<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32595

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQSWGQPLHAVYSGTGRADLSQPLGQPDRQPEQPSMPVPQLQGRPPALIDLTTNDGDVLEREPPAKRLKIDVHAGSVAGDGSPASAGVGESKSTPSATTSKPPSLSWRARPVWSFQALLSEVSGSAEINGESAAGVVQDVKPPPPPSFPGPPWKFAPADTIASDSAGAQDGAPSKEVQTTPYHIETPSVAPVIRGEKVADFSPWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQILSSVFAAALEKRQGHNMVTAPSTFKPPPRVTLTDNKREAWLRDLANPNVPLRKLSRTIPHGIRGRVLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALAIGLEAKWVRDWTANVQQFLEGVITSCGVADWKMKMTYAVSLTARLFFEQLLDHDQYLGWFLTSLEAAPFNTLPVWLLMLGIYWSNILRYRKRGRRLAELLLDKLQVAIKSDSATSLRPLTDRLSLHIRKLTLEHTSSMVLPQSWEKYKDLLSSCLDLNDNVHRAVFQNLAERNARVQRPRKCEETTQQPPQQRVIQLFDSIGSSNDITSVSAASLGAIDDKAALVLKLLEWAATPFRYGVSRVYTGARLLRKWKIAGVDVDTSIISFLGESQMRDQLNMDNIYHIVSELVRSQTFSVGKYLQWLMAKGVADFPQNSDHQPLSGDLALLMQLPVSRLPEHVHNLRNTLLHRAGVEVSKESSTIAILKASIAERLPRIFGSVATSAVSRDPLPSDLTWAVKSELGQWIRRGVTEFGRDPRRAFQDLHSAPSAEHFALTPGEFYTVRDILESFGDLSILADVLKQATVCNDGIVLASAADTVNYHFRSFCVIGATTDLFKRLVESYARLKRLGSTSLDLIFSLIDLGLRLPGELNTVALLRQDLSRIESKSSMAAPSPLSDHIPSSFNETDPLFLLKLDQLLSSASGIDESTLDTIFNLLIKQIESSGGHAKLSVNETCRYLSYLRPFHPKRFDIMIVRWICGLLRSTTGGILSQVLPPLIGVGCVTIQAFVFLVRRLLKSENMMSNQRDLRIDLLQLLVPPPAGQSRYFDMVTYRFHLSRKEFLFKHPEEVFDIIRDAIALIDSQSQEGNYRQVDLGHSAMVLLQILLTKNPESAVKHCTEKLIGQHPSAVTVLTRALDSLLGLDTKAGERLFTSNGSFIFITIDTGPAAPDISVAEKVIELTNDFSLPFCRLKLQLLFNAETKGDVRNEIVDVMFKAAVADSRSRRSNWVGLVRLMSHDAVRQIRERAEKNFFAIPLFEESPDGCSSFAADNSSSLETAKLYLAIIEKLAYSIPDVGPQAVVPVLTEKMDLLLQRLITMQANYSGTTELSHGVDAEHMIRSRTQFERALAFWFSALLRMIVLHRTAFSVPSAAVRPSALPEQTRLLISIFCITLARLPDSVLRLFPAADYFPHSMTAGDCRPCPGILLQTHALDVAASLIDTFPDEARHQCARYLREKCPPFARVQNDSRFLYLLGPLGDSPSSNITLPVSIPSPAASGSTPAPTPSGNPTGGFSHPQQPAFVSGVPTGLPDGLNCAASHLCLQYRGRAIGAYPVRPWELLEDAAPIAGTNDTAVSLGYFDARRVRV
Length1612
PositionKinase
OrganismNeosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.126
Instability index46.13
Isoelectric point8.53
Molecular weight177650.35
Publications
PubMed=18404212

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.82|      36|      96|     466|     501|       1
---------------------------------------------------------------------------
  466-  501 (58.33/34.93)	LLDKLQVA..IKSDSATSLRPLTDRLSLHIRKLTLEHT
  563-  600 (52.49/30.70)	LFDSIGSSndITSVSAASLGAIDDKAALVLKLLEWAAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.64|      20|      96|      28|      54|       2
---------------------------------------------------------------------------
   34-   53 (38.47/21.21)	QPDRQPEQPSMPVPQLQGRP
  146-  165 (41.17/14.32)	QDVKPPPPPSFPGPPWKFAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.06|      72|     188|     610|     743|       3
---------------------------------------------------------------------------
  338-  411 (115.29/61.96)	VGRAV.WL.AKCVgANEIRAFKRKGTSGALAIGLEAKwVRDWTANVQQFLEGVITSCGVADWKMKMTYAV...SLTARL
  663-  739 (108.76/40.60)	VGKYLqWLmAKGV.ADFPQNSDHQPLSGDLALLMQLP.VSRLPEHVHNLRNTLLHRAGVEVSKESSTIAIlkaSIAERL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.09|      37|      88|     773|     809|       4
---------------------------------------------------------------------------
  773-  809 (66.87/47.71)	RRGVTEFGRDPRRAFQDLHSAPSAEHFALT.PGEFYTV
  863-  900 (56.22/38.68)	KRLVESYARLKRLGSTSLDLIFSLIDLGLRlPGELNTV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32595 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSAEINGESAAGVVQDVKPPPPPSFPGPPWKFAPADTIASDSAGAQDGAPSKEVQTTPYHIETPSV
2) MIPHSSAGVQSWGQPLHAVYSGTGRADLSQPLGQPDRQPEQPSMPVPQLQGRPPALIDLTTNDGDVLEREPPAKRLKIDVHAGSVAGDGSPASAGVGESKSTPSATTSKPPSLSW
3) PVSIPSPAASGSTPAPTPSGNPTGGFSHPQQPAF
4) PWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLY
132
1
1514
211
197
115
1547
249










Molecular Recognition Features






MoRF SequenceStartStop




NANANA