<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32597

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRPALGTHGSGAPSRNQVRRPSKPANALPPDCIDPTLEDERPAAHNGASEARPPPRGRPHIFYSTLASSAFDLPIHSFPYQPTVNLPVPPRPGSLHLRDASQQRQILPGGTGVKDAPKLGVPETVPIPVHFPGEKAADVFPWTGTNAEDTLSEALVKAGVSNKPQIMNETNTARPSLWSNLKNKSGITTLSTLFVAVLEKRQQNGRLQTPNTFKPPPRLTLRDSTREGWLHDLANPTVSLRRLSRTIPHGLTGKVLLDQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFLDSVISTIGQGDWKLRITYALQLATHLYKEHLLDDDHFLGWIPFGLDMCSSERLFIWLLVVAVPHYWNDISSCRQRGKRLAESLLNHLAKLSPIEDLAAPSTALQFLENSLLKLVTTRPACLLLPISWPKHSAALKALVTKRNLPQTAQAVEKLDGRNTRLLSFVRNGKSSSRTGAARVFHKLDSINYAAPIRIEDLSYECMEITSNAVQLISTLLHWACSCYRAGSHRIYLATRLLRRWSHLGADVYEGIIVYLQSMSWVKSGEIHVLLRIVAELVRSKHFSVGRYLQWLIATGSLGCDASLSLPSSWPVRLITEVPLTGLSDQVRTLRSTLLRGTAHSTELEEQALVNVKQSISQAVPAIFGLSLTIPSRIELNFAKLSGTIRLEIGIWLRQQVAQHAEVNEQSYLEQCEDLAILADVIGITASSLDMAVLASVADTLLYHMKTFRAIGAFDPLLGRLAMRYAAIRTVKFPERELLLSFQNLARTAQPDGQLLQLLAYDLSRLDQKNAVAACSPASDNMGEVMQHAGTCSDDEIERILSSGTSMDQNMMSRVLRKLVRNLEEHVDKGYRQFENHPAWFWRLRNFDEATFDVVLREWLETSIMACQLHILQIAIPPLVASSCMELSSFLDILRSCLANAKATQVLEPATIAIDLLRLLLPSGLSAMSCSSQDAYRYRTEQYKLCFTSDTRIIHCIGEVADLVLSTPSNSMLQTVSSLLSSETVLSIVKEHVVSDPDCLSKMKTGQSGQASFNTCFKTLLNGLLDPSGQWCLADISPEEQIIAVFKAASELSLPLCQAMIEHIFASSSALDTHAVDRLSVTVLNAVRTSMEKDQSQGLELLTNLEGPLADKIRSHAEREVLDASYFLLRGSTDGIASDCIVTAKMMQKYLTVIELTMGETPQADEQFAMLAALTDRFKGIFHALSECGGLGTPTNQATASPVVQVLAALLSLVASHGPQLLRNATQSHQAALMVALQDIVTHASLELFPSIIEHVFDVLIVLSDHISEDVRNQIARLESAKSTNSDRAYFIHSQKAPIDGWLMLTKPVIPPLEPPQPPNPNTTQNQSSPYQSPQMTSNTAAPQHRYFNQQQQQSQTLQPSQQTQHMRTYPQYAQHAAQPNRHLPAQLQRTPSHHASLSPLQQMQHMQQLQGLAQQRASQPSPIHSQRPTSVASPGGMGGLAGGNAAPSKAHTSYVNQQRDTQQYPFVQPRWEILAESSGNPTLNETAISLSLFGARRV
Length1547
PositionKinase
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Phaeosphaeriaceae> Parastagonospora.
Aromaticity0.06
Grand average of hydropathy-0.172
Instability index51.07
Isoelectric point8.26
Molecular weight170652.26
Publications
PubMed=18024570

