<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32594

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSPSKYLLTPPEELHPLTDSNPQIYPDFDPWIHTKEEDKILKEFVAKGYYTASRVNFETISARSALQGSLPKVSSLLGDELSKIIEIREQEINRISTLDIEDSTRFTKWSGQDFHLPNRVTLTDQKRNLWLQELSSSNTSLRKLTKSVPHGFRKRHILEQCYTQFVPIYRVIWLIKSCYAIEWKGMISKAKGETTHEELLSTLYKDWTDNMVLILEKLVFEVSKYYNDPGQLKYWKLRIAHYLKILGNCYEMELLNRSTLHQWLVDFLSKIESFEFYPMTLHILSIFWSGILGTTEEDTEIESSFLIIKLSEILLRKYHIISESKCMINDSKYIINDVQRNSKLKESVLLRLRQFISHIFHTQSLEAFIMPKQNWNIYKNYLYQILLQNVSDEETPKLKKKLKLISYRNESLRLGSLDVEPSRETSPFSTELTLDNVFSGNILNLKNVSPELLGVLDSGLSGSEWSLFIDQKITKMEQVIEIILWAINPSRKHRYDSCHLVAKILVLKINSQESFQEYSIEDVIWSLIFHFSKLSKLELQKIVWLPKLHQLLNVFIGYGIIKVPTYIRRLISSGVLYLPESENKNFHCKLLINLKISPIMKSQYNMVLKNVMEYAPHFYEKYNFDKLVSIFESLKPKLLSGDFERLEEYPGSIRIMCSEWYLSQICFNQGELQKVNNHKIIKTFQLFCINLGELHHFFGWAEYIVYHQLIDDLENLEVFTDILLYLDKAFLLLINDHILFMKTLLHSYMRDLRIKDKAAFELINFKSFWKFFVKNCANMIEMDSSLQNQIAEVFELERHRKDHFTKMPNETVSLYLEITGNKNTKFEEQNFPSVIQQNIKKVLHNPEDESNCRKLLLLCKASHASEYNKFLSIFVKRGDFTVHELLKLISLKLLSFEVIQKTSHFDLLCELVSQVSFNYGLNFENEKNAFVKRNFKQITLQLFSRPTFRDTLVRMLVEYGPNSNLSEKSAQVVSHILREEKNMSIIRDMLIYGMNIENEAIDNTIDLYRYLNFTNTWLFQILTEFNVKNSNAEDLSDFFSSIVGAIGYNSLLPKIFSNISDKKQVSTLLTVIERQFLARVLETEKSALVFLHIMMDTEIVLSRHLVNMSSLGMDSEVLELFKNTIATFAKMPNDTLKKYDENLNELLKIVIIHEKFILRHCFESIELRDHYMVDNFYTLFHNTGKDLKLKLLLYDLLTSLKSYILNETKDQALHSIKMPSVLNQLPKFAISSFLDSEGTEDEFLDKDEPSLIRLGICDKQAKTNSALKYFVFNKKSSQFDCIFKIEPFQYLVNYQEPLEGELNNTSLSLGLFDARLEKTNPS
Length1322
PositionKinase
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.11
Grand average of hydropathy-0.196
Instability index44.73
Isoelectric point6.53
Molecular weight154878.26
Publications
PubMed=15229592

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32594
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     728.34|     210|     235|     255|     484|       1
---------------------------------------------------------------------------
  235-  377 (184.06/101.34)	................................................................................................WKLRI..AHYLKILG..NCYEMEL..........LN......RSTLHQW....LVD..F.LSKIESFEFYPmTLHILSIFWSGILGTTE.EDTEIESSFLIIKLSEIL..LRKYHIISES...KCMIND..S.KYIINDVQRNSKLKESVLLR.LRQFISHIFHTQsleaFIMPKQNWN.....I
  378-  618 (261.37/167.94)	YKNYLYQILlqnVSDEETpkLKKKL......KLISYRneslrlGSLDVEPSR...ETSPFSTElTLDNVFSGNILNLKNVSPELLGVLDSgLSGseWSLFI..DQKITKME..QVIEIIL........waIN......PSRKHRYdschLVAkiL.VLKINSQESFQ.EYSIEDVIWSLIFHFSKlSKLELQKIVWLPKLHQLLnvFIGYGIIKVPtyiRRLISS..GvLYLPESENKNFHCK..LLIN.LK..ISPIMKSQ....YNMVLKNVMeyaphF
  619-  852 (282.91/149.05)	YEKYNFDKL...VSIFES..LKPKLlsgdfeRLEEYP......GSIRIMCSEwylSQICFNQG.ELQKVNNHKIIKTFQLFCINLGELHH.FFG..WAEYIvyHQLIDDLEnlEVFTDILlyldkaflllINdhilfmKTLLHSY....MRD..LrIKDKAAFEL....INFKS.FWKFFVKNCA.NMIEMDSS.LQNQIAEVF..ELERHRKDHF...TKMPNEtvS.LYLEITGNKNTKFEEQNFPSvIQQNIKKVLHN........PEDESN.....C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.77|      48|     117|    1144|    1195|       3
---------------------------------------------------------------------------
   79-  131 (70.25/40.96)	DELSKIIEIREQEINR..ISTLDIEDSTRFTKWSGQdFHlpNrvTLTDQKRNLWL
 1144- 1193 (77.52/61.21)	NELLKIVIIHEKFILRhcFESIELRDHYMVDNFYTL.FH..N..TGKDLKLKLLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32594 with Med12 domain of Kingdom Fungi
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