIKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.53|      36|     433|    1103|    1139|       7
---------------------------------------------------------------------------
 1103- 1139 (55.90/34.46)	RINDLFAFFEPIAEDPaFRVKLKALMFDLVIGLSDEE
 1538- 1573 (61.64/34.35)	QVSSLFNLPEPTETNP.FKDYITEDRVECALTLSEDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32598 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SKQTENELSEGTSPGFGMTAQSPPPVEDASKITEPLSSARPSSEA
1481
1525










Molecular Recognition Features






MoRF SequenceStartStop




1) ELLKLKFSMEKPDIGLYPL
26
44