<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32596
Description |
Mediator of RNA polymerase II transcription subunit 12 |
Sequence | MTSRPPLGVQQRQPQQRKLSGPVLSQQRSLSQSQAQAQAQAQQQQQQQQQQQQQQQQQQQQQQQQQYDASSYLPPPPPVPTRNNNHNNFSNPNNTLNNAFPPELAQQDPTSIVSPADPSGSSPALSVGVGRYGTQRRGGSRLRLELSHNDPFDAFSSPTVIESPGLVEPHTQNGSLTHPMMPLADGPDLGDMSPHHRVSIPPQHLDADVPIPFPQRRPKAVPDHSRREQPPPPPNPARKDTRPKPYTIELPAAAPRYRIRGRSDGQGGQGRSSALATASSSSTTGSSATANYGCADFFPWSGTAGNHPEDQFNDTAIRVGYSEKQFVTPETQSAKTVLFHGLKQRSGLNALSIFFAGVLWHRRNAGQVTAPSTFKPPPRVTLTDTKKEVWLKDLANSAIPLRKLSRSIPHGVRNKVLLDQCLNKNVPIDRAVWLAKCVGTNELRTFRRLGKGNNASVLEGERKWLKDWTLVIENFIERVFFSFGEQNWKAKVNYAIQLAAHLYAEGLMDREHYLDWTVSSLESSHHSQLPMWIIIAQIYWKDLLRLRKYGRRLATALISHYHVIHAHEDRDIYVPLLSKLSHLLGTLMVATPENFVSPSVWVKYRDALKTCLPQGDEARHRSFAGINYRNEQLVASANRSQPAARIILVRNLDQVILEKPMPDEFPAQCWTVSKDKAALVRALLEWCTTPYRPGLAKVYVAHRILMHWSTLRLDVTSAVLGFMEGEALEEMECKDALYHLVSELVRSGIFLVSQYIQWLITRGGLTDPQLVMPDGPPFSRLLAELPSHILGSSQKRSRDALLRRAGFRIADDAQDADMAIRHLRHALGLPAGVTDAVSMGRPFPIKKIARRIEDASRARKAEIASWLRNTVFGGELEHSSLNAFGQHDLSTRLFNSIRTVFEAAQEFSVFADVLRMLTKCSNPEVLASIADTITRYTFVFAALSCLKNLFSILHSRLREVQEQGIGARPLLASLAYLASRVPGMDEVAMQLKSDLAVSDRHNPVDACSPVSDNMVSRLSDHDGDLHEEVEKLLANGTSLDRNTMDRLFSAVIQRLQAYWSKGDEQQRVYGILLKRLRMFNPQHFDELMTRWLLYVRGLDTRATILHLYPLLVSIGCLEMPAILATASESPNALGAGNSRHPQSAVATSQIVQTTFRTRYMQEVLQLFMAPVSSESLLTPEERYRFGILQEQAKKESPRELLCLIQLALAEYTCARAQNDLEELPLDKEANQDRLLRLLKLLVLKDPVGVAKALQIRGPDAQIDGWIDRMTTKLLVTAAGEGTRVTFEQVLNLTNEFTLPFCHVKLLLSLSSNDQQQNAADSGERVPSNVELFMNAMEKSMDAQRVSWIGMLPSLSPDLTHHLKNQAQARFLNLLPSARNPPSMTLDRSMLQMRLQKAENFLAIMDTIIRGSGPMGFRQHQLVPVMVERFTDILELLQTLTPFPSQAGGLGGWGGQGASAAAAGGDSHIDLKSDILNHWLPLFLNFLTLHAQTFDTSKPGNEVRGRALMVCAGLIRELDLIHGPDFDTRQLGGRIFDLACVLVDNLAEDARLQCIQALKSPSDVKLRYIFSYQDNPHANLMLCHKERPTAMAIGTATGTGSPAPGTTPTHTPGVTPGPQNAVGAGSAVSGAGGSGNGGSYFSLPGHTQQAQAQGWHAAQQQQQQQQQQQSQQQQQQQQQQQYQLQQQQQQGGTGPIPSPAISINTNLTHLNLGNNSNPPTPSPMNPTRPAMMMVANPWGGYSWVPTMGGPQERLTPFNFRQWEMLSEPTSQVGENDTAVNLMLFESRKVQ |
Length | 1789 |
Position | Kinase |
Organism | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.398 |
Instability index | 51.18 |
Isoelectric point | 8.83 |
Molecular weight | 198737.51 |
Publications | PubMed=12655011
PubMed=12712197
|
Function
Annotated function |
Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP32596
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 141.08| 15| 15| 36| 50| 1
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34- 49 (27.45/10.70) QaQAQAQAQQQQQQQQ
50- 65 (29.97/12.32) QqQQQQQQQQQQQQQQ
1647- 1661 (27.89/10.98) Q.QAQAQGWHAAQQQQ
1662- 1676 (32.58/14.00) Q.QQQQQQSQQQQQQQ
1677- 1689 (23.18/ 7.96) Q.QQQYQLQQQQQQ..
