<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32598

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSKARSRNSLLSSSNRAQFGNSTQDELLKLKFSMEKPDIGLYPLNDLDNGVDLNGDNSRSQHTAGSGVLSGNEVTYPDYKPWKDHTALPNDKKEQEHQKLNNAAYLNKGYFETPVVANEYYSARNLIQATVFSSTENCNEVLKELSQHLANAYKTRNEIINKIKYESNNFKIPPRVTLTASKKESWLKDLANPDLALSKIAEKIPHGIRNKILIDAVCNKSVPINRALWFTKCVLFGELVALRRKHQSRMSLNSPIPQSLDINTPEKFEIHWLQEWTQQVADYIYKFSKESSNFNTIERKQYYMNKMTYLLTYIQALYVEFLLDKSFFLALIIKFLKEGLPLDPLHVSELLSSTRSETDDLIQESWIEDLDLNYGQRLFALTLIKIFWNDILKFDYICKELSETLLLNYLFISKINAYSFKQSHVQNHKASIPEPLRQKILDMIGDTITYLFKFNTNVFIIPNYWMLINGVLFTILLNKNVTKTEGELDEISKQFDLIKYRNESLILNMRNVQPSITDRATPNSAGRRGSSIWNQSFVSAAESTATKIDIFDNEATFINRSSDDILKIISQLDSLKLNDELANFLKPVTSSSALTSTAIKGCPKWRTNLKVVLYWCITRHRNSRESSEDILIICNFLKRKVLQTLGPTRSSSQLKAEFESEILDIIYNIADTNSSKVVNYDLYVLINELYQLKVLTIASYLRKLIASGIFYVAPDAEDNILNDNSNSLVKTHLSILQNLPVINNRQCDSILKKWTSTGFNFKEKFEMGQEILKRELIDRIVNNTFDDQFESHIVYVKDLNVGLKFLLVNWVTNELKSAITESPKLIHINPLIISNLFNFYSICDNLTVFFKVLVKFILKNEGGMIIFYLESLYLIARLIIKHFKLVKFIAGNSYGSNSTAYELFKLIIQNYKDCKTREFDYFKFDQVWNFIDTAVESNYSSDKNTDSRSSGKRSGIFNKEQFDSPMKINTSENVIAKMEDRYTSADFRNDLDLLLESTFQPMDSNEVSEVVATLKLEFEENEMKSHRNVVPKVLDLLKSNLTEESEGLAAKLLINSQYLIKSDDVNAFDKLVQDYILELVKSDMEILLVAKFLKKLIVHEIIRINDLFAFFEPIAEDPAFRVKLKALMFDLVIGLSDEEREYLSNSQILQLEIMRQWYRERSTSSFLVLILKGIKTIEGSIFDCPLMEKYGSSIFRILNALIVANTKLLSDELISKISTEDSIRLLSTLNNENFTPINSLQDLERIASEVDEFNLPIFQLLLRVLTIKELSPLQENEIQERLKVLLESFLENLSFGFTPMNSYFGELFIYLPWEYVVSILGMLEDKFLCSTTFNFDQWDNDKSVLSLTNSVGNTNLLPVFNDYFKKFSSSSSNVVESSSSFFQALSKFLSKLLLIVNSDNCLEDTFEDTSSAISIFLRILIIHKLTLTRLIVTQDGEQFQFIKNLILLINSKFIAEGNEKLRILLYDLLLLMKSSVTEEVSKQTENELSEGTSPGFGMTAQSPPPVEDASKITEPLSSARPSSEAASFQTNPISTYDQVSSLFNLPEPTETNPFKDYITEDRVECALTLSEDELQSGGDIHGFNESNLVLISSSNDSTFSGAFALITNPHQRPKGQPFKLRSFEILEGTSTTSLNDGCINLQLFDSYTTKENPP
Length1654
PositionKinase
OrganismScheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Scheffersomyces.
Aromaticity0.10
Grand average of hydropathy-0.195
Instability index38.68
Isoelectric point5.33
Molecular weight189208.82
Publications
PubMed=17334359

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32598
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.37|      29|      30|     829|     857|       1
---------------------------------------------------------------------------
  829-  857 (51.96/32.83)	N..PL....IISNLFNF....YSICDNLTVFFKVLVKFI
  860-  889 (42.51/25.42)	NegGM....IIFYLESL....YLIARLIIKHFK.LVKFI
  892-  924 (28.90/14.75)	N..SYgsnsTAYELFKLiiqnYKDCK..TREFDYF.KF.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     251.11|      51|      60|    1188|    1239|       2
---------------------------------------------------------------------------
 1188- 1238 (77.95/46.89)	EKYGSSIFRIL...N.ALIVANTKLLSDELI...SKI........STEDSIRLLSTLNNEN..FTPIN
 1251- 1301 (63.89/34.40)	DEFNLPIFQLL......LRVLTIKELSPLQE...NEI........QERLKVLLESFLENLSfgFTPMN
 1303- 1359 (42.78/23.18)	..YFGELFIYL...PwEYVVSILGMLEDKFL...CSTtfnfdqwdNDKSVLSLTNSVGNTN..LLPV.
 1365- 1410 (36.45/15.33)	KKFSSSSSNVVessS.SFFQALSKFLSKLLLivnSDN........CLED......TFEDTS.......
 1414- 1442 (30.04/13.50)	.....SIF..L...R.ILIIHKLTLT.........................RLIVTQDGEQ..FQFI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.60|      52|      58|     973|    1024|       3
---------------------------------------------------------------------------
  973- 1024 (85.58/50.86)	NVIAKMEDRYTS..ADFRNDL..DLLLESTF..QPMDSNEVSEVVATLKLEFEENEMK
 1028- 1085 (69.02/39.56)	NVVPKVLDLLKSnlTEESEGLaaKLLINSQYliKSDDVNAFDKLVQDYILELVKSDME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     264.60|      89|     177|     183|     284|       4
---------------------------------------------------------------------------
  183-  284 (134.59/95.93)	KESWLKDLanpDLALSK..IAEKIPHGIRNKIL.IDAVCN...KSVPINRaLWFTKCVLFgelvALRRKH.QS.RMSLNSPIPQS.LDINTPekfEIHWLQEWTQQVadYI
  363-  460 (130.01/66.11)	QESWIEDL...DLNYGQrlFALTLIKIFWNDILkFDYICKelsETLLLNY.LFISKINAY....SFKQSHvQNhKASIPEPLRQKiLDMIGD...TITYLFKFNTNV..FI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.02|      48|     535|      15|      71|       5
---------------------------------------------------------------------------
   15-   71 (69.34/68.62)	NRAQFGNSTQDELLKLKFSMEKpdiglYPLND.LDNGvdLNGDNSRSQHTagSGVLSG
  553-  601 (74.68/47.91)	NEATFINRSSDDILKIISQLDS.....LKLNDeLANF..LKPVTSSSALT..STAIKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.53|      36|     433|    1103|    1139|       7
---------------------------------------------------------------------------
 1103- 1139 (55.90/34.46)	RINDLFAFFEPIAEDPaFRVKLKALMFDLVIGLSDEE
 1538- 1573 (61.64/34.35)	QVSSLFNLPEPTETNP.FKDYITEDRVECALTLSEDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32598 with Med12 domain of Kingdom Fungi
Unable to open file!