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32597
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.18|      12|      15|     249|     262|       1
---------------------------------------------------------------------------
  249-  262 (17.28/14.88)	IPhgLTGKVLLDQC
  267-  278 (23.90/12.47)	IP..LPRALWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     405.13|     139|     160|     808|     965|       2
---------------------------------------------------------------------------
  806-  963 (208.76/210.62)	LLAYDL.SRLdqknAVAACSpASDNMGEVMQHAGTC..SDDEI........ERILSS.GTSMDQNMMSRVLRKLVRNL.EEHVdkgyrqfENHPAWFWRLR.......NFDeATFDVVLREWLETSIMACQLHI...LQIaIPPLVASSCMELSSFLDILRSCLANAKATQvlepaTIAID
  964- 1125 (196.37/146.86)	LLRLLLpSGL....SAMSCS.SQDAYRYRTEQYKLCftSDTRIihcigevaDLVLSTpSNSMLQTVSSLLSSETVLSIvKEHV.......VSDPDCLSKMKtgqsgqaSFN.TCFKTLLNGLLDPSGQWCLADIspeEQI.IAVFKAASELSLPLCQAMIEHIFASSSALD.....THAVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     148.84|      36|      38|    1391|    1428|       3
---------------------------------------------------------------------------
 1364- 1387 (37.67/15.57)	..........PQPPNPNTTQNQSSPYQSPQMT..........SN
 1388- 1424 (66.18/33.82)	TA.......aPQHRYFNQQQQQSQTLQPSQQTQHMRTYPQYAQH
 1425- 1464 (44.99/24.33)	AAqpnrhlpaQLQR....TPSHHASLSPLQQMQHMQQLQGLAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.43|      27|     161|      54|      88|       4
---------------------------------------------------------------------------
   54-   88 (40.73/48.50)	RPPPRgrphifySTLASSAFDLPIHSFPyQPTVNL
  216-  242 (51.70/33.28)	KPPPR.......LTLRDSTREGWLHDLA.NPTVSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.77|      24|     160|    1147|    1183|       5
---------------------------------------------------------------------------
 1147- 1170 (36.77/17.51)	LELLTN.LEGPLADKIRSHAER.EVL
 1305- 1329 (30.73/11.59)	FDVLIV.LSDHISEDVRNQIARlESA
 1350- 1361 ( 5.27/14.94)	WLMLTKpVIPPL..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.91|      11|      15|      94|     104|       9
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   94-  104 (20.12/ 8.94)	PGSLHLRDASQ
  110-  120 (20.78/ 9.45)	PGGTGVKDAPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.62|      14|      16|     773|     787|      10
---------------------------------------------------------------------------
  773-  787 (19.02/13.33)	YAAI.RTVKfPERELL
  790-  804 (20.59/ 9.32)	FQNLaRTAQ.PDGQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.90|      62|    1338|     128|     192|      11
---------------------------------------------------------------------------
  128-  192 (98.58/56.26)	PIPVHfpGEKAADVFPWTGTNAEDTLSEALVKAGVS..NKPQIMNETNTARPSlWSNLKNKSGITTL
 1469- 1532 (107.32/52.43)	PSPIH..SQRPTSVASPGGMGGLAGGNAAPSKAHTSyvNQQRDTQQYPFVQPR.WEILAESSGNPTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.83|      12|     316|     351|     363|      12
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  351-  362 (23.27/19.40)	IPFGLDMCSSER
  372-  383 (25.55/15.12)	VPHYWNDISSCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.52|      26|      26|    1245|    1270|      15
---------------------------------------------------------------------------
 1245- 1270 (40.63/25.77)	QATASPVVQVLAALLSLVASHGPQLL
 1272- 1297 (41.90/26.82)	NATQSHQAALMVALQDIVTHASLELF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.84|      28|      46|     617|     646|      17
---------------------------------------------------------------------------
  617-  646 (38.59/39.78)	SWPVRLITEVPLTgLSDQVrTLRSTLLRGT
  665-  692 (46.25/34.76)	SQAVPAIFGLSLT.IPSRI.ELNFAKLSGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.84|      18|      19|     510|     527|      18
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  510-  527 (32.86/22.22)	CMEITSNAVQLISTLL.HW
  531-  549 (29.97/19.54)	CYRAGSHRIYLATRLLrRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      21.38|       8|      26|     389|     400|      19
---------------------------------------------------------------------------
  389-  400 ( 7.65/13.31)	LAESLLnhlaKL
  416-  423 (13.73/ 6.07)	LENSLL....KL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32597 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LTKPVIPPLEPPQPPNPNTTQNQSSPYQSPQMTSNTAAPQHRYFNQQQQQSQTLQPSQQTQHMRTYPQYAQHAAQPNRHLPAQLQRTPSHHASLSPLQQMQHMQQLQGLAQQRASQPSPIHSQRPTSVASPGGMGGLAGGNAAPSKAHTSYVNQQRDTQ
2) MTSRPALGTHGSGAPSRNQVRRPSKPANALPPDCIDPTLEDERPAAHNGASEARPPPRGRPHIFY
3) PYQPTVNLPVPPRPGSLHLRDASQQRQILPGGTGVKDAPKLGVPETVPIP
1353
1
81
1511
65
130










Molecular Recognition Features






MoRF SequenceStartStop




NANANA