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.25| 16| 18| 337| 354| 2
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337- 354 (23.69/17.43) VLFHglKQRSG.LNALSIF
358- 374 (26.56/13.08) VLWH..RRNAGqVTAPSTF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.80| 12| 15| 408| 421| 3
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408- 421 (16.66/14.99) IPhgVRNKVLLDQC
426- 437 (23.13/12.43) VP..IDRAVWLAKC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.35| 11| 15| 5| 16| 4
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5- 16 (18.56/14.11) PPLGvQQRQPQQ
22- 32 (19.79/ 9.74) PVLS.QQRSLSQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 90.62| 21| 21| 202| 222| 5
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202- 222 (37.30/17.08) PQHLDADVPIPFPQRRPKAVP
224- 242 (32.29/13.73) ..HSRREQPPPPPNPARKDTR
243- 258 (21.03/ 6.18) PKPYTIELPAAAPRYR.....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 63.87| 11| 16| 1716| 1726| 6
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100- 110 (18.05/ 6.02) FPPELAQQDPT
1716- 1726 (24.22/11.13) NPPTPSPMNPT
1735- 1745 (21.60/ 8.96) NPWGGYSWVPT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.88| 15| 15| 1587| 1601| 7
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1587- 1601 (27.23/13.68) PTAMAIGTATGTGSP
1603- 1617 (27.65/14.01) PGTTPTHTPGVTPGP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.60| 18| 21| 669| 688| 8
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671- 688 (31.39/24.21) TVSKDKAALV....RALLEWCT
689- 710 (29.21/12.70) TPYRPGLAKVyvahRILMHWST
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.75| 20| 20| 1045| 1064| 9
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1045- 1064 (34.14/16.50) DRLFSAVIQRLQAYWSKG.DE
1066- 1086 (30.60/14.13) QRVYGILLKRLRMFNPQHfDE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.83| 15| 17| 768| 782| 11
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768- 782 (28.81/18.06) PQLVMPDGPPFSR..LL
786- 802 (21.02/10.73) PSHILGSSQKRSRdaLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 68.33| 20| 22| 980| 1001| 12
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980- 999 (32.83/25.55) RVPGMDEVAMQLKSDLAVSD
1003- 1022 (35.50/19.67) PVDACSPVSDNMVSRLSDHD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.73| 19| 21| 1159| 1179| 13
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1159- 1177 (31.80/22.48) YMQEVLQLFMAPVSSESLL
1183- 1201 (31.93/14.92) YRFGILQEQAKKESPRELL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.58| 16| 21| 1499| 1519| 15
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1499- 1517 (21.58/21.89) GNEVRGRALmvcAGLIREL
1522- 1537 (30.00/12.53) GPDFDTRQL...GGRIFDL